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Breathalyzer Test May Detect Deadliest Cancer

Breathalyzer Test May Detect Deadliest Cancer | Lung Cancer Dispatch | Scoop.it

"Lung cancer causes more deaths in the US than the next three most common cancers combined. Now a new breathalyzer test, embedded with a 'NaNose' nanotech chip to literally 'sniff out' cancer tumors, has been developed by a team of international researchers. It may turn the tide by both accurately detecting lung cancer and identifying its stage of progression."

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ScienceDaily  |  Jun 18, 2014

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More than 130 Lawmakers Urge Coverage for Lung Cancer Test that Could Cost Medicare Billions

More than 130 Lawmakers Urge Coverage for Lung Cancer Test that Could Cost Medicare Billions | Lung Cancer Dispatch | Scoop.it

"More than 130 lawmakers are urging the Obama administration to expand coverage for a lung-cancer test under Medicare that could cost the program billons, calling the screening important for vulnerable seniors.

"In a letter to the Centers for Medicare and Medicaid Services, the lawmakers called for a timely decision on coverage for low-dose CT scans for older patients at higher risk of developing lung cancer."

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StarTribune  |  Jun 17, 2014

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Improved Diagnostic Performance of Low-Dose Computed Tomography Screening

Improved Diagnostic Performance of Low-Dose Computed Tomography Screening | Lung Cancer Dispatch | Scoop.it

"Investigators of the COSMOS (Continuous Observation of SMOking Subjects) study show good compliance and patient survival outcomes using a 5-year low-dose computed tomography (LDCT) screening protocol in individuals at high-risk of developing lung cancer. This protocol had fewer patients requiring further diagnostic follow-up compared to other studies, including the National Lung Cancer Screening Trial (NLST), with a minimal number of incorrect diagnoses."

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Medical Xpress  |  Jun 16, 2014

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One Step Closer to a Breath Test for Lung Cancer

One Step Closer to a Breath Test for Lung Cancer | Lung Cancer Dispatch | Scoop.it

"A test of organic compounds in exhaled breath can not only distinguish patients with lung cancer from patients with chronic obstructive pulmonary disease (COPD), but can also define the stage of any cancer present, new research shows. The device requires blowing up a balloon, which is then attached to an extremely sensitive gold nanoparticle sensor. The particles in the sensor trap and then help to analyze volatile organic compounds in the exhaled breath."

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ScienceDaily  |  May 31, 2014

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The Ups and Downs of Lung Cancer Screening with Low-Dose CT

The Ups and Downs of Lung Cancer Screening with Low-Dose CT | Lung Cancer Dispatch | Scoop.it

"As a form of cancer that kills 90% of those who develop it, lung cancer is a particularly fearsome adversary to the field of oncology. However, because half of patients with lung cancer have advanced disease at the time of diagnosis, early detection offers hope for reduced mortality.


"To this end, several organizations — including the American Cancer Society (ACS), the National Comprehensive Cancer Network, the American Lung Association (ALA) and the US Preventive Services Task Force (USPSTF) — have updated their lung cancer screening guidelines to suggest screenings with low-dose CT."

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Healio  |  May 21, 2014

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Lung Cancer Screening Would Cost Medicare Billions

Lung Cancer Screening Would Cost Medicare Billions | Lung Cancer Dispatch | Scoop.it

"Implementation of a national lung cancer screening program using low-dose computed tomography (LDCT) will identify almost 55,000 additional lung cancer cases over 5 years, but will add more than $9 billion to Medicare expenditures, according to results of a new study.


"Joshua A. Roth, PhD, of the Fred Hutchinson Cancer Research Center in Seattle, discussed the economic analysis during a press conference in advance of the American Society of Clinical Oncology (ASCO) Annual Meeting, where results will be formally presented at the end of the month. He noted that following the positive results of the National Lung Screening Trial, the US Preventive Services Task Force recently recommended LDCT screening in healthy persons between the ages of 55 and 80 with at least 30 pack-years of smoking history. Medicare, meanwhile, is expected to release a draft decision on screening coverage in November of this year. 'That decision will likely heavily weight the Task Force’s recommendation,' Roth said."

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Cancer Network  |  May 15, 2014

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CMS Advisory Panel Rejects Medicare Coverage for Lung Cancer Screening

CMS Advisory Panel Rejects Medicare Coverage for Lung Cancer Screening | Lung Cancer Dispatch | Scoop.it

"A CMS panel today rejected the concept of national Medicare coverage of annual lung cancer screening for high-risk individuals.


"The Medicare Evidence Development & Coverage Advisory Committee (MEDCAC) conducted a daylong hearing during which several clinicians and members of the public testified about the benefits and risks of lung cancer screening with low-dose CT."

