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Rescooped by Rita Large from Genomic Parasites: Coevolution between host and parasites
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Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity

Diverse transposable elements are abundant in genomes of cellular organisms from all three domains of life. Although transposons are often regarded as junk DNA, a growing body of evidence indicates that they are behind some of the major evolutionary innovations. With the growth in the number of diversity of sequenced genomes, previously unnoticed mobile elements continue to be discovered.

We describe a new superfamily of archaeal and bacterial mobile elements which we denote casposons because they encode Cas1 endonuclease, a key enzyme of the CRISPR-Cas adaptive immunity systems of archaea and bacteria. The casposons share several features with self-synthesizing eukaryotic DNA transposons of the Polinton/Maverick class, including terminal inverted repeats and genes for B family DNA polymerases. However, unlike any other known mobile elements, the casposons are predicted to rely on Cas1 for integration and excision, via a mechanism similar to the integration of new spacers into CRISPR loci. We identify three distinct families of casposons that differ in their gene repertoires and evolutionary provenance of the DNA polymerases. Deep branching of the casposon-encoded endonuclease in the Cas1 phylogeny suggests that casposons played a pivotal role in the emergence of CRISPR-Cas immunity.

The casposons are a novel superfamily of mobile elements, the first family of putative self-synthesizing transposons discovered in prokaryotes. The likely contribution of capsosons to the evolution of CRISPR-Cas parallels the involvement of the RAG1 transposase in vertebrate immunoglobulin gene rearrangement, suggesting that recruitment of endonucleases from mobile elements as ready-made tools for genome manipulation is a general route of evolution of adaptive immunity.

 

 


Via THE_inteins, Gabriel Wallau
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Rescooped by Rita Large from Poetry News
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A Gathering of TWiGS Shortlisted for 2014 PEI Book Awards

A Gathering of TWiGS Shortlisted for 2014 PEI Book Awards | Love everyone, peace | Scoop.it
The latest anthology of Charlottetown’s The Writers in Group (TWiG), titled A Gathering of TWiGS, is shortlisted for the 2014 Prince Edward Island Book Awards in the poetry category. P Susan Buchan...

Via elly
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Rescooped by Rita Large from Arts and Poetry
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Lea Michele Releases 'Brunette Ambition' Audio Book

Lea Michele Releases 'Brunette Ambition' Audio Book | Love everyone, peace | Scoop.it
Glee star Lea Michele recently turned to Twitter to share her excitement over recording the audio version of her new memoir titled 'Brunette Ambition'. The book is available today, May 13, 2014.

Via Grace Christian Kisame K
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Rescooped by Rita Large from Daily Poetry and Stories Portal
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If we Not Happy with what we Got then We will Never be Satisfied. - Jan Jansen

If we Not Happy with what we Got then We will Never be Satisfied. - Jan Jansen | Love everyone, peace | Scoop.it
The post "If we Not Happy with what we Got then We will Never be Satisfied." appear on "English" by Jan Jansen

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Rescooped by Rita Large from Daily Poetry and Stories Portal
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Lets Give our Earth a Better Future Together. - Jan Jansen

The post "Lets Give our Earth a Better Future Together." appear on "English" by Jan Jansen

Via Jan Jansen
Rita Large's insight:

Beautiful, helps everyone

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Nebiyu Hailemichael's comment, September 6, 2013 4:08 AM
This attitude becomes true when we dedicated to change the life of people around us!
Rescooped by Rita Large from Emerging Research in Plant Cell Biology
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Why asparagus makes your urine smell and onions make you cry

Why asparagus makes your urine smell and onions make you cry | Love everyone, peace | Scoop.it
An anonymous chemistry teacher based in the UK created the infographics to demystify the chemistry of everyday foods and show that chemicals are in everything.

Via Meristemi, Andres Zurita, Jennifer Mach
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Marco Fulvio Barozzi's curator insight, May 17, 2014 4:35 PM

La chimica è dovunque, ragazzo mio: devi fartene una ragione.

Rescooped by Rita Large from Poetry and pictures
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15 Black Women Poets Everyone Should Know

15 Black Women Poets Everyone Should Know | Love everyone, peace | Scoop.it

As National Poetry Month comes to a close, we're celebrating these Black women poets who have changed us with their work. They help us to see ourselves and make sense of the world. They inspire us to be better and to make a difference. Here are the 15 Black women poets you should know.

 


Via The Poetry Agent
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Rescooped by Rita Large from Daily Poetry and Stories Portal
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It is Not Difficult to get Things that We Want in Our Life if We can Always be Humble. - Jan Jansen

It is Not Difficult to get Things that We Want in Our Life if We can Always be Humble. - Jan Jansen | Love everyone, peace | Scoop.it
The post "It is Not Difficult to get Things that We Want in Our Life if We can Always be Humble." appear on "English" by Jan Jansen

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Puhloglav Novac's curator insight, February 5, 2014 6:24 AM

ko robot'ki vse štekajo

t'k metuljčki z dlani

polete'  energetsko se

vrti in vpogiba dlani STRASTI

v ljubezni skrite so  dlani

nad _sten' objema robot'kice.....

 

for ANDY NČ_BT

Heather Koroll's curator insight, February 5, 2014 8:53 PM

add your insight...

 
Rescooped by Rita Large from Daily Poetry and Stories Portal
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Love is what can make us Smile when we are Tired. - Jan Jansen

Love is what can make us Smile when we are Tired. - Jan Jansen | Love everyone, peace | Scoop.it
The post "Love is what can make us Smile when we are Tired." appear on "English" by Jan Jansen

Via Jan Jansen
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