Lung Cancer Dispatch
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AVEO Oncology Announces Presentation of AV-203 Phase 1 Results at 2014 American Society of Clinical Oncology Annual Meeting

"AVEO Oncology (NASDAQ:AVEO) today announced the presentation of results from a first-in-human Phase 1 study of AV-203, AVEO’s ErbB3 (HER3) inhibitory antibody candidate. Among the results, the study established a recommended Phase 2 dose of AV-203, demonstrated good tolerability and promising early signs of activity, and reached the maximum planned dose of AV-203 monotherapy. The results were presented in a poster, entitled “First-in-human Phase 1 dose-escalation study of AV-203, a monoclonal antibody against ErbB3 in patients with metastatic or advanced solid tumors” (Abstract #11113, Poster #395, S Hall A2), at the Tumor Biology General Poster Session of the American Society of Clinical Oncology 2014 Annual Meeting, taking place May 30 - June 3, 2014, in Chicago."


Editor's note: This story is about a promising new drug called AV-203. In a clinical trial to test the drug in volunteer patients, AV-203 showed promise for treating several cancer types, including lung cancer.

Cancer Commons's insight:

AVEO Oncology  |  May 31, 2014

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Ongoing Clinical Trial Investigates New Lung Cancer Treatment MM-121

Merrimack Pharmaceuticals is conducting a phase II clinical trial of the new drug MM-121. MM-121 is an antibody (a type of immune system protein) that targets a protein called ErbB3 or HER3, which plays a role in tumor growth and survival. ErbB3 is closely related to the protein EGFR. EGFR inhibitors like erlotinib (Tarceva) are used to treat non-small cell lung cancer (NSCLC). The study examines whether combining Tarceva with MM-121 is more effective than Tarceva alone. The trial involves three patients groups: group A (NSCLC patients without mutations in the EGFR gene who have not previously been treated with EGFR inhibitors), group B (patients with EGFR mutations who have not received EGFR inhibitors), and group C (patients who previously received EGFR inhibitors and whose cancer worsened despite the treatment). Group A enrollment has just been completed, group B enrollment is ongoing, and studies of group C were completed recently.

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CNN Money | Apr 29, 2013

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