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Metabolic syndrome has declined, some risks persist

Compared to a decade ago, fewer Americans have a cluster of risk factors that together can signal heart troubles and diabetes down the line, according to a new study.

 

But while so-called metabolic syndrome is declining, some of its components - including large waistlines and poor blood sugar control, which carry their own risks - are becoming more common, researchers found.

 

 

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Viagra could prove useful in the fight against obesity

Viagra could prove useful in the fight against obesity | Longevity science | Scoop.it

Researchers from the University of Bonn have treated mice with Viagra and discovered that the drug converts white fat cells (those unwanted denizens of the belly and similar swollen regions) into beige fat cells. Instead of storing excess energy, these recently discovered beige fat cells burn the energy from ingested food and convert it to heat. Viagra also appears (at least in mice) to decrease the risk of other complications caused by obesity.

 

 

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More evidence for obesity paradox

More evidence for obesity paradox | Longevity science | Scoop.it

In a review of almost 100 past studies covering nearly three million people, researchers found that being overweight or slightly obese was linked to about a 6 percent lower risk of dying, compared to people considered "normal weight."

 

 

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Elaine Boardman's curator insight, October 30, 10:37 AM

The relevant idea from this article is not that being slightly overweight lowers risk of dying but that being obese or severely obes increases risk of dying by 18-29 percent.  The cost of that risk is a major factor. Most of those will develop heart issues or diabetes which increases health care costs. There needs to be continuous education on the effect that obesity has on quality of life and healthcare costs--similar to the campaigns on smoking that are now second nature to most of us.

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Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses.

But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2). In their experiments, the scientists discovered that Tyk2 helps regulate obesity in mice and humans through the differentiation of a type of fat tissue known as brown adipose tissue (BAT).
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This discovery may lead to methods to treat obesity by modulating levels of the enzyme. If successful, not only would obesity rates decrease, but healthy life span would increase.

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Red wine compound backed to extend life and reduce food intake ... in bees

Red wine compound backed to extend life and reduce food intake ... in bees | Longevity science | Scoop.it
The red wine compound resveratrol could help to extend life and may even help to battle obesity by 'moderating' food consumption, according to new research ... in bees.

 

The findings showed that bees given resveratrol consumed less food and lived up to 38% longer.

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Gut bacteria play key role in fat absorption: Study (animal)

The presence of certain gut microbes is linked with better digestion and absorption of dietary fats, according to new research that suggests modifying gut bacteria could help to battle malnutrition and obesity.

 

The study was done on fish, not humans. But the mechanism insights may be helpful.

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Manipulating the microbiome could help manage weight

Manipulating the microbiome could help manage weight | Longevity science | Scoop.it
Vaccines and antibiotics may someday join caloric restriction or bariatric surgery as a way to regulate weight gain, according to a new study focused on the interactions between diet, the bacteria that live in the bowel, and the immune system.

 

Researchers examined the complicated relationship between the immune system, gut bacteria, digestion and obesity. They showed how weight gain requires not just caloric overload but also a delicate, adjustable -- and transmissible -- interplay between intestinal microbes and the immune response.

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Researchers identifiy mechanism that turns white fat cells to brown

Researchers identifiy mechanism that turns white fat cells to brown | Longevity science | Scoop.it
Earlier this year, a team from UC San Francisco reported on the discovery that a class of commonly prescribed type-2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of energy-storing white fat cells into energy-burning brown fat cells. Now researchers at Columbia University Medical Center (CUMC) have identified the mechanism that causes this change to take place, potentially leading to new treatments for obesity and type-2 diabetes.

 

While it was known that TZDs have the ability to change white fat cells to brown fat cells by activating a cell receptor called peroxisome proliferator-activated receptor–gamma (ppar-gamma), the exact mechanism behind this transformation was unclear. Because TZDs have numerous adverse side effects,

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Protein that stimulates brown fat could boost weight loss strategies

Protein that stimulates brown fat could boost weight loss strategies | Longevity science | Scoop.it

The ability to activate brown fat in the body could provide a means to fight obesity and keep the weight off.

 

Now scientists have discovered a protein that could allow them to do just that.


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Planes, Trains and Toilets: the Cost of Obesity

Planes, Trains and Toilets: the Cost of Obesity | Longevity science | Scoop.it

The epidemic of obesity is well known. But how well do we understand the costs?

 

With an impact ranging from increased gasoline usage to wider public seats, the cost of obesity has been hidden. Many assume that health care is the budget that suffers the most. However, there are additional costs that will affect everyone.

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Obesity rates rise, threaten health in OECD nations

Obesity rates rise, threaten health in OECD nations | Longevity science | Scoop.it
LONDON (Reuters) - More people in developed countries are overweight or obese than ever before, dooming them to years of ill health, pushing up healthcare costs and piling more pressure on health systems,...

 

While obesity in some countries has stabilized, this is not true in the US and Canada. The cost is high. “Experts say severely obese people die on average eight to 10 years sooner than people at normal weight, with every 15 extra kg increasing risk of early death by around 30 percent.”

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Despite obesity rise, U.S. calories trending downward

U.S. adults have been eating steadily fewer calories for almost a decade, despite the continued increase in obesity rates, according to survey data from the Centers for Disease Control and Prevention (CDC).

