Clinical trials at the National Institutes of Health (NIH), the U.S. national medical research agency, continue to enroll patients despite the U.S. government shutdown, but the scope and pace of enrollments have been drastically reduced. More than 13,000 NIH employees, about three-quarters of its workforce, have been forced to take unpaid leave. As a result, in the week since the shutdown, only 12 new participants were admitted to existing trials, compared to around 200 in a typical week. Only patients in imminent danger of dying are being enrolled, most of them cancer patients. No new trials are being started, and at least seven studies have been delayed since the shutdown began.