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Palliative Chemotherapy: Harms and Benefits Weighed in New Study

"Palliative chemotherapy is treatment designed for terminal cancer patients to prolong survival and ease symptoms but not cure disease. Now, researchers have found that the therapy comes with certain harms, which they say need to be addressed...


"Overall, the team found that terminal cancer patients who receive chemotherapy during the last months of their lives are less likely to die where they wish and are more likely to undergo invasive medical procedures - including CPR and mechanical ventilation - than patients who did not receive the therapy."

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Medical News Today  |  Mar 5, 2014

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Cancer Commons's curator insight, March 5, 2014 2:21 PM

Medical News Today  |  Mar 5, 2014

Cancer Commons's curator insight, March 5, 2014 2:21 PM

Medical News Today  |  Mar 5, 2014

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Enhancement of Chemotherapy by Prevention of Tumor Cell Repair

"The body naturally tries to repair lesions in the DNA of tumor cells, and thus reduces the efficacy of chemotherapy. Blocking the mechanisms for DNA repair would help to potentiate chemotherapy by reducing the resistance of cells to treatment. A team of scientists has discovered a new drug that inhibits repair: spironolactone, which seems likely to be used in the very short term as an adjuvant to chemotherapy."

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ScienceDaily  |  Feb 20, 2014

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Cancer Commons's curator insight, February 28, 2014 4:51 PM

ScienceDaily  |  Feb 20, 2014

Cancer Commons's curator insight, February 28, 2014 4:52 PM

ScienceDaily  |  Feb 20, 2014

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Meta-Analysis Shows Survival Benefit of Preoperative Chemotherapy in NSCLC

Meta-Analysis Shows Survival Benefit of Preoperative Chemotherapy in NSCLC | Lung Cancer Dispatch | Scoop.it

"In a systematic review and individual patient meta-analysis reported in The Lancet, the NSCLC Meta-analysis Collaborative Group found that neoadjuvant therapy for non–small cell lung cancer (NSCLC) was associated with a significant 13% reduction in risk of death. Significant benefits in recurrence-free survival and time to distant recurrence were also observed...


"Preoperative chemotherapy was associated with a 13% improvement in overall survival.


"Preoperative chemotherapy was associated with a 15% improvement in recurrence-free survival and a 31% improvement in time to distant recurrence."


Editor's Note: "neoadjuvant therapy" refers to chemotherapy given before tumor removal surgery in the hopes of improving the success of the surgery.

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The ASCO Post  |  Mar 4, 2014

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New Treatment Proposed to Prevent Devastating Intestinal Inflammation in Cancer Patients

New Treatment Proposed to Prevent Devastating Intestinal Inflammation in Cancer Patients | Lung Cancer Dispatch | Scoop.it

"Experimental work pointing to a therapy for alleviating mucositis -- a common, severe side effect of chemotherapy and irradiation of cancer patients or patients prepared for bone marrow transplantation – has been achieved by an international team of researchers. Mucositis is a strong inflammatory reaction of the mucosal lining of the digestive system, particularly the gut. Mucositis is often a major reason for premature suspension of anti-cancer therapy. As of today, there has been no effective means of preventing mucositis or its treatment."

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ScienceDaily  |  Feb 18, 2014 

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Cancer Commons's curator insight, February 28, 2014 4:51 PM

ScienceDaily  |  Feb 18, 2014 

Cancer Commons's curator insight, February 28, 2014 4:51 PM

ScienceDaily  |  Feb 18, 2014