 

 

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Too much food can kill you? Overeating and obesity now a bigger global problem than lack of food

Too much food can kill you? Overeating and obesity now a bigger global problem than lack of food | Longevity science | Scoop.it
Chronic diseases linked to obesity and overconsumption of food are now a bigger global healthcare burden than illness and disease caused by malnutrition, according to the most comprehensive disease report ever produced on global health issues.
Ray and Terry's 's insight:

Moderate caloric restriction (reduce your daily caloric intake by 10-20%) can have numerous health benefits. Start by finding your target calorie intake to maintain an optimal weight. If you can stick to that daily level, reduce it by 10%.

 

Fasting is also beneficial. The easiest way? Stop eating at 6-7pm and don't eat again until 6-7am. With minimal effort, you have a 12 hour fast. Plus, you will sleep easier if your digestive system is at rest.

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tiana cherie burne's curator insight, November 3, 11:30 PM

 

For the first time ever, diseases associated with obesity are now more of a global health burden the lack of nutrition. This investigation has been going for 5 years with over 50 scientists exploring the deep issues of obesity. I believe it's a personal decision too eat badly, don't do enough physical activity, drink to much, smoke to many cigars and just don't look after your body the way were meant to. Rising numbers of obesity has been increased with young adults over the years. The biggest global risks effecting people is high blood rate, which is also the biggest neglected global health in most countries.

These scientists thankfully have put out antidotes that have helped save many millions of kids and adults from obesity. We really need more help like this in society, we need to team up and help out each other, were all human no one is special so don't be afraid to ask for help.

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Molecule linking two hormones effectively treats obesity in mice

Molecule linking two hormones effectively treats obesity in mice | Longevity science | Scoop.it

With health authorities saying the world is facing an obesity epidemic and with a recent major study finding that – for the first time – more people now die from obesity-related illnesses like heart attacks and strokes than malnutrition, scientists have been tackling the fat problem.

 

Recent approaches to this problem include looking at ways to slow down the biological clock and converting calorie-storing white fat cells into heat-generating brown fat cells. Now, a new study has found that linking two hormones into a single molecule could lead to improved treatments for medical conditions such as obesity.

 

 

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Diabetes cases hit record and half go undiagnosed

The number of people living with diabetes is now put at 371 million, up from 366 million a year ago, with numbers expected to reach 552 million by 2030, the International Diabetes Federation (IDF) said.

 

Diabetes is often viewed as a western problem, since the vast majority of people have type 2 disease which is linked to obesity and lack of exercise.

 

 

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Health benefits of gastric bypass persist for years

Health benefits of gastric bypass persist for years | Longevity science | Scoop.it

NEW YORK (Reuters Health) - The short-term benefits of weight loss surgery are well known in severely obese people, but a new study finds that improvements in diabetes and blood pressure may hold up for years after the procedures.

 

At six-year patient follow-ups, three quarters of people who'd undergone gastric bypass surgery had lost at least 20 percent of their pre-surgery weight and kept it off, researchers found.

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Vitamin D pills may boost muscle power for overweight people

Vitamin D pills may boost muscle power for overweight people | Longevity science | Scoop.it
Supplementing a resistance training regime with daily doses of vitamin D may improve muscle power and help shed inches from the waistline of overweight and obese people, says a new study.
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New analysis indicates America remains obese

New analysis indicates America remains obese | Longevity science | Scoop.it

Twelve states have obesity rates that top 30 percent, according to an analysis released by the Trust for America’s Health and the Robert Wood Johnson Foundation.

 

The problem is not only that America remains fat, despite the best efforts of governments and activists in recent years, but also that we don’t know for certain whether the country is headed in the right direction.

 

 

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Chemical that slows down the biological clock could lead to new drugs to treat diabetes

Chemical that slows down the biological clock could lead to new drugs to treat diabetes | Longevity science | Scoop.it

Scientists have long suspected that metabolic disorders, such as type 2 diabetes and obesity, could be linked to our circadian rhythm or biological clock. For example, laboratory mice with altered biological clocks often become obese and develop diabetes.

 

Now biologists at UC San Diego have discovered that a chemical, which affects the activity of a key protein that regulates our biological clock, can repress the production of glucose by the liver, offering a promising new direction for the development of a new class of drugs to treat diabetes.

 

A team headed by Steve Kay, dean of the Division of Biological Sciences at UC San Diego, had previously found that altering the levels of a key protein, called cryptochrome – which regulates the biological clocks of plants, insects and mammals and also regulates glucose production in the liver – could improve the health of diabetic mice.

 

Building on that research...

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Delaying Fat Cell Growth

Delaying Fat Cell Growth | Longevity science | Scoop.it

Researchers from Purdue University in Indiana are testing a compound found in red wine that has the ability to block the processes of fat cell development. The research into the compound known as piceatannol may lead towards finding a simple method to combat obesity.

 

Piceatannol results from the conversion of resveratrol – a compound found in red wine, grapes and peanuts that is also thought to combat cancer, heart disease and neurodegenerative diseases. When resveratrol is converted into the piceatannol

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Survey Says: Obesity leveling off & Hawaiians happiest

Survey Says: Obesity leveling off & Hawaiians happiest | Longevity science | Scoop.it

Does this come as a surprise? A recent poll finds that Hawaii is the happiest state and received the best score of wellbeing. Which state scored the lowest?

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