Researchers Identify Critical Gene Involved in Lung Cancer Growth | Lung Cancer Dispatch |

Notch genes are a family of genes that are involved in cancer growth. However, they also control many other biological functions, so drugs blocking all Notch genes are severely toxic. Now, researchers have identified one specific member of this gene family that plays a particularly important role in at least some cancers. Inhibiting this gene, Notch1, prevented tumor growth and caused cancer cells to die in both cell culture and animal models of lung adenocarcinoma, a type of non-small cell lung cancer (NSCLC). Drugs selectively targeting Notch1 may offer a less toxic approach to halting lung cancer growth.