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Early Toxicology: Markets and Approaches

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Early toxicology testing is emerging as one of the mostsignificant areas of drug discovery. Toxicity is no longer something that can be left to the development stage, or just a small part of ADMET. Toxicity determinations are an integral part of all aspects of drug discovery & development.

This report, Early Toxicology Markets and Approaches, focuses on markets for early toxicology testing services. The objective of this report is to focus the reader’s attention on the issues and opportunities related to early toxicology testing in drug discovery. It begins with an overview of drug discovery, ADMET, and early toxicology testing. It continues with some of the ways big pharmaceutical developers dealwith early toxicology. Several areas are covered, including:

For the purposes of reporting market size and growth forecasts, the report segments the market into the following:

In Silico Approaches Databases Data Mining Tools Modeling

In Vitro Assays and Platforms

Biochemical Assays Cellular Assays Instruments & Platforms In Vivo Testing Mice & Traditional Animals Zebrafish Models Other Animals Human Microdosing Early Tox Services In Silico Services In Vitro Services In Vivo Services

Market analysis in this report considers primarily the availabilityof products, number and type of clinical trials active, primary endpoints, anddevelopment of new products. The marketfocuses on the United States region and, where available, discusses the marketglobally. All sales are displayed at the manufacturers’ level in U.S.dollars. Although the sales figures aredisplayed at the manufacturers’ level, in many instances, this figurerepresents a close comparison to the retail level as many end users arepurchasing directly from the manufacturer.The base year is 2011, with forecasts provided for each year through 2016.

Table of Contents :

 

CHAPTER ONE: EXECUTIVE SUMMARY

Drug Discovery: A Complex Process Viox Baycol Rezulin FenPhen Drug Development Summary Scope and Methodology Market Overview Competitors

CHAPTER TWO: INTRODUCTION TO EARLY TOXICOLOGY

Overview The Cost of Drug Development The Role of Contract Research Organizations Toxicology Measurement Issues Alternative Approaches to Early Toxicity

CHAPTER THREE: PHARMA STRATEGIES AND TOXICOLOGY TACTICS

Overview Abbott: Developing Their Own Tools Bristol-Myers Squibb: Reducing Drug Attrition Eli Lilly & Company: In Silico And In Vitro Methods Glaxo Smithkline: Global Safety Board Johnson &Johnson: Alliances And Biomarkers Novartis: Modeling & Simulation Pfizer: Collaborative Approach

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