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Lung Cancer Screening Abnormalities Prompted Smoking Cessation

Lung Cancer Screening Abnormalities Prompted Smoking Cessation | Lung Cancer Dispatch | Scoop.it

"Smokers who received abnormal or suspicious lung cancer screening results were less likely to still smoke at the time of the next year’s screen, according to study results.


"Martin C. Tammemägi, PhD, of the department of health sciences at Brock University in Ontario, Canada, and colleagues reviewed National Lung Screening Trial (NLST) data on 14,692 adults who were current smokers at baseline and did not develop lung cancer during follow-up. The median age of patients was 60.6 years; a majority were men (58.7%) and non-Hispanic white (89.5%)."

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Healio  |  May 28, 2014

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Unraveling the 'Black Ribbon' Around Lung Cancer

Unraveling the 'Black Ribbon' Around Lung Cancer | Lung Cancer Dispatch | Scoop.it

"A study consisting of lung cancer patients, primarily smokers between the ages of 51 to 79 years old, is shedding more light on the stigma often felt by these patients, the emotional toll it can have and how health providers can help. Previous research has shown that lung cancer carries a stigma. Because lung cancer is primarily linked to smoking behaviors, the public's opinion of the disease can often be judgmental. Today, lung cancer remains the leading cause of cancer death globally."

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ScienceDaily  |  Apr 17, 2014

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Inherited Mutated Gene Raises Lung Cancer Risk for Women, Those Who Never Smoked

Inherited Mutated Gene Raises Lung Cancer Risk for Women, Those Who Never Smoked | Lung Cancer Dispatch | Scoop.it

"People who have an inherited mutation of a certain gene have a high chance of getting lung cancer—higher, even, than heavy smokers with or without the inherited mutation, according to new findings by cancer researchers at UT Southwestern Medical Center. Although both genders have an equal risk of inheriting the mutation, those who develop lung cancer are mostly women and have never smoked, the researchers found.


"People with the rare inherited T790M mutation of the epidermal growth factor receptor (EGFR) gene who have never smoked have a one-in-three chance of developing lung cancer, researchers found. This risk is considerably greater than that of the average heavy smoker, who has about a one-in-eight chance of developing lung cancer – about 40- fold greater than people who have never smoked and do not have the mutation."

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Medical Xpress  |  Mar 24, 2014

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Deaths from Lung Cancer Are Decreasing

Deaths from Lung Cancer Are Decreasing | Lung Cancer Dispatch | Scoop.it

Deaths from lung cancer have been decreasing across the U.S., contributing to an overall trend of falling cancer death rates, according to a report coauthored by several major medical and research institutions. Covering the period from 1975 to 2010, the report finds that the decrease in lung cancer deaths has accelerated in recent years. The rate of new lung cancer cases has also fallen, though to a lesser extent. Much of this trend is likely due to the significant reduction in tobacco smoking in past decades, which is producing a delayed effect. The report also showed that the presence of additional illnesses aside from cancer, which can greatly affect outcomes in some other cancer types, has less of an effect on prognosis in lung cancer.

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Medical Xpress  |  Dec 16, 2013

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Long or Ultralong Cigarettes Increase Lung Cancer Risk

Long or Ultralong Cigarettes Increase Lung Cancer Risk | Lung Cancer Dispatch | Scoop.it

Smokers of long or ultralong cigarettes are at greater risk for lung and oral cancer than smokers of regular and king-size cigarettes, a recent study determined. Researchers analyzed urine tests from over 3,500 smokers and found that those who smoked long or ultralong cigarettes had higher levels of tobacco-related carcinogens (cancer-causing substances). Female, black, and older smokers were more likely to smoke long or ultralong cigarettes.

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Medical Xpress | Oct 28, 2013

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Lung Cancer Drug Retaspimycin Fails Clinical Trial

A phase II clinical trial found no survival benefit for the lung cancer drug retaspimycin in non-small cell lung cancer (NSCLC). The trial examined NSCLC patients with a history of smoking who were given the chemotherapy agent docetaxel (Taxotere) either with or without retaspimycin. Adding retaspimycin did not improve overall survival in NSCLC patients in general or in the subset of patients with squamous cell carcinoma (a type of NSCLC closely linked to smoking). The company will complete enrollment in a separate study investigating retaspimycin in combination with everolimus (Afinitor) by the end of 2013, but will begin no further clinical trials with retaspimycin.

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Reuters | Sep 25, 2013

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Genetic Characteristics of Women With Lung Cancer Differ Depending on Smoking History

Few studies so far have focused specifically on lung cancer in women, despite increasing evidence of differences in lung cancer features between women and men. A striking example is the higher rate among women of nonsmokers who develop lung cancer. A recent study of women with lung adenocarcinoma, a type of non-squamous non-small cell lung cancer (NSCLC), found that those who had never smoked were much more likely to have mutations in the EGFR gene and/or abnormally high levels of estrogen receptors, while smokers were more likely to have mutations in the KRAS gene. Based on these findings, a new phase II clinical trial will explore the effectiveness of treating postmenopausal, nonsmoking women who have advanced non-squamous lung cancer with EGFR inhibitors and anti-estrogen drugs.

