Lung Cancer Dispatch
4.6K views | +0 today
Follow
Lung Cancer Dispatch
News for Patients and Physicians
Curated by Cancer Commons
Your new post is loading...
Your new post is loading...
Scooped by Cancer Commons
Scoop.it!

Experimental Breast Cancer Drug to be Trialled in Lung Cancer Patients

Experimental Breast Cancer Drug to be Trialled in Lung Cancer Patients | Lung Cancer Dispatch | Scoop.it

"A clinical trial using an experimental drug originally designed to treat breast cancer launches for patients with advanced lung cancer.


"The drug, called olaparib – a type of treatment called a PARP inhibitor – will be given after chemotherapy to patients with non-small cell lung cancer (NSCLC) to see if it delays the growth of their tumour.


"The phase II trial will recruit over 100 people with advanced non-small cell lung cancer at 25 hospitals around the UK. It is funded by Cancer Research UK and AstraZeneca through a National Cancer Research Network initiative and is being co-ordinated by Cancer Research UK’s Wales Cancer Trials Unit at Cardiff University and Velindre NHS Trust in Cardiff."


Editor's Note: More and more, scientists are finding that different types of cancer (breast and lung cancer, for instance) can sometimes have similarities, meaning that a treatment that works for one type might also work for another type. This study is exploring once such treatment.

Cancer Commons's insight:

Cancer Research UK  |  Mar 11, 2014

more...
No comment yet.
Suggested by Cancer Commons
Scoop.it!

Breast Cancer Drugs May Also Be Effective Against Some Lung Cancers

Breast Cancer Drugs May Also Be Effective Against Some Lung Cancers | Lung Cancer Dispatch | Scoop.it

A class of drugs already in clinical trials for breast and ovarian cancer, so-called PARP inhibitors, may also be effective against some forms of non-small cell lung cancer (NSCLC). Around half of all NSCLC tumors have low levels of ERCC1, a protein that helps repair damaged DNA. PARP inhibitors act by blocking a different DNA repair mechanism. This creates a one-two punch that kills the NSCLC tumor cells that are low in ERCC1, while healthy cells remain relatively unharmed. A recent cell culture study showed that PARP inhibitors like olaparib, niraparib, and BMN 673 killed ERCC1-deficient NSCLC cells, but not cells with normal ERCC1 levels.

Cancer Commons's insight:

Cancer Research UK | Aug 12, 2013

more...
No comment yet.