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Healio  |  Apr 30, 2014

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Blood Test Accurate in Later Stage Lung Cancer Diagnosis

Blood Test Accurate in Later Stage Lung Cancer Diagnosis | Lung Cancer Dispatch | Scoop.it

"Simple blood tests for cancer diagnosis and post-treatment assessment are getting closer all the time. New research has shown that a new assay for measuring circulating tumor DNA (ctDNA) could detect essentially all stage II-IV non-small-cell lung cancers (NSCLC), and is even about 50% sensitive in finding stage I NSCLC as well."


" 'Analysis of ctDNA has the potential to revolutionize detection and monitoring of tumors,' wrote investigators led by senior study author Maximilian Diehn, MD, PhD, of Stanford University School of Medicine, in Nature Medicine. 'Noninvasive access to cancer-derived DNA is particularly attractive for solid tumors, which cannot be repeatedly sampled without invasive procedures.' "

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Cancer Network  |  Apr 24, 2014

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Quick, Simple Blood Test for Solid Cancers Looks Feasible

Quick, Simple Blood Test for Solid Cancers Looks Feasible | Lung Cancer Dispatch | Scoop.it

"The idea of a general, quick and simple blood test for a diverse range of cancers just came closer to reality with news of a new study published in Nature Medicine.


"Researchers from Stanford University School of Medicine have devised an ultra-sensitive method for finding DNA from cancertumors in the bloodstream.


"Previous research has already shown circulating tumor DNA holds promise as a biomarker for cancer, but existing methods for detecting it are not sufficiently sensitive and do not cover a diverse range of cancers.


"Ways to increase the sensitivity and coverage of such tests exist, but these are cumbersome and time-consuming, and need lots of steps to customize for individual patients, so they are not feasible for use in clinics.


"The new approach promises to change that. It is highly sensitive and specific and should be broadly applicable to a range of cancers, say the researchers."

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Medical News Today  |  Apr 7, 2014

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Medical News Today  |  Apr 7, 2014

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ELCC 2014 News: Clinical Utility of miRNA Signature in Plasma of Smokers Included in LD-CT Lung Cancer Screening

"Recent results indicate that low-dose computed tomography (LD-CT) screening reduces lung cancer mortality in high risk subjects. However, high false positive rates, costs and potential harm highlight the need for complementary biomarkers. Led by Dr Ugo Pastorino, a group of researchers from Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, retrospectively evaluated a non-invasive plasma miRNA signature classifier in prospectively collected samples from smokers within the randomised Multicentre Italian Lung Detection (MILD) trial. Their findings indicate that microRNA signature classifier has predictive, diagnostic and prognostic value and its combined use with LD-CT may improve screening performance. The results were presented in a proffered papers session at the 4th European Lung Cancer Conference (26-29 March 2014, Geneva, Switzerland)."


Editor's note: LD-CT is a lung cancer detection method that has been shown to reduce risk of death from lung cancer for high-risk patients. However, it sometimes leads to "false-positives," in which suspected cancer later turns out not to be cancer. A new, non-invasive blood test to look for specific kinds of miRNA molecules was shown to be promising as a potential companion test to complement LD-CT screening.

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ESMO  |  Mar 28, 2014

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New Cancer Family History Guidance From ASCO

New Cancer Family History Guidance From ASCO | Lung Cancer Dispatch | Scoop.it

"A new set of recommendations are now available for oncologists on how to collect and utilize the cancer family history of a recently diagnosed cancer patient. The recommendations were released by the American Society of Clinical Oncology (ASCO) and are published in the Journal of Clinical Oncology. This is the first guidance specifically on how oncologists can use family history information to assess whether the patient may have a hereditary form of cancer and to identify those who may have a hereditary predisposition to cancer. The guidelines also review how to refer those patients to appropriate genetic testing and counseling."

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Cancer Network  |  Mar 13, 2014

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Exhaled Compounds Could Provide Accurate Lung Cancer Diagnosis

Exhaled Compounds Could Provide Accurate Lung Cancer Diagnosis | Lung Cancer Dispatch | Scoop.it

"Exhaled breath contains carbonyl volatile organic compounds (VOCs) that can be used as an adjunct to computed tomography (CT) scans in the diagnosis of lung cancer, according to a new study. The breath test could help distinguish between benign and malignant nodules.


" 'The analysis of exhaled breath is a promising noninvasive tool for diagnosis of early lung cancer,” wrote study authors led by Michael Bousamra, MD, of the University of Louisville, in an abstract presented in January at the annual meeting of the Society of Thoracic Surgeons. “Previous techniques have not achieved clinical significance due to a lack of specificity and difficulties related to complex volatile mixtures.' "

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Cancer Network  |  Mar 4, 2014

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Cancer Patients Diagnosed More Quickly

Cancer Patients Diagnosed More Quickly | Lung Cancer Dispatch | Scoop.it

"The time taken to diagnose some of the more common cancers—from the point when a patient first reports a possible symptom to their general practitioner (GP)– fell in adults by an average of five days in just under a decade, according to research published in the British Journal of Cancer."


