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Scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer's / UCLA Newsroom

Earlier this year, researchers identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease.

 

Published in the March 6 issue of the Journal of Alzheimer's Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein.

 

Previous laboratory work by the team demonstrated that specific types of immune cells in Alzheimer's patients may respond to therapy with vitamin D3 and curcumin, a chemical found in turmeric spice, by stimulating the innate immune system to clear amyloid beta. But the researchers didn't know how it worked.

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New stem-cell-derived cells hold promise for Alzheimer’s, other brain diseases | KurzweilAI

In neurodegenerative diseases, the choroid plexus and CPECs age prematurely, resulting in reduced CSF formation and decreased ability to flush out the plaque-forming proteins that are a hallmark of Alzheimer’s.

 

Transplant studies have provided proof of concept for CPEC-based therapies. However, such therapies have been hindered by the inability to expand or generate CPECs in culture.

 

“Our method is promising, because for the first time we can use stem cells to create large amounts of these epithelial cells, which could be utilized in different ways to treat neurodegenerative diseases,” said Monuki, an associate professor of pathology & laboratory medicine and developmental & cell biology at UCI.

 

 

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How vitamin D may help clear amyloid plaques found in Alzheimer’s | KurzweilAI

How vitamin D may help clear amyloid plaques found in Alzheimer’s | KurzweilAI | Longevity science | Scoop.it
UCLA researchers have identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main...
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Scientists successfully treat Alzheimer’s symptoms in mice

Scientists successfully treat Alzheimer’s symptoms in mice | Longevity science | Scoop.it

By turning off an immune system transmitter in mice with an Alzheimer’s-like condition, scientists have been able to greatly reduce the accumulation of an abnormal protein known as amyloid-ß in the animals’ brains.

 

Previous studies have shown that the protein plays a central role in Alzheimer’s disease. It is hoped that the research may ultimately point the way towards a method of preventing or treating the disease in humans.

 

 

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Immune system discovery could lead to a vaccine for heart disease

Immune system discovery could lead to a vaccine for heart disease | Longevity science | Scoop.it
A new understanding of the immune system may be paving the way for the development of a vaccine for heart disease.

 

“If successful, a tolerogenic vaccine could stop the inflammation component of heart disease,” [Dr. Klaus] stated. “This could probably be used in conjunction with the statins (cholesterol-lowering drugs) that have already taken a significant chunk out of the numbers of people with heart disease. Together, they could deliver a nice one-two punch that could be important in further reducing heart disease.”

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