Medical Engineering = MEDINEERING
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22 Y.O. received complete 3D Printed Cranium Replacement last December. She's back to work.

22 Y.O. received complete 3D Printed Cranium Replacement last December. She's back to work. | Medical Engineering = MEDINEERING | Scoop.it

"Implants used to be made by hand in the operating theatre using a sort of cement which was far from ideal,’ Verweij said. “Using 3D printing we can make one to the exact size. This not only has great cosmetic advantages, but patients’ brain function often recovers better than using the old method.”

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Carlos Garcia Pando's curator insight, March 26, 2014 11:52 AM

The 23 hour operation was performed by neurologist Bon Verweij, surgeon Marvick Muradin, and their highly skilled team.

Carlos Garcia Pando's curator insight, March 31, 2014 5:02 AM

Watching the picture I took for granted that it was some stereolithography material out of an Additive Manufacturing machine. My fault for that.

Going deeper into the story I found no evidence of the use of Additive technology to manufacture the implant. Apparently it has gone through the everyday routine of:

*   CAT and computer 3D model 

*   Some design

*   Stereolithography for a 3D model

*   Using the model as a Master to produce a silicone rubber (or other materials) mould

*   Casting or injecting some liquid PMMA

So apparently this is not such a "FIRST IN THE WORLD"

 

Medical Engineering = MEDINEERING
INNOVATION from every field that can be applied to human health.
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The Search for Better Bone Replacement: 3-D Printed Bone SCAFFOLD with Just the Right Mix of Ingredients

The Search for Better Bone Replacement: 3-D Printed Bone SCAFFOLD with Just the Right Mix of Ingredients | Medical Engineering = MEDINEERING | Scoop.it
To make a good framework for filling in missing bone, mix at least 30 percent pulverized natural bone with some special man-made plastic and create the needed shape with a 3-D printer. That’s the recipe for success reported by researchers at The Johns Hopkins University in a paper published April 18 online in ACS Biomaterials Science & Engineering .
Carlos Garcia Pando's insight:
Now they need to improve the properties and the topology of the scafolds  to improve the mechanical behaviour of the products.
sintermedical can help in this
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Non-invasive measurement of Blood Glucose

Non-invasive measurement of Blood Glucose | Medical Engineering = MEDINEERING | Scoop.it
Researchers have developed a method of measuring blood glucose using far infrared light, which is both harmless and non-invasive.
Carlos Garcia Pando's insight:

As opposite to near infrared only weakly absorbed by glucose, but also by water, protein and hemoglobin, far infrared light with wavelengths of around 10 micron is strongly absorbed by glucose, making it possible, in theory, for patients to get more sensitive and accurate measurements.

However, the problem faced by researchers, is that far-infrared light penetrates only a few microns from the skin's surface, which makes the detection of blood glucose difficult.

Prof. Matsuura's team has thus developed a new measurement technique that consists of a small prism attached to the ends of flexible hollow-optical fibers to radiate far infrared light. By using this method, it is possible to irradiate the oral mucosa of inner lips that, unlike skin, have no thick horny layer.

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Ekso Bionics to Establish Headquarters in Freiburg, Germany

Ekso Bionics to Establish Headquarters in Freiburg, Germany | Medical Engineering = MEDINEERING | Scoop.it

"Establishing this Germany-based subsidiary will allow us to enhance our customer service with training, education, and field service support by being in closer proximity to our valued customers," said Hausherr. "The Freiburg headquarters will also position Ekso to build strategic partnerships in the area."

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Researchers develop electrical stimulation to kill antibiotic resistant infections

Researchers develop electrical stimulation to kill antibiotic resistant infections | Medical Engineering = MEDINEERING | Scoop.it
The researchers optimized the reaction and developed an “e-scaffold,” a sort of electronic Band-Aid made out of conductive carbon fabric. By running electrical current through the fabric, they produced a low and constant concentration of hydrogen peroxide to kill the bugs.
Carlos Garcia Pando's insight:

Will these e-Band-Aids be wi-fi enabled to tell the doctor the healing process is going well?

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An effective yet simple demonstration of how Next-generation genetic sequencing is useful; furthermore: cheap

An effective yet simple demonstration of how Next-generation genetic sequencing is useful; furthermore: cheap | Medical Engineering = MEDINEERING | Scoop.it
Mystery Boy Brandon Keesing was incorrectly diagnosed with a degenerative muscular disease until revolutionary genetic sequencing gave him life-changing news.

