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Targeted Therapies Might Replace Chemotherapy for Cancer Treatment in the Future

Targeted Therapies Might Replace Chemotherapy for Cancer Treatment in the Future | Lung Cancer Dispatch | Scoop.it

Targeted therapies, drugs that are directed at specific molecular abnormalities in a patient’s cancer, may replace chemotherapy as the treatment of choice for many cancers. Because targeted therapies attack specific pathways that are central to the growth of cancer cells, but often not necessary for the survival of healthy tissues, they usually produce fewer side effects than chemotherapy, which damages both cancerous and healthy cells. Studies documenting better outcomes with chemotherapy-free targeted treatment regimens are emerging for numerous cancers, including melanoma, certain forms of leukemia and lymphoma, and a type of sarcoma called gastrointestinal stromal tumor (GIST). Targeted therapies continue to be limited by the development of drug resistance, an issue that researchers are trying to tackle through combination treatments and new drugs targeting resistant tumors.

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Time | Jun 26, 2013

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Clinical Trials Slated for Treatment that Shrinks All Tumors Tested

Clinical Trials Slated for Treatment that Shrinks All Tumors Tested | Lung Cancer Dispatch | Scoop.it

Last year, a PNAS study showed that the surfaces of many tumor cells have a protein called CD47, which protects them from the immune system. But when these tumors are treated with a drug that inhibits CD47, they get attacked by immune system cells. The researchers transplanted seven kinds of human tumors into mice and treated them with the CD47-targeting drug. All of the tumors—bladder, brain, breast, colon, liver, ovary, and prostate—shrank or disappeared, which kept them from spreading. Now, the research will progress to clinical trials, thanks to a $20 million grant from the California Institute for Regenerative Medicine. CD47 was originally found on leukemia and lymphoma cells; the initial trial will target the stem cells that perpetuate acute myeloid leukemia. This cancer of the blood and bone marrow is fatal within months if untreated, and the 5-year survival rate is only 30% to 40%, even with aggressive treatments including chemotherapy and bone marrow transplants.


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Huffington Post Healthy Living│Apr 3, 2013

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Cancer Commons's curator insight, April 3, 2013 6:49 PM

Huffington Post Healthy Living│Apr 3, 2013

Cancer Commons's curator insight, April 3, 2013 9:21 PM

Huffington Post Healthy Living│Apr 3, 2013