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Promising compound restores memory loss and reverses symptoms of Alzheimer’s | KurzweilAI

Promising compound restores memory loss and reverses symptoms of Alzheimer’s | KurzweilAI | Longevity science | Scoop.it

New research in the FASEB Journal by NIH scientists suggests that a small molecule called TFP5 rescues plaques and tangles by blocking an overactive brain signal, thereby restoring memory in mice with Alzheimer’s — without obvious toxic side effects.

 

“We hope that clinical trial studies in AD patients yield an extended and a better quality of life, as observed in mice upon TFP5 treatment,” said Harish C. Pant, Ph.D., a senior researcher involved in the work from the Laboratory of Neurochemistry at the National Institute of Neurological Disorders at Stroke at the National Institutes of Health.

 

 

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Pacemaker-like device being trialled as Alzheimer's treatment

Pacemaker-like device being trialled as Alzheimer's treatment | Longevity science | Scoop.it
Researchers are investigating the use of pacemaker-like devices for the treatment of Alzheimer’s disease.
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The process of deep brain stimulation involves using a pacemaker-like implanted device to apply controlled mild electrical pulses to specific areas of the brain. In recent studies, it has been used – with some success – to treat conditions such as Parkinson's disease, major depression and Tourette syndrome. Now, in the ADvance Study, researchers at several research centers are exploring its use in restoring memory function to people with Alzheimer’s disease.

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Scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer's / UCLA Newsroom

Earlier this year, researchers identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease.

 

Published in the March 6 issue of the Journal of Alzheimer's Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein.

 

Previous laboratory work by the team demonstrated that specific types of immune cells in Alzheimer's patients may respond to therapy with vitamin D3 and curcumin, a chemical found in turmeric spice, by stimulating the innate immune system to clear amyloid beta. But the researchers didn't know how it worked.

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Secrets of ‘SuperAger’ brains | KurzweilAI

Secrets of ‘SuperAger’ brains | KurzweilAI | Longevity science | Scoop.it
Memory performance on a word list, showing the SuperAgers performed significantly better than elderly controls.

 

Is loss of grey matter an automatic part of aging?

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What can we do to stem the coming Alzheimer's epidemic? (video)

Alzheimer's may strike 100 million people by 2050. Gregory Petsko, Chair of the Department of Biochemistry at Brandeis University, asks: We know our populati...
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Drug To Diagnose Alzheimer’s Disease Receives FDA Approval

Drug To Diagnose Alzheimer’s Disease Receives FDA Approval | Longevity science | Scoop.it

This drug detects and quantifies a particular biological marker for Alzheimer’s. There is still no cure, and the drug is radioactive...

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How vitamin D may help clear amyloid plaques found in Alzheimer’s | KurzweilAI

How vitamin D may help clear amyloid plaques found in Alzheimer’s | KurzweilAI | Longevity science | Scoop.it
UCLA researchers have identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main...
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Alzheimer's Disease Symptoms Reversed in Mice (Scientific American)

Alzheimer's Disease Symptoms Reversed in Mice (Scientific American) | Longevity science | Scoop.it

"A cancer drug given to mice eliminates brain-damaging proteins, leading to improved cognition within days, but will it work in humans?"

 

This cancer drug, Bexarotene, has now been shown to increase levels of APoE. If ongoing study shows that it can increase levels of the E2 allele, that will be more promising for Alzheimer's treatment.

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Toxic interaction in neurons that leads to dementia and ALS | KurzweilAI

Toxic interaction in neurons that leads to dementia and ALS | KurzweilAI | Longevity science | Scoop.it
Researchers at Mayo Clinic in Florida have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia.

The findings shed new light on the link between culprits implicated in two devastating neurological diseases: Alzheimer’s disease and amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, which afflicts physicist Stephen Hawking.

There is no cure for frontotemporal dementia, a disorder that affects personality, behavior and language and is second only to Alzheimer’s disease as the most common form of early-onset dementia.
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Johns Hopkins surgeons implant first brain ‘pacemaker’ for Alzheimer’s disease in US | KurzweilAI

Johns Hopkins surgeons implant first brain ‘pacemaker’ for Alzheimer’s disease in US | KurzweilAI | Longevity science | Scoop.it

Researchers at Johns Hopkins Medicine have surgically implanted a pacemaker-like device into the brain of a patient in the early stages of Alzheimer’s disease, the first such operation in the United States.

 

The device, which provides deep brain stimulation and has been used in thousands of people with Parkinson’s disease, is seen as a possible