Lung Cancer Dispatch
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Variations in MMP Genes Are Associated with Differences in Lung Cancer Risk

Variations in genes for a family of proteins called matrix metalloproteases (MMPs) have been suggested to play a role in lung cancer risk. A meta-analysis of several studies on MMP genes found that a particular version (or “polymorphism”) of the MMP1 gene, called MMP1-1607 1G/2G, is associated with higher susceptibility for lung cancer in Asian patients. In contrast, the MMP2-1306 C/T version of the MMP2 gene decreases lung cancer risk in Asian patients, and the MMP9-1562 C/T version of the MMP9 gene decreases lung cancer risk in white patients.

 

Research paper: http://www.sciencedirect.com/science/article/pii/S0378111912016447

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Gene | Jan 9, 2013

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Genetic Variation in P53 May Contribute to Lung Cancer Risk

A study of individuals with and without lung cancer in North India found that those carrying a particular version (or “polymorphism”) of a gene for the protein p53 were more likely to have lung cancer, independent of their age or smoking rate. P53 belongs to a class of proteins called “tumor suppressor proteins,” and is involved in DNA repair, regulating cell growth, and inducing cell death in damaged or abnormal cells. The findings suggest that this version of the p53 gene, called Arg72Pro, may contribute to higher susceptibility for lung cancer, at least in the North Indian population.


Research paper: http://online.liebertpub.com/doi/full/10.1089/dna.2012.1792

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DNA and Cell Biology | Jan 14, 2013

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