Lung Cancer Dispatch
4.6K views | +0 today
Follow
Lung Cancer Dispatch
News for Patients and Physicians
Curated by Cancer Commons
Your new post is loading...
Your new post is loading...
Suggested by Cancer Commons
Scoop.it!

Interim Results from Lung Cancer Clinical Trial of Tivantinib Remain Ambiguous

Interim Results from Lung Cancer Clinical Trial of Tivantinib Remain Ambiguous | Lung Cancer Dispatch | Scoop.it

An ongoing clinical trial is evaluating the effects of cancer drug tivantinib in non-small cell lung cancer (NSCLC). The trial studies patients with advanced non-squamous NSCLC who do not have any mutations in the EGFR gene. Patients receive erlotinib (Tarceva) either by itself or in combination with tivantinib. Enrollment in the trial was stopped because rates of interstitial lung disease (ILD), which can cause lung scarring, may be higher in patients receiving tivantinib. (No such increased levels of ILD were seen in a different trial using tivantinib.) For the patients already enrolled, overall survival, time without cancer worsening, and percentage of patients experiencing tumor shrinkage all seem increased in tivantinib-treated patients. However, it is not yet clear whether these effects are indeed caused by tivantinib or are due to chance.

Cancer Commons's insight:

MarketWatch  |  Jan 16, 2014

more...
No comment yet.
Suggested by Cancer Commons
Scoop.it!

Tarceva May Be More Effective in Advanced NSCLC When Combined with Other Targeted Therapies

Tarceva May Be More Effective in Advanced NSCLC When Combined with Other Targeted Therapies | Lung Cancer Dispatch | Scoop.it

An analysis of multiple clinical trials compared erlotinib (Tarceva) alone to combining Tarceva with other targeted therapies as second-line treatment for advanced non-small cell lung cancer (NSCLC). In the various trials, Tarceva was combined with bevacizumab (Avastin), bortezomib (Velcade), everolimus (Afinitor), sorafenib (Nexavar), sunitinib (Sutent), entinostat, tivantinib, and R1507. While combined therapy produced more side effects, it was more effective than Tarceva alone. Notably, the trials included many patients who had not been tested for mutations in the EGFR and KRAS genes. In patients who had EGFR mutations and/or lacked KRAS mutations, Tarceva alone tended to control cancer progression better than combined therapy, highlighting the importance of biomarker testing to identify which patients are most likely to benefit from different therapies.

Cancer Commons's insight:

PLoS ONE | Feb 8, 2013

more...
No comment yet.
Scooped by Cancer Commons
Scoop.it!

MET Inhibitor Fails to Prolong Life in NSCLC Trial

MET Inhibitor Fails to Prolong Life in NSCLC Trial | Lung Cancer Dispatch | Scoop.it

A clinical trial of a MET inhibitor has been stopped because the drug doesn't keep people with non-small cell lung cancer (NSCLC) alive longer, researchers reported at the 2013 European Cancer Congress in Amsterdam, Netherlands. The phase III trial included 1,048 people with NSCLC, where half were given the MET inhibitor tivantinib, in combination with erlotinib, which inhibits a protein linked to abnormal cell division. Although tivantinib did not extend life, it did keep tumors from growing for awhile (3.6 mo with this drug vs 1.9 mo without it). Now, the researchers are analyzing the results to see if tivantinib benefitted people with tumors that make too much of the MET protein.

Cancer Commons's insight:

European Society For Medical Oncology│Sep 29, 2013

more...
Raja Mudad's curator insight, October 3, 2013 7:27 AM

A new oral drug may help a subset of patients with NS|CL|C who have over expression of cmet

Suggested by Cancer Commons
Scoop.it!

Inhibition of MET May Help Overcome TKI Drug Resistance in Lung Cancer

Inhibition of MET May Help Overcome TKI Drug Resistance in Lung Cancer | Lung Cancer Dispatch | Scoop.it

Tyrosine kinase inhibitors (TKIs) that block EGFR are effective treatments for many cases of advanced non-small cell lung cancer (NSCLC), but are limited by the fact that patients will eventually develop resistance against them. Overexpression of the MET gene may contribute to EGFR-TKI resistance, suggesting that combined inhibition of both EGFR and MET may prevent or overcome this drug resistance. Several MET inhibitors have been developed, including cabozantinib (Cometriq), tivantinib, onartuzumab, and ficlatuzumab, and ongoing trials are investigating the safety and effectiveness of combining them with an EGFR-TKI like erlotinib (Tarceva) or gefitinib (Iressa).


Research paper: http://theoncologist.alphamedpress.org/content/early/2013/01/25/theoncologist.2012-0262.full.pdf

Cancer Commons's insight:

The Oncologist | Jan 28, 2013

more...
No comment yet.