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Worse Side Effects from Chemotherapy Experienced When Biological Rhythms Interrupted

"Patients receiving chemical treatment for cancer often suffer fatigue and body weight loss, two of the most worrying effects of this therapy linked to the alteration of their circadian rhythms.


"The circadian system, better known as our biological clock, is responsible for coordinating all the processes that take place in our organism.


"If it does not function correctly, what is known as a circadian disruption or chronodisruption, has for years been linked to an increased incidence of cancer, obesity, diabetes, depression, cognitive problems or cardiovascular diseases."


Editor's note: This research opens up the possibility of personalizing the timing of chemotherapy treatments to minimize side effects.

Cancer Commons's insight:

Medical News Today  |  May 23, 2014

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Cancer Commons's curator insight, May 27, 4:10 PM

Medical News Today  |  May 23, 2014

Cancer Commons's curator insight, May 27, 4:10 PM

Medical News Today  |  May 23, 2014

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Timing Cancer Treatment for Maximum Effectiveness

Timing Cancer Treatment for Maximum Effectiveness | Lung Cancer Dispatch | Scoop.it

Our bodies follow a 24-hour 'biorhythm' that affects most of our biological functions. This fact forms the basis of cancer chronotherapy, which takes time of day into account to plan cancer treatment. Administering cancer drugs at the right time can double effectiveness while reducing toxicity up to fivefold. However, individual differences in biorhythms mean that the 'right time' varies from one person to another. In a recent study, researchers linked gene expression in mice with the time point at which the chemotherapy agent irinotecan (Camptosar) produced the least toxicity. They developed a mathematical model that predicts each animal's ideal time point based on the expression of two genes. In the future, they hope to develop similar tools to help predict the best time for cancer treatment in human patients.

Cancer Commons's insight:

Medical Xpress  |  Nov 22, 2013

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Cancer Commons's curator insight, November 25, 2013 3:05 PM

Medical Xpress  |  Nov 22, 2013

Cancer Commons's curator insight, November 25, 2013 3:05 PM

Medical Xpress  |  Nov 22, 2013