Blue light exposure is one of the modifiable risk factors involved in the pathogenesis of Age-Related Macular Degeneration (AMD). Several studies have evaluated the relationship between light exposure and AMD, as well as clinical trials evaluated the visual function effect of blue filtering IOLs versus conventional IOLs. However, the authors encourage further clinical trials to assess the preventive filtering effect of ophthalmic lenses, particularly those with narrow bandwidth filters, in the development and/or progression of AMD.
New study results add to growing body of research that HIV-infected patients may experience age-related diseases earlier in life Patients with acquired immunodeficiency syndrome (AIDS) have a four-fold increase in their risk of developing...
Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation | Mutations affecting a nuclear encoded metalloprotease cause of a new form of mitochondriopathy, highlighting the importance of this protease for mitochondrial function in humans.
New research from scientists at the University of Maryland School of Medicine (UM SOM) has found that tiny lumps of calcium phosphate may be an important triggering factor for age-related macular degeneration (AMD), a degenerative eye disease that can cause severe vision loss and blindness. This is the first time these mineral deposits have been implicated in the disease, which affects more than 10 million Americans. The article appeared in the latest issue of the Proceedings of the National Academy of Sciences. This is an image of HAP deposits, surrounded by fat and protein. The HAP is pink, while the surrounding material is green. Credit: UM SOM Biochemist Richard Thompson, PhD, along with his colleague from University College, London, Imre Lengyel, PhD, and a multidisciplinary international team studied retinal samples from a group of elderly patients, some of whom had AMD. They found that the AMD samples contained tiny spherules of a mineralized calcium phosphate known as hydroxyapatite, or HAP. HAP is common in the body - it comprises the hard part of bones and teeth - but it had never been identified in that part of the eye before. AMD develops slowly over decades, with the buildup of fatty protein deposits in the retina, which cause damage by blocking the flow of nutrients into the light-sensitive portion of the eye, and of waste products out. Scientists have known about these deposits for over a century, but their origins remained a mystery. Thompson and Lengyel discovered that the deposits appear to form around the tiny bits of HAP. Once these chunks appear, the fatty protein material coalesces around it; over years, these globules build up. They discovered the possible role of HAP by examining tissue samples from patients using X-ray diffraction and fluorescent staining chemicals.
Eylea (aflibercept) side effects, cost, dosage and prescribing information for age-related macular degeneration (AMD), macular edema following retinal vein occlusion (RVO), diabetic macular edema (DME), and diabetic retinopathy (DR). Includes mechanism, dosing, efficacy, pregnancy, warnings, and financial assistance.
In the past decades, much investigation has been done on the role of lipids in the development and progression of Age-related macular degeneration (AMD). The lipids involved in those research studies had included PUFAs, phospholipids, sphingolipids, cholesterol, lipid protein, etc. .
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What is the food that can really improve your eyesight? Many people suffer declining eyesight as they get older, but is there something we can eat to improve it, asks Michael Mosley. My eyesight has never been good. I’ve worn … Continue reading →
Patients in Bristol suffering from geographic atrophy can now enroll in the phase III clinical program for lampalizumab, a drug being investigated for this form of age-related macular degeneration (AMD). GA is an advanced form of age-related macular degeneration (AMD), a progressive condition which can result in blindness, predominantly affecting people over the age of 70. There are more than 5 million people living with this debilitating condition worldwide and there are currently no approved treatments.1 The CHROMA and SPECTRI phase III clinical trials will evaluate the safety and efficacy and its potential to preserve visual function in people with GA.2 The studies will also further explore if people who have a specific genetic biomarker, complement factor I, may benefit more from the treatment than those who do not.
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