Error,Proof Entry, Expert Positioning, and Exploding Growth in Embryonic Stem Cell Products
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Human embryonic stem cells (hESCs) are stem cells derived from the inner cell mass of a blastocyst, which is a stage reached four to five days post-fertilization. Human embryonic stem cells are the most pluripotent of all stem cell types and can develop into over 200 different cell types of the human body.
Human embryonic stem cells were first derived from mouse embryos in 1981 by Martin Evans and Matthew Kaufman, and independently by Gail R. Martin. In 1995, the first successful culturing of embryonic stem cells from non-human primates occurred at the University of Wisconsin-Madison. Another breakthrough followed at the University of Wisconsin-Madison in November 1998 when a group led by Dr. James Thomson developed a technique to isolate and grow hESCs derived from human blastocysts. Federal funds to support hESC research became available on August 9, 2001, when President Bush announced his decision regarding federal funding for hESC research.
Because of their plasticity and unlimited capacity for self-renewal, hESCs have been proposed for use in wide range of applications, including toxicology testing, tissue engineering, cellular therapies, and basic stem cell biology research. Of particular interest to the medical community is the potential for use of hESCs to heal tissues with naturally limited capacity for renewal, such as the human heart, liver and brain. However, human embryonic stem cell research is heavily encumbered by patents held by the University of Wisconsin's Wisconsin Alumni Research Foundation (WARF), which creates significant challenges for companies seeking to develop new products.
This market research report explores the complex IP landscape affecting development of human embryonic stem cell products, providing clear guidance for companies entering or already within the market, from collaborating with WARF to less costly alternatives - such as circumventing the claims, conducting research off-shore, and developing embryonic stem cell products for other species.
The potential medical advances made possible from the use of human embryonic stem cells (hESC) are huge. These stem cells are able to develop into any of over 200 different cell types. So it’s no surprise that the scientific research community is enthusiastically exploring all possibilities.
And where there is significant and growing interest from scientists, there is an opportunity for a company like yours to increase revenue from supplying stem cell products. There is no doubt it’s an exciting market in which to expand your product range. But with embryonic stem cells there are serious market entry barriers to consider – namely a complex intellectual property scene.
Table of Contents :
A. Human Embryonic Stem Cells (hESC)
B. Brief History
C. Use in Treatment of Disease
D. Human Embryonic Stem Cell Line Availability
II. Available Stem Cell Lines
A. NIH Registry Approved
B. Sources of Additional Published hESC Lines
C. Sources of Additional Unpublished hESC Lines
A. Basic Stem Cell Biology
B. Cellular Therapies
2. Heart Regeneration
3. Pancreatic Islet Cell Replacement
4. Neural Regeneration
C. Tissue Engineering
D. Toxicology Testing
IV. Application Priorities
1. Cell-Based Therapies: Greatest shared priority across research community
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