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Cancer checkpoint: Mitochondrial metabolic regulator SIRT4 guards against DNA damage

Cancer checkpoint: Mitochondrial metabolic regulator SIRT4 guards against DNA damage | Longevity science | Scoop.it
Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.

 

Researchers studying a set of proteins that regulate physiology, caloric restriction and aging have discovered another important role that one of them plays. SIRT4, one of seven sirtuin proteins, is known for controlling fuel usage from its post in the mitochondria, the cell's energy source. It responds to stressful changes in the availability of nutrients for the cell.

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Muscadinex's curator insight, April 8, 2013 6:29 PM

This is an interesting article on the SIRT4 gene. Resveratrol plays an important part in activating these cells longevity properties.

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Study Uncovers Resveratrol’s Probable Mechanism Of Action - Nutraceuticals World

Study Uncovers Resveratrol’s Probable Mechanism Of Action - Nutraceuticals World | Longevity science | Scoop.it

Resveratrol, how does it work? Unlike previously thought, it does not directly activate sirtuin 1 (protein associated with aging). Instead, it may inhibit other enzymes that help regulate cell energy.

 

"National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits."

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Protein that boosts longevity may protect against diabetes

Protein that boosts longevity may protect against diabetes | Longevity science | Scoop.it

SIRT1, a protein that slows aging in mice and other animals, also protects against the ravages of a high-fat diet, including diabetes, according to a new MIT study.

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Steve Kingsley's curator insight, October 12, 2013 7:24 PM

Somehow I thought high carb - especially refined sugar - diet was the main culprit in developing diabetes. 

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Anti-Aging Protein Extends Life Span in Mice, and Maybe Humans

Anti-Aging Protein Extends Life Span in Mice, and Maybe Humans | Longevity science | Scoop.it
Things are looking up for aging mice and, if this research pays off, for aging humans, too.

 

Researchers have found that a long-suspected anti-aging protein called sirtuin can make male mice live about 16 percent longer than average, the first such advance for mammals in a field that has thus far only offered the blessings of extended life span to yeast, nematodes and fruit flies...

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