 

Originally thought that Keesing has a mitochondrial disease, doctors had been wrong all along. Revolutionary advances in genetic sequencing proved he did not have mitochondrial disease at all. "In recent years the capacity to read the genetic code of every single gene — all 20,000 of them in the human body — has reached a point where it is now efficient, accurate, cost-effective to be able to do this," he says.


The new technique is called "next generation sequencing" — and where previously it took weeks or months to analyse the code of a single gene, today laboratory computers can decode all 20,000 genes in one go.


Almost immediately Westmead Children's Hospital researchers could pinpoint which one of Brandon's genes had a mutation. Professor Christodoulou illustrates how the technique works on a chart. "So here in the unaffected individual we have an 'A'. Here in the affected individual we have a 'G'. And that's precisely where the mistake is," he says.


Doctors using next generation sequencing discovered in fact that Brandon had congenital myasthenia — a different genetic disease which also affects the muscles. But although incurable, it is not usually fatal and can be treated with medication.


"The name of the gene that we found the mistakes in is called COLQ, and it has a completely different role," Professor Christodoulou says. "It has nothing to do with mitochondrial energy production. "What it is involved in is co-ordinating the communication of nerve cells with the muscle, so that the muscle, when it receives an impulse from a nerve cell, it contracts and relaxes appropriately.


"So the problem with the COLQ mistakes is that this process couldn't be co-ordinated properly. And that's what actually led to his progressive problems."


Finding that one gene in 20,000 has transformed Brandon's life. A simple drug quickly restored some of his muscle strength. As quickly as he had deteriorated as a toddler, he suddenly began making huge strides.

"We noticed it straight away. By the end of that week he got up off that bed and he walked," she says, wiping away tears. "That was unreal. I'll never forget that day. I was so happy for him and ... I just knew from that he was going to grow, he was going to enjoy his life that much more than what he had before. And he has."


Professor Christodoulou says it was a very gratifying outcome for doctors.


Via Dr. Stefan Gruenwald
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Samuel Viana's curator insight, October 30, 2015 7:38 AM

Quem diria, com a redução de preço das novas tecnologias de sequenciação foi possível diagnosticar correctamente a doença desta rapaz ?

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AXO-SUIT

AXO-SUIT | Medical Engineering = MEDINEERING | Scoop.it

AXO-SUIT is a three year project stated on October 1st 2014 and is funded under the Ambient Assisted Living (AAL) Joint Programme, Call 6. The project brings together 3 universities and 5 companies active and experienced in R&D of assistive devices to specify the full-body personal mobility, reaching, and grasping requirements of elderly persons allowing them to continue managing their daily activities related to voluntary occupation (maintaining gardens or carrying groceries of more needy people), as well as participating in local social activities while preserving their health and providing motivation to remain active and independent.

 

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Paraplegic man walks with own legs again

Paraplegic man walks with own legs again | Medical Engineering = MEDINEERING | Scoop.it
American man, 26, completes 3.5-metre course thanks to computer system that reroutes signals from his brain to electrodes on his knees
Carlos Garcia Pando's insight:

Rather than having a precise control of each leg, the patient activates the system with a general concept of walking, Do told Radio 4’s Today programme on Thursday. “It’s not so much that he’s thinking ‘move the right leg and than move the left leg’,” he said. “What happens is that the computer system detects when the brain waves change from a state of not walking into a state of walking

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Nanoparticles Used to Breach Mucus Barrier in Lungs

Nanoparticles Used to Breach Mucus Barrier in Lungs | Medical Engineering = MEDINEERING | Scoop.it
Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases
Carlos Garcia Pando's insight:

Most of the existing drugs for cystic fibrosis (CF), chronic obstructive pulmonary disease, asthma and other life-threatening lung diseases help clear infections but do not solve the disease’s underlying problems. A couple of recently approved drugs designed to target the underlying cause of CF require daily treatment for the entire lifetime and can benefit only a subpopulation of patients with specific types of mutations.

Yet this study has demonstrated that delivering normal copies of CF-related genes or corrective genes via the mucus-penetrating DNA-loaded nanoparticles could mediate production of normal, “functional” proteins long term. This could eventually become an effective therapy for the lungs of patients, regardless of the mutation type.

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Jocelyn Stoller's curator insight, August 5, 2015 4:18 AM

Most of the existing drugs for cystic fibrosis (CF), chronic obstructive pulmonary disease, asthma and other life-threatening lung diseases help clear infections but do not solve the disease’s underlying problems. A couple of recently approved drugs designed to target the underlying cause of CF require daily treatment for the entire lifetime and can benefit only a subpopulation of patients with specific types of mutations.

