"PHILADELPHIA —Women who took clomiphene citrate (brand name Clomid) or gonadotropins as a part of fertility treatment did not experience an increased risk for breast cancer over 30 years of follow-up, compared with women who were not treated with these medications, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
"We wanted to evaluate the long-term relationship of fertility medications and breast cancer risk after controlling for other factors that have been shown to be correlated with both breast cancer risk and use of those drugs," said Louise A. Brinton, Ph.D., M.P.H., chief of the Hormonal and Reproductive Epidemiology Branch at the National Cancer Institute (NCI) in Bethesda, Md. "Overall, our data show that use of fertility drugs does not increase breast cancer risk in this population of women, which is reassuring."
An elevated risk for invasive breast cancer was observed for a small number of women who were exposed to 12 or more cycles of clomiphene, who had a little more than 1.5 times the risk of women in the study who never took fertility drugs. Women who were unable to become pregnant after taking gonadotropins and clomiphene citrate had nearly twice the risk of women in the study who never took either medication.
"The observed increase in risk for these small subsets of women may be related to persistent infertility rather than an effect of the medications," said Brinton. "Nevertheless, these findings stress the importance of continued monitoring of women who are exposed to fertility drugs."
Under current practices, clomiphene is usually limited to three to six cycles at doses up to 100 mg, which is far lower than in the past, including patients in this study who were prescribed doses up to 250 mg, oftentimes for many years, explained Brinton.
WASHINGTON (March 29, 2014) — People with celiac disease may have a near two-fold increased risk of coronary artery disease compared with the general population, according to research to be presented at the American College of Cardiology’s 63rd...
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WASHINGTON (March 29, 2014) — It appears healthy postmenopausal women who drink two or more diet drinks a day may be more likely to have a heart attack, stroke or other cardiovascular problems, according to research to be presented at the American...
MADRID, 25 (SERVIMEDIA)El Colegio Profesional de Fisioterapeutas de la Comunidad de Madrid (Cpfcm) informó hoy a través de un comunicado de que más del 40% de los pacientes que sufren enfermedades consideradas como “raras” o “poco frecuentes” en España, necesita un tratamiento continuado de fisioterapia a lo largo de su vida.
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