Unlike the synapt, I personally, do get my hands on the new TQ-S. It lives in Lionel's lab at JIC. I want to use our standard mix of proteins (the quantified UPS2 standard) to see how sensitive I can get it. The objective is to match the demo data.
As this instrument is only being used intermittently the source is general kept closed (arrow down in picture) this nearly caught me out of my first day back on the instrument - these basic gaffes could kill a lot of time! The arrow should be horizonal so that ions (and air) can enter. The little source cone is off here, this is one of the easiest to clean, just a twist pull. Nice :)
A few other little glitches kept my first days interesting; the autosampler had been dropped out of instrument config - that fooled me for a while; getting the blunt-end nano spray fitting together is always fun - without a dead-end stop the two silicon capillary ends grind against each other as they slide in the junction. When I found the correct stop and flushed out the broken glass things went better :)
After a couple of days leaning and fixing the set-up I have a reasonable method for the UPS2 standard mix and - yes! - recreated the demo data test as a bench mark to the orbitrap performance. I am happy to say that, for most peptides, this compares favourably and I can reliably observe the lower abundabce peptides that are not often seen on the orbi.
[edit 25th April '12. Darn - the arrow-error caught me out again *headdesk* Thank you Lionel for spotting this immediately when I complained about getting no signal.)