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International Association for the Study of Lung Cancer | June 24, 2013

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Cancer Patients Need Support to Adopt Healthy Lifestyles

Cancer Patients Need Support to Adopt Healthy Lifestyles | Lung Cancer Dispatch | Scoop.it

Healthy lifestyles can benefit people with cancer, reducing recurrence and increasing long-term survival. But that knowledge alone is not enough to make cancer patients start exercising, and stop smoking and drinking, researchers report in the British Journal of Cancer. The study included 5,146 adults from the English Longitudinal Study of Ageing, and showed that the 433 who got cancer did not adopt healthier habits after diagnosis. Instead, they smoked and drank as much as those without cancer, and exercised even less. The researchers call for figuring out how to help cancer patients make lifestyle changes that can protect their health.

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British Journal of Cancer│May 22, 2013

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British Journal of Cancer│May 22, 2013

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British Journal of Cancer│May 22, 2013

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Smoking Sooner after Waking Is Associated with Higher Lung Cancer Risk

Smokers who have their first cigarette sooner after waking are at higher risk for lung cancer, researchers at Pennsylvania State University found. Those who smoke immediately after waking have higher blood levels of NNAL, a breakdown product of a carcinogen present in tobacco, compared to those who smoke their first cigarette later in the day. The results hold even for those who do not smoke more cigarettes overall. The researchers suggest that smoking soon after waking may reflect greater tobacco dependence, which could lead those smokers to inhale more deeply and absorb more carcinogens. Based on these findings, some future anti-smoking interventions may focus on early-morning, high-risk smokers. Research paper: http://cebp.aacrjournals.org/content/early/2013/03/27/1055-9965.EPI-12-0842.abstract

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Penn State News | Mar 29, 2013

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Wide Variation in Lung Cancer Rates Globally, Study Finds

Wide Variation in Lung Cancer Rates Globally, Study Finds | Lung Cancer Dispatch | Scoop.it

"Lung cancer rates are dropping in young women in many regions of the globe, the only recent comprehensive analysis of lung cancer rates for women around the world finds. The study points to the success of tobacco control efforts around the world. Lung cancer is now the second leading cause of cancer death in women worldwide. An estimated 491,200 women died of lung cancer in 2012, more than half (57%) of whom resided in economically developing countries."

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ScienceDaily  |  May 16, 2014

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ELCC 2014 News: Clinical Utility of miRNA Signature in Plasma of Smokers Included in LD-CT Lung Cancer Screening

"Recent results indicate that low-dose computed tomography (LD-CT) screening reduces lung cancer mortality in high risk subjects. However, high false positive rates, costs and potential harm highlight the need for complementary biomarkers. Led by Dr Ugo Pastorino, a group of researchers from Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, retrospectively evaluated a non-invasive plasma miRNA signature classifier in prospectively collected samples from smokers within the randomised Multicentre Italian Lung Detection (MILD) trial. Their findings indicate that microRNA signature classifier has predictive, diagnostic and prognostic value and its combined use with LD-CT may improve screening performance. The results were presented in a proffered papers session at the 4th European Lung Cancer Conference (26-29 March 2014, Geneva, Switzerland)."


Editor's note: LD-CT is a lung cancer detection method that has been shown to reduce risk of death from lung cancer for high-risk patients. However, it sometimes leads to "false-positives," in which suspected cancer later turns out not to be cancer. A new, non-invasive blood test to look for specific kinds of miRNA molecules was shown to be promising as a potential companion test to complement LD-CT screening.

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ESMO  |  Mar 28, 2014

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E-Cigarette Vapor Promotes Cancer-Like Transformations of Airway Cells with Predisposing Mutations

E-Cigarette Vapor Promotes Cancer-Like Transformations of Airway Cells with Predisposing Mutations | Lung Cancer Dispatch | Scoop.it

E-cigarettes (electronic cigarettes that use a battery-powered system to deliver nicotine without producing smoke) are advertised as a safer alternative to tobacco cigarettes. However, very few studies have investigated how e-cigarettes affect lung function and lung cancer risk. Researchers examined human airway cells with mutations in the TP53 and KRAS genes, which are often mutated in the airways of current or former smokers at high risk of lung cancer. When the cells were exposed to e-cigarette vapor, they developed cancer-cell-like behaviors and gene expression changes very similar to what was seen when these cells were exposed to tobacco smoke. E-cigarettes may increase the risk of developing lung cancer in high-risk people, including current and former tobacco smokers.