Yet this study has demonstrated that delivering normal copies of CF-related genes or corrective genes via the mucus-penetrating DNA-loaded nanoparticles could mediate production of normal, “functional” proteins long term. This could eventually become an effective therapy for the lungs of patients, regardless of the mutation type.

David Hall's curator insight, August 6, 2015 3:12 AM

Most of the existing drugs for cystic fibrosis (CF), chronic obstructive pulmonary disease, asthma and other life-threatening lung diseases help clear infections but do not solve the disease’s underlying problems. A couple of recently approved drugs designed to target the underlying cause of CF require daily treatment for the entire lifetime and can benefit only a subpopulation of patients with specific types of mutations.

Yet this study has demonstrated that delivering normal copies of CF-related genes or corrective genes via the mucus-penetrating DNA-loaded nanoparticles could mediate production of normal, “functional” proteins long term. This could eventually become an effective therapy for the lungs of patients, regardless of the mutation type.

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New ReWalk™ Personal 6.0 - ReWalk – More Than Walking

New ReWalk™ Personal 6.0 - ReWalk – More Than Walking | Medical Engineering = MEDINEERING | Scoop.it
The new ReWalk Personal 6.0 System is designed for all day use at home and in the community.  It is the most customizable exoskeleton and is configured specifically for you.  This precise fit optimizes safety, function and joint alignment. ReWalk: More Than Walking ReWalk is the most researched exoskeleton and clinical studies* show that standing …
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3-D Engineered Bone Marrow Makes Functioning Platelets

3-D Engineered Bone Marrow Makes Functioning Platelets | Medical Engineering = MEDINEERING | Scoop.it
3-D Engineered Bone Marrow Makes Functioning Platelets
Carlos Garcia Pando's insight:

Platelets can be life-saving or life-threatening. These cells keep us from bleeding to death from injuries by enabling our blood to clot, but they also play a pathological role in heart attacks and strokes, inflammation and cancer. Contained in spongy bones, the bone marrow microenvironment and its "niches" support production of platelets and other blood cells. Mature blood cells pass between the bone marrow and the blood stream through blood vessels containing endothelial cells and extracellular matrix components (ECM) that are important for healthy blood cell production.

The special properties of silk protein were essential to successfully mimicking this microenvironment, explains Kaplan, a leading researcher on silk and other novel biomaterials whose laboratory has bioengineered silk-based models for the brain and other tissue.

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LR launches a JIP in additive manufacturing

LR launches a JIP in additive manufacturing | Medical Engineering = MEDINEERING | Scoop.it

We have launched a joint industry project (JIP) inviting companies from across the world to tackle the current and future issues faced by manufacturers supplying the energy industry – the latest JIP focuses on additive manufacturing.

 

Carlos Garcia Pando's insight:

additive manufacturing is being held back from widespread adoption in safety critical, asset intensive industries. Challenges exist because there is currently no standardised way of proving to manufacturers and regulators that printed products are safe. There are risks associated with consistency and quality control, long term performance, data integrity, intellectual property, and in both software and hardware used in high precision manufacturing – and it is not currently a technology that often can be used for assembly. The safe and sustainable use of powders used in the manufacturing process is also a concern from an environmental and health perspective.

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Medtronic Completes Global User Evaluations for New Insulin Pump Platform

Carlos Garcia Pando's insight:

Medtronic, Inc.  announced it has completed global user evaluations of a next generation system that uses the new pump platform and represents a key step toward development of an artificial pancreas. The completely redesigned insulin delivery system comes with new features that offer convenience in managing diabetes and improved design elements that make the system easy to use.

Medtronic's next generation system uses the new platform along with a new Predictive Low Glucose Management (PLGM) algorithm. PLGM automatically stops insulin delivery when the sensor measures a glucose level predicted to approach the predetermined lowest  limit, and then resumes insulin delivery after those glucose levels recover.  

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Scientists engineer toxin-secreting stem cells to treat brain tumors

Scientists engineer toxin-secreting stem cells to treat brain tumors | Medical Engineering = MEDINEERING | Scoop.it
Proof-of-concept study highlights new therapeutic use of engineered human stem cells
Carlos Garcia Pando's insight:

“A few years ago we recognized that stem cells could be used to continuously deliver these therapeutic toxins to tumors in the brain, but first we needed to genetically engineer stem cells that could resist being killed themselves by the toxins,” he said. “Now, we have toxin-resistant stem cells that can make and release cancer-killing drugs.”

