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Longevity science
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Cancer checkpoint: Mitochondrial metabolic regulator SIRT4 guards against DNA damage

Cancer checkpoint: Mitochondrial metabolic regulator SIRT4 guards against DNA damage | Longevity science | Scoop.it
Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.

 

Researchers studying a set of proteins that regulate physiology, caloric restriction and aging have discovered another important role that one of them plays. SIRT4, one of seven sirtuin proteins, is known for controlling fuel usage from its post in the mitochondria, the cell's energy source. It responds to stressful changes in the availability of nutrients for the cell.

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Muscadinex's curator insight, April 8, 2013 6:29 PM

This is an interesting article on the SIRT4 gene. Resveratrol plays an important part in activating these cells longevity properties.

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Delivering drugs via nanoparticles to target mitochondria | KurzweilAI

Delivering drugs via nanoparticles to target mitochondria | KurzweilAI | Longevity science | Scoop.it

Researchers at the University of Georgia have refined the nanoparticle drug delivery process further by using nanoparticles to deliver drugs to a specific organelle within cells.

 

By targeting mitochondria, “the powerhouse of cells,” the researchers increased the effectiveness of mitochondria-acting therapeutics used to treat cancer, Alzheimer’s disease and obesity in studies conducted with cultured cells.

 

 

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New technique replaces diseased DNA, but would give kids two mothers

New technique replaces diseased DNA, but would give kids two mothers | Longevity science | Scoop.it

Scientists hope to prevent mitochondrial disease by removing chromosomes from the eggs of affected women, and putting them into donor eggs.

 

Any children that would be born would not carry the mother’s mitochondrial mutations – but would have the mitochondrial DNA from the woman who donated her eggs.

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