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Glucophage Linked to Improved Survival for Cancer Patients with Diabetes

Patients with type 2 diabetes are at higher risk of several cancers. However, patients taking the diabetes drug metformin (Glucophage) have a lower risk of developing some kinds of cancer. Now, a review of several studies suggests that Glucophage also improves survival rates for patients who already have cancer. Patients with cancer and diabetes who took Glucophage had a lower risk of death overall, and of dying of cancer specifically, compared to patients receiving other diabetes medications. It is not certain that Glucophage indeed caused the survival benefit. Separate, independent factors could make patients both more likely to be prescribed Glucophage and to have better survival. However, because there is at least a strong possibility of a benefit, the review authors recommend Glucophage as the drug of choice for diabetes patients with cancer.

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Medscape  |  Nov 25, 2013

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Cancer Commons's curator insight, December 2, 2013 12:57 PM

Medscape  |  Nov 25, 2013

Cancer Commons's curator insight, December 2, 2013 12:57 PM

Medscape  |  Nov 25, 2013

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Diabetes Drug May Help Fight Lung Cancer

Diabetes Drug May Help Fight Lung Cancer | Lung Cancer Dispatch | Scoop.it

The diabetes drug metformin may enhance the effectiveness of radiation therapy in non-small cell lung cancer (NSCLC), a recent study concluded. At doses similar to those used in diabetes treatment, metformin slowed the growth of NSCLC cell cultures and made them more sensitive to radiation. It also improved the tumor-shrinking effect of radiation on NSCLC tumors transplanted into mice. These observations suggest that metformin may help prevent or overcome the resistance to radiation that many lung cancer tumors exhibit. The researchers are now working to develop a clinical trial to investigate the benefits of metformin in lung cancer patients receiving radiation therapy.

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Cancer Research UK | May 1, 2013

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Diabetes Drug Glucophage May Make Radiation Therapy More Effective

Diabetes Drug Glucophage May Make Radiation Therapy More Effective | Lung Cancer Dispatch | Scoop.it

Past studies have suggested that the diabetes drug metformin (Glucophage) may make lung cancer tumors more susceptible to radiation, and therefore make radiation therapy more effective. Researchers therefore analyzed the medical records of patients with locally advanced non-small cell lung cancer (NSCLC) who had been treated with radiation and chemotherapy. Sixteen of these patients had been taking Glucophage at the time. All of the Glucophage-treated patients are still alive and the cancer has returned in only two so far (an average of 10.4 months after the treatment)–better outcomes than what was seen in the patients who were not on Glucophage. Glucophage also made tumors more sensitive to radiation treatment in a mouse model of lung cancer.

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ScienceDaily | Oct 23, 2013

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