Cytotoxins are deadly to all cells, but since the late 1990s, researchers have been able to tag toxins in such a way that they only enter cancer cells with specific surface molecules; making it possible to get a toxin into a cancer cell without posing a risk to normal cells. Once inside of a cell, the toxin disrupts the cell’s ability to make proteins and, within days, the cell starts to die.

Shah next plans to rationally combine the toxin-secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

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Gene therapy approach to restore vision in people with retinal degenerative conditions

Gene therapy approach to restore vision in people with retinal degenerative conditions | Medical Engineering = MEDINEERING | Scoop.it
RetroSense Therapeutics product development for gene therapies for eye diseases.
Carlos Garcia Pando's insight:

If all goes according to plan, sometime next month a surgeon in Texas will  inject viruses laden with DNA from light-sensitive algae into the eye of a legally blind person in a bet that it could let the patient see again, if only in blurry black-and-white.

 

http://www.retro-sense.com

 

 

 

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Hardwiring the brain to the exoskeleton with a stent.

Hardwiring the brain to the exoskeleton with a stent. | Medical Engineering = MEDINEERING | Scoop.it
Carlos Garcia Pando's insight:

Using the well-established stent technology, they deliver a number of electrodes close to the brain. The electrodes are connected to a computer in the chest (outside the body), and signals are translated into orders to command an exoskeleton.

 

I would prefer an external system, or at least a less intrusive one. But there they go.

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Siemens récompense deux projets d'exosquelette

Siemens récompense deux projets d'exosquelette | Medical Engineering = MEDINEERING | Scoop.it
Siemens récompense deux projets d'exosquelette
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illuminoss: welding bone with a photopolymer

illuminoss: welding bone with a photopolymer | Medical Engineering = MEDINEERING | Scoop.it

IlluminOss’ minimally invasive technology allows for fracture fixation through patient-specific intramedullary implants using a light-curable polymer, contained within a balloon catheter. The percutaneous surgical approach enables surgeons to create a first-of-its-kind patient-conforming implant providing internal support of bones affected by cancer

Carlos Garcia Pando's insight:

The global fracture repair (trauma) market is more than $5 billion and growing greater than 10 percent annually. An aging, active population suffering from osteoporosis contributes to the growing issue of fragility fractures, those occurring as a result of a fall from standing height. Fragility fractures are common in women over 50 years of age and about half will suffer from one in their lifetime.  In men over 50, the occurrence of fragility fractures is one in five. In more dramatic terms, an osteoporotic fragility fracture is estimated to occur every three seconds

Interview with Gene DiPoto, senior vice president of R&D for IlluminOss at http://www.odtmag.com/contents/view_online-exclusives/2015-06-30/illuminoss-aims-to-change-the-standard-of-fracture-repair/

 

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Case Western's BME researchers develop new ways to activate lower limb nerves after paralysis

Case Western's BME researchers develop new ways to activate lower limb nerves after paralysis | Medical Engineering = MEDINEERING | Scoop.it

Researchers with the Advanced Platform Technology (APT) Center of Excellence at Case Western Reserve University and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center have received a $2.6 million award from the National Institutes of Health

Carlos Garcia Pando's insight:

The major innovation of the project is a new way of communicating with the nervous system in the form of a multicontact, microfabrication compatible electrode that matches the dimensions and mechanical properties of the nerves in the lower extremities.  This unique design minimizes the potential for damaging sensitive neural structures while still being able to isolate and activate small sub-portions of the nerves in order to provide precise control of the otherwise paralyzed muscles responsible for moving the hip, knee and ankle joints. 

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New software Tech Automatically ‘Tunes’ Powered Prosthetics While Walking

New software Tech Automatically ‘Tunes’ Powered Prosthetics While Walking | Medical Engineering = MEDINEERING | Scoop.it
Biomedical engineering researchers have developed software that allows powered prosthetics to
Carlos Garcia Pando's insight:

“When a patient gets a powered prosthetic, it needs to be customized to account for each individual patient’s physical condition, because people are different in size and strength. “In addition a patient’s physical condition may change as he or she becomes accustomed to a prosthetic leg, for example, or they may gain weight. These changes mean the prosthetic needs to be re-tuned, and working with a prosthetist takes time and money.”

