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ELCC 2014 News: Clinical Utility of miRNA Signature in Plasma of Smokers Included in LD-CT Lung Cancer Screening

"Recent results indicate that low-dose computed tomography (LD-CT) screening reduces lung cancer mortality in high risk subjects. However, high false positive rates, costs and potential harm highlight the need for complementary biomarkers. Led by Dr Ugo Pastorino, a group of researchers from Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, retrospectively evaluated a non-invasive plasma miRNA signature classifier in prospectively collected samples from smokers within the randomised Multicentre Italian Lung Detection (MILD) trial. Their findings indicate that microRNA signature classifier has predictive, diagnostic and prognostic value and its combined use with LD-CT may improve screening performance. The results were presented in a proffered papers session at the 4th European Lung Cancer Conference (26-29 March 2014, Geneva, Switzerland)."


Editor's note: LD-CT is a lung cancer detection method that has been shown to reduce risk of death from lung cancer for high-risk patients. However, it sometimes leads to "false-positives," in which suspected cancer later turns out not to be cancer. A new, non-invasive blood test to look for specific kinds of miRNA molecules was shown to be promising as a potential companion test to complement LD-CT screening.

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ESMO  |  Mar 28, 2014

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CT Scans May Overdiagnose Lung Cancer

CT Scans May Overdiagnose Lung Cancer | Lung Cancer Dispatch | Scoop.it

Low-dose computed tomography (LDCT) scans have emerged as an effective screening tool for lung cancer, especially in high-risk patients. However, the method may have a significant rate of overdiagnosis, that is, detection of cancers that would not have caused any symptoms during the patient’s lifetime. These cancers may be slow growing or otherwise clinically insignificant. Overdiagnosis can lead to unnecessary treatment, generating significant cost and anxiety and risking medical complications. A large study comparing LDCT screening with another screening method, chest radiography, estimated that 18.5% of the lung cancer cases detected represented overdiagnoses. For cases of non-small cell lung cancer (NSCLC) and bronchioalveolar carcinoma (cancer of the air sacs), estimated overdiagnosis rates were 22.5% and 78.9%, respectively.

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Medical News Today  |  Dec 9, 2013

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