We report on modifications made to a Paul-type quadrupole ion trap mass spectrometer and discuss its application in infrared ion spectroscopy experiments. Main modifications involve optical access to the trapped ions and hardware and software coupling to a variety of infrared laser sources at the FELIX infrared free electron laser laboratory. In comparison to previously described infrared ion spectroscopy experiments at the FELIX laboratory, we find significant improvements in efficiency and sensitivity. Effects of the trapping conditions of the ions on the IR multiple photon dissociation spectra are explored. Enhanced photo-dissociation is found at lower pressures in the ion trap. Spectra obtained under reduced pressure conditions are found to more closely mimic those obtained in the high-vacuum conditions of an Fourier transform ion cyclotron resonance mass spectrometer. A gas-mixing system is described enabling the controlled addition of a secondary gas into helium buffer gas flowing into the trap and allows for ion/molecule reactions in the trap. The electron transfer dissociation (ETD) option of the mass spectrometer allows for IR structure characterization of ETD-generated peptide dissociation products.
The metabolomes of 260 strains of Pseudomonas were indexed, enabling the discovery and evolutionary relationships of 4 molecules — a poaeamide analogue, and the bananamides 1, 2 and 3 — a molecular sub-family of cyclic lipopeptides.
Scotch Whisky is an important product, both culturally and economically. Chemically, Scotch Whisky is a complex mixture, which comprises thousands of compounds, the nature of which are largely unknown
Beautifull and very well executed example of the use of molecular Isotopic Fine Structures in very complex samples (Scotch Whisky, in this example), to gain insights into the detailed chemical processes. Some of the chemical differences found between Scotch whisky's could be directly related to the ageing, and even the wood of the barrels, used to create the specific whisky flavors.
In essence, this work is along the same lines of research in the Petrol/Petroleomics industry, where these mass spectrometry methods are being used now to study for instance crude oil. Similar methods are starting to be used in several clinical and pharmaceutical analysis, and many other fields.
Together with the already established methods to look at food authenticity with magnetic resonance (NMR - see Bruker wine screener and honey screener products), my personal prediction is that the way we look chemically at all kinds of products will hugely benefit from using these Isotopic Fine Structures to determine these thousands of Chemical Formulae in a very fast way.
Glycosylation pattern within reproductive tract is now suggested to be involved in providing female immune tolerance for allograft sperm and developing embryo, but the information whether impaired glycosylation may influence male fertility...
One of the more significant challenges in forensic toxicology is developing adequate screening methods to detect the broadest range of drugs and poisons possible from complex postmortem biological matrices. In addition, this data must have enough detail to assure the compound has been properly identified, alleviating the possibility of false positives or negatives. Mass spectrometry is an obvious choice for this situation. The next real challenges are the choice of sample introduction technology that could be suitable for the broadest range of compounds and the choice of mass spectrometer that can meet the sensitivity requirements necessary to detect low concentrations in blood and tissue samples. George Hime, Assistant Director of the Miami-Dade Medical Examiner Department Toxicology Laboratory, together with Joe Kahl, Forensic Toxicologist, and Elisa Shoff, Forensic Toxicologist, will demonstrate the value of ion trap mass spectrometry when used as a screening tool in postmortem forensic toxicology. In addition, utilizing GC-MS-MS as a quantitative tool will also be presented. Applications of GC–MS-MS and LC-Ion Trap MS-MS in Postmortem Forensic Toxicology
The new Phenome Centre Birmingham is an eight-million-pound research facility that has been funded by the Medical Research Council, by the University of Birmingham, and by four industry partners, namely, Beckman Coulter, Bruker, ThermoFisher Scientific and Waters. It is a clinical phenotyping centre.
"Inzoomen op zieke cel verkleint kans op tweede ingreep
Met een app zien of je met die moedervlek naar de dokter moet. Door de massaspectrometrie, een innovatieve techniek waarmee je menselijke cellen heel precies kunt fotograferen, lijkt dit de realiteit te worden. Ron Heeren, hoogleraar en fysicus aan de Maastricht University, doet onderzoek naar de technologie en legt uit wat het precies is: 'We proberen de identiteit van deeltjes te bepalen door ze letterlijk te wegen. Elke cel bestaat uit moleculen en die hebben hun eigen massa. Als je die moleculen weegt, weet je welke moleculen de oorzaak zijn van ziekte en gezondheid.' "
The Journal of Biomolecular Screening – Call for Abstracts Special Issue on Advances in MALDI Mass Spectrometry for Drug Discovery Guest editors Shannon Cornett of Bruker and Michael Scholle of SAMDI Tech are seeking manuscript proposals (abstracts) for research and review papers for publication in a 2017 special issue, Advances in MALDI Mass Spectrometry for Drug Discovery. If you are using your Bruker MALDI system for research in related to the topics listed below, this promises to be a high-impact opportunity to present your research results. Submit your abstract by the Sept 30 deadline. image002.png Areas of interest include but are not limited to: · High-throughput MALDI applications, including high density arrays of 384, 1536, 6144, and others. · Use of MALDI in enzyme characterization, such as mechanistic studies, multiple substrate/product analysis, etc. · Applications MALDI and MALDI imaging for metabolite detection and screening · Applications of MALDI and MALDI imaging for drug distribution studies · MALDI applications for characterizing small molecules, including binding and detection · Matrix-Free or laser desorption Ionization applications and techniques · Novel approaches of MALDI to study biological systems and biochemical characterization · Applications of MALDI imaging for early detection of toxicity · MALDI applications for proling cells, cell lines and biochemical samples · MALDI applications for determining metabolism and kinetics
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