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Completely paralyzed man voluntarily moves his legs, UCLA scientists report

Completely paralyzed man voluntarily moves his legs, UCLA scientists report | Medical Engineering = MEDINEERING | Scoop.it
Aided by a “robotic exoskeleton” device, the 39-year-old man was able to voluntarily control his leg muscles and take thousands of steps.
Carlos Garcia Pando's insight:

“What we are seeing right now in the field of spinal cord research is a surge of momentum with new directions and approaches to remind the spine of its potential even years after an injury,”

video:  https://youtu.be/tPej2l6dVbw


 

One small step for Human Kind, but a big difference for a man!

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FDA Clearance for joimax EndoLIF On-Cage: 3D-Printed Fusion Implant

FDA Clearance for joimax EndoLIF On-Cage: 3D-Printed Fusion Implant | Medical Engineering = MEDINEERING | Scoop.it
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Carlos Garcia Pando's curator insight, July 18, 2015 11:01 AM

Irvine, California – July 13, 2015 (BUSINESS WIRE) – The German company joimax®, developer of technologies and training methods for minimally invasive endoscopic spinal surgery, today announced it received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market its Endoscopic Lumbar Interbody Fusion, or EndoLIF® On-Cage.

The EndoLIF On-Cage consists of titanium alloy, produced with Electron Beam Melt (EBM) technology. The cage displays a porous surface with diamond cell structure, providing an optimal base for cell proliferation and bone growth. Two large openings, which may be filled with autogenous bone, support the creation of a straight column for fusion.

Two German spine specialists, have already performed more than 200 out of 600 EndoLIF procedures in Europe. 

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Non-Invasive Brain-Machine Interface to Control Prosthetic Hand

Non-Invasive Brain-Machine Interface to Control Prosthetic Hand | Medical Engineering = MEDINEERING | Scoop.it


Non-invasive Technique Allows Amputee to Use Bionic Hand, Powered by His Thoughts

Carlos Garcia Pando's insight:

Although it is fantastic enough to report as it is, this type of application has a very deeper impact. The key is already in the name: BRAIN-MACHINE interface, and the great point in the explanation: it is a snap-on and not a plug-in.

 

How long will it take to extend this for non amputees to run machines, or manufacturing plants through a Snap-on interface?

 

Let's start with a BRAIN-CAR interface, or a BRAIN-DRONE interface, or a BRAIN-SURGICAL ROBOT interface...

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Samsung introduces Look At Me App to Help Children with Autism Communicate Better

Samsung introduces Look At Me App to Help Children with Autism Communicate Better | Medical Engineering = MEDINEERING | Scoop.it
Samsung Electronics Official Blog
Carlos Garcia Pando's insight:

Small scale clinical trial shows 60% improvement in ability to maintain eye contact with people

 

Samsung Electronics introduced its latest initiative to help improve the lives of those with autism. The Look At Me app aims to help develop communication skills in children with autism, with a view to deepening relationships with those around them.

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Amputee Makes History with APL's Modular Prosthetic Limb

Amputee Makes History with APL's Modular Prosthetic Limb | Medical Engineering = MEDINEERING | Scoop.it

 Before putting the limb system through the paces, Baugh had to undergo a surgery at Johns Hopkins Hospital known as targeted muscle reinnervation.

“It’s a relatively new surgical procedure that reassigns nerves that once controlled the arm and the hand,” explained Johns Hopkins Trauma Surgeon Albert Chi, M.D. “By reassigning existing nerves, we can make it possible for people who have had upper-arm amputations to control their prosthetic devices by merely thinking about the action they want to perform.”

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Meniscus Regenerated with 3D-Printed Implant - Columbia University Medical Center

Meniscus Regenerated with 3D-Printed Implant  - Columbia University Medical Center | Medical Engineering = MEDINEERING | Scoop.it
CUMC scientists have created a 3D-printed implant that stimulates stem cells to regenerate the meniscus, cartilage that cushions and protects the knee.
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Carlos Garcia Pando's curator insight, December 11, 2014 4:05 PM

The scaffold is manufactured in polycaprolactone, and infused with two recombinant human proteins: connective growth factor (CTGF) and transforming growth factor β3 (TGFβ3). Dr. Mao’s team found that sequential delivery of these two proteins attracts existing stem cells from the body and induces them to form meniscal tissue.For a meniscus to properly form, however, the proteins must be released in specific areas of the scaffold in a specific order. This is accomplished by encapsulating the proteins in two types of slow-dissolving polymeric microspheres, first releasing CTGF (to stimulate production of the outer meniscus) and then TGFβ3 (to stimulate production of the inner meniscus). Finally, the protein-infused scaffold is inserted into the knee. In sheep, the meniscus regenerates in about four to six weeks. Eventually, the scaffold dissolves and is eliminated by the body.