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Inflammation Markers Offer Clue About Lung Cancer Risk

Inflammation Markers Offer Clue About Lung Cancer Risk | Lung Cancer Dispatch | Scoop.it

Increased inflammation may be a warning of elevated lung cancer risk. A recent study analyzed blood samples taken from over 1,000 patients getting screened for lung cancer. Half of the patients went on to develop lung cancer in the following years. Eleven chemical markers of inflammation in the patients’ blood were associated with an increased risk of developing lung cancer. The researchers developed an inflammation score based on the levels of four of these inflammation markers. Patients with the highest inflammation score were 2.8 times more likely to develop lung cancer than those with the lowest score (3.4 times more likely if the patients were current smokers). This inflammation score may therefore serve to identify high-risk patients in the future.

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ASCO Post  |  Dec 9, 2013

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Inflammatory Protein Linked to Lung Cancer

While inflammation is part of the normal immune response, chronic inflammation is linked to many diseases, including cancer. Now, new research shows that white blood cells near non-small cell lung cancers have high levels of a protein that amplifies inflammation. Called TREM-1, this protein is not found in white blood cells from normal lung tissue. These findings were presented at the 2013 meeting of the American College of Chest Physicians. TREM-1 has also been linked to liver cancer and some breast cancers; researchers suspect that this protein helps tumor cells invade tissue and spread to other parts of the body. In addition, recent research shows that TREM-1 can be inhibited with prostaglandins, which are antiinflammatory biomolecules that promote healing.

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Medscape│Oct 30, 2013

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