Clinical trials are the cornerstone of developing better cancer care. However, less than 5% of cancer patients participate in clinical trials. A recent meeting of cancer experts developed a list of recommendations for increasing clinical trial enrollment. Strategies at the patient and community level include involving patient advocates and community leaders in clinical trial recruitment, simplifying patient consent forms, and providing interpreters. At the physician level, electronic registries may help keep doctors informed about the availability of clinical trials for their patients. Doctors must also work on speaking to their patients about clinical trials in culturally sensitive ways. Finally, at the level of organizations that initiate clinical trials, institutions need to become more efficient about opening and conducting trials.