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ASCO Post  |  Jan 8, 2014

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Advances in Screening and Surgery Improve Lung Cancer Survival

Advances in Screening and Surgery Improve Lung Cancer Survival | Lung Cancer Dispatch | Scoop.it

New U.S. guidelines recommending low-dose computed tomography (CT) scans to screen for lung cancer in high-risk individuals are leading to earlier detection and better survival for lung cancer patients. Screening is available without a prescription for people who have smoked the equivalent of at least a pack of cigarettes per day for 30 years. The scans can uncover lung cancer in early stages, when the chances for successful treatment are the highest. Recent medical advances have also made lung cancer surgery less invasive. Robotic surgeries can often be performed through small incisions in the chest, without the need to crack open ribs. These developments mean more lung cancer patients can undergo surgery and those who do have an easier recovery.

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Tampa Bay Times  |  Nov 29, 2013

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Internet Use Linked to Cancer-Preventive Behaviors in Older Adults

Internet Use Linked to Cancer-Preventive Behaviors in Older Adults | Lung Cancer Dispatch | Scoop.it

A UK survey found that older individuals who use the Internet are more likely to engage in cancer-preventive behaviors. Adults aged 50 years and older who were regular Internet users were 50% more likely to get screened for colorectal cancer than non-users. They were also more physically active, smoked less, and ate more fruits and vegetables. Younger, wealthier, and more educated respondents were more likely to use the Internet, and fewer women and non-white survey participants used the Internet. However, the link between Internet use and cancer-preventive behaviors remained even after controlling for these factors. Given the apparent beneficial influence of Internet use on cancer outcomes, the survey’s authors urge policymakers to promote better Internet access for currently underserved demographics.

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ScienceDaily | Oct 22, 2013

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ScienceDaily | Oct 22, 2013

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ScienceDaily | Oct 22, 2013

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Pretreatment Interventions May Optimize Outcomes for Cancer Patients

Pretreatment Interventions May Optimize Outcomes for Cancer Patients | Lung Cancer Dispatch | Scoop.it

Interventions given between the time of initial cancer diagnosis and the start of acute cancer treatment—so-called 'prehabilitation'—may improve health outcomes for cancer patients, a review of related studies argues. These interventions can include general physical conditioning, such as aerobic exercise to build strength; specific physical interventions, such as pelvic strengthening exercises before prostate cancer surgery or help quitting smoking before lung cancer treatment; and psychological support. In a number of studies, prehabilitation was shown to reduce treatment complication rates, lead to shorter hospital stays and/or fewer readmissions, improve mental health outcomes, lower health care costs, and make some patients eligible for additional treatment options.

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Medical News Today | Jul 23, 2013

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Medical News Today | Jul 23, 2013

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Medical News Today | Jul 23, 2013

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Cancer Survivors Outside Cities Are Less Healthy

Cancer Survivors Outside Cities Are Less Healthy | Lung Cancer Dispatch | Scoop.it

Cancer survivors in rural areas don't do as well as those in cities and new research suggests the reason may be unhealthy lifestyles. A survey of 1,642 rural and 6,162 urban cancer survivors showed that the former were more likely to smoke (25% vs 16%), be inactive (51% vs 39%), and be unemployed due to poor health (18% vs 11%). The two groups were the same in terms of drinking behaviors and obesity. The U.S. has 2.8 million rural cancer survivors and the researchers recommend tailoring education on healthy behaviors to them.

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Medical News Today│Jun 10, 2013

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Medical News Today│Jun 10, 2013

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Medical News Today│Jun 10, 2013

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Medical News Today│Jun 10, 2013

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Blood Levels of Bilirubin Predict Lung Cancer Risk in Smokers

Blood Levels of Bilirubin Predict Lung Cancer Risk in Smokers | Lung Cancer Dispatch | Scoop.it

Smokers with low blood levels of a molecule called bilirubin are at greater risk of developing lung cancer and dying from it, researchers have found. Among 400,000 people, they found that smokers with the lowest levels of bilirubin had a 69% higher rate of lung cancer and were 76% more likely to die from the disease compared to those with the highest bilirubin levels. Among nonsmokers, differences in bilirubin levels did not affect lung cancer risk. It is not clear whether bilirubin has a protective effect against lung cancer or whether low bilirubin is simply a byproduct of other processes involved in lung cancer development. Either way, low bilirubin levels could identify smokers at high risk of lung cancer who are particularly in need of anti-smoking interventions and cancer screening.

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American Association for Cancer Research | Apr 7, 2013

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American Cancer Society Recommends Lung Cancer Screening for High-Risk Patients

In its newly-released lung cancer screening guidelines, the American Cancer Society recommends that health care professionals discuss lung cancer screening with apparently healthy patients aged 55 to 74 years, who have at least a 30-year history of pack-a-day cigarette smoking, and who currently smoke or have quit within the past 15 years. For these patients, who are at high risk of death from lung cancer, the benefits of being screened for lung cancer annually using a low-dose spiral CT scan outweigh the risks of screening. Lung cancer screening is not recommended for other, lower-risk patients, because abnormal findings on CT scans are often not related to cancer and can lead to unnecessary worry and invasive, potentially harmful, additional diagnostic tests.


Primary source:

http://onlinelibrary.wiley.com/doi/10.3322/caac.21172/full

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American Cancer Society | Jan 11, 2013

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