Editor's Note: In the study, time from first symptoms to cancer diagnosis fell from an average of 125 to 120 days in 7 years, for adults in the UK.

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Cancer Research UK  |  Feb 5, 2014

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Study Investigates Online Information Available to Lung Cancer Patients

Study Investigates Online Information Available to Lung Cancer Patients | Lung Cancer Dispatch | Scoop.it

"Researchers from The University of Manchester have begun a study to look at the online information available to lung cancer patients in an era of diagnosis by google.


"Lung cancer affects around 41,000 people in the UK each year and has one of the lowest survival rates of any cancer, which experts think is partly because people do not get treatment early enough or recognise the symptoms.


"The Medical Research Council-funded study will include a systematic review of the information about lung cancer currently available online to see how this can be improved."

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Medical Xpress  |  Jun 19, 2014

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No Long-Term Anxiety or Distress Associated with Low-Dose Computed Tomography Screening

No Long-Term Anxiety or Distress Associated with Low-Dose Computed Tomography Screening | Lung Cancer Dispatch | Scoop.it

"Examination and review of several studies that evaluated patient-centered outcomes for individuals undergoing low-dose computed tomography (LDCT) screening for lung cancer found that screening does not appear to significantly influence overall health-related quality of life or result in long-term changes in anxiety or distress, but that positive results in the short-term, do increase distress levels."

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Medical Xpress  |  Jun 16, 2014

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Biomarkers Accurately Distinguish Mesothelioma from Non-Cancerous Tissue

Biomarkers Accurately Distinguish Mesothelioma from Non-Cancerous Tissue | Lung Cancer Dispatch | Scoop.it

"Scientists have identified four biomarkers that may help resolve the difficult differential diagnosis between malignant pleural mesothelioma (MPM) and non-cancerous pleural tissue with reactive mesothelial proliferations (RMPs). This is a frequent differential diagnostic problem in pleural biopsy samples taken from patients with clinical suspicion of MPM. The ability to make more accurate diagnoses earlier may facilitate improved patient outcomes. This new study appears in the Journal of Molecular Diagnostics."


Editor's note: Diagnosis of cancer is not always straightforward. New techniques allow doctors to use the molecular/genetic characteristics of a tumor to more quickly and accurately diagnose cancer. In the research described here, scientists identified new molecular characteristics ("biomarkers") that could be used to help identify mesothelioma tumors.

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Medical Xpress  |  Jun 6, 2014

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Bronchial Gene Test Rules Out Lung Cancer

Bronchial Gene Test Rules Out Lung Cancer | Lung Cancer Dispatch | Scoop.it

"Gene analysis of the bronchial airway could reduce unnecessary invasive testing for suspected cases of lung cancer, a study suggested.


"A 17-gene test for normal epithelial cells gathered on bronchoscopy boosted the ability of that procedure to rule out cancer, Duncan Whitney, PhD, of test developer Allegro Diagnostics in Maynard, Mass., and colleagues found."

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MedPage Today  |  May 20, 2014

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Noncalcified Nodules Predicted Long-Term Lung Cancer Risk

Noncalcified Nodules Predicted Long-Term Lung Cancer Risk | Lung Cancer Dispatch | Scoop.it

"Noncalcified nodules conveyed long-term lung cancer risk and acted as cancer precursors, according to study results.


"The findings 'offer support to the idea of utilizing noncalcified nodules as substitute outcomes for chemoprevention,' the researchers concluded."

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Healio  |  May 16, 2014

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Second Opinion Changes Diagnosis from Incurable to Curable Cancer

Second Opinion Changes Diagnosis from Incurable to Curable Cancer | Lung Cancer Dispatch | Scoop.it

"The Journal of Clinical Oncology reports the case of a woman diagnosed with advanced, incurable lung cancer, whose disease was in fact early stage, curable lung cancer with additional lung lesions due to a rare antibiotic side effect. When her primary lung tumor was surgically removed, and the antibiotic stopped, the 62-year-old woman recovered and may now be cured.


" 'In a good example of collaboration with our local oncology community, my colleague wanted a second opinion to ensure his patient got the best possible treatment plan established from the get-go,' said Ross Camidge, MD, PhD, director of the thoracic oncology clinical program at the University of Colorado Cancer Center and the senior author of the study. 'Initially, they were probably looking for some kind of molecular profiling and possibly a novel drug or combination of drugs in a clinical trial. Instead, through some great teamwork, we were able to reveal something unexpected and radically change her prognosis.' "

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Medical Xpress  |  May 12, 2014

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Breath Analysis Offers Non-Invasive Method to Detect Early Lung Cancer

"Researchers are using breath analysis to detect the presence of lung cancer. Preliminary data indicate that this promising noninvasive tool offers the sensitivity of PET scanning, and has almost twice the specificity of PET for distinguishing patients with benign lung disease from those with early stage cancer."

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ScienceDaily  |  Apr 29, 2014

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Sidestepping the Biopsy With New Tools to Spot Cancer

Sidestepping the Biopsy With New Tools to Spot Cancer | Lung Cancer Dispatch | Scoop.it

"For people with cancer or suspected cancer, the biopsy is a necessary evil — an uncomfortable and somewhat risky procedure to extract tissue for diagnosis or analysis.


"Lynn Lewis, a breast cancer patient in Brooklyn, has had her cancer analyzed an easier way: simple blood tests that are being called 'liquid biopsies.'


"Telltale traces of a tumor are often present in the blood. These traces — either intact cancer cells or fragments of tumor DNA — are present in minuscule amounts, but numerous companies are now coming to market with sophisticated tests that can detect and analyze them."

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The New York Times  |  Apr 7, 2014

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Allegro Diagnostics Confirms Clinical Validation of BronchoGen™ Genomic Test for Improved Diagnosis of Lung Cancer in AEGIS-2 Clinical Trial

"Allegro Diagnostics Corp. today announced that the AEGIS-2 clinical trial has met its primary endpoint, demonstrating that the BronchoGen™ genomic test improves the accuracy of lung cancer diagnosis when used in combination with bronchoscopy. BronchoGen is Allegro Diagnostics’ lead genomic test, and it is built upon the company’s molecular testing platform that utilizes gene expression of cytologically normal epithelial cells in the respiratory tract to aid in the diagnosis of lung cancer. Endpoints in the clinical trial include the sensitivity, specificity and negative predictive value of BronchoGen for identifying patients with malignancy. Complete results from the clinical trial will be submitted for publication in a peer-reviewed journal."


Editor's note: Molecular testing of patients' tumor biopsies can be a powerful way to improve diagnosis and guide treatment decisions. Learn more about it.

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Business Wire  |  Apr 2, 2014

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MicroRNA Signature Classifier May Reduce False Positives in Lung Cancer

MicroRNA Signature Classifier May Reduce False Positives in Lung Cancer | Lung Cancer Dispatch | Scoop.it

"A noninvasive plasma microRNA signature classifier combined with low-dose CT was associated with a fivefold reduction in the false-positive rate for lung cancer detection compared with CT alone, according to results of a retrospective study.


"The analysis included 939 smokers enrolled in the Multicenter Italian Lung Detection trial who had been assigned low-dose CT (n=652) or observation (n=287)."


Editor's Note: Sometimes a doctor believes he/she has detected lung cancer in a patient, but the patient is later found not to have lung cancer. This is known as a "false positive." Scientists tested a new lung cancer detection procedure to see if it reduced the risk of false positives. The procedure combines CT scans with molecular testing of a patient's blood sample for substances that could indicate the presence of lung cancer. It found that the new procedure worked better than CT scans alone.

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Healio  |  Mar 19, 2014

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DNA Shed by Tumors Shows Promise for Non-Invasive Screening and Prognosis

DNA Shed by Tumors Shows Promise for Non-Invasive Screening and Prognosis | Lung Cancer Dispatch | Scoop.it

"Certain fragments of DNA shed by tumors into the bloodstream can potentially be used to non-invasively screen for early-stage cancers, monitor responses to treatment and help explain why some cancers are resistant to therapies, according to results of an international study led by Johns Hopkins Kimmel Cancer Center investigators.


"Analyzing blood samples from 640 patients with various cancers, the researchers used digital polymerase chain reaction-based technology (a sophisticated method of multiplying and measuring the number DNA molecules) to evaluate how well the DNA fragments predicted the presence of tumors in the patients."

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Medical Xpress  |  Mar 6, 2014

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Hormone Therapy Linked to Better Survival after Lung Cancer Diagnosis in Women

Hormone Therapy Linked to Better Survival after Lung Cancer Diagnosis in Women | Lung Cancer Dispatch | Scoop.it

"Survival among people with lung cancer has been better for women than men, and the findings of a recent study indicate that female hormones may be a factor in this difference. The combination of estrogen plus progesterone and the use of long-term hormone therapy were associated with the most significant improvements in survival.


"The study was designed to explore the influence of several reproductive and hormonal factors on overall survival of women with non-small cell lung cancer (NSCLC). After adjusting for stage of disease at diagnosis, treatment type (surgery or radiation), smoking status, age, race, and education level, the only factor studied that predicted survival after a diagnosis of NSCLC was use of hormone therapy."

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IASLC  |  Feb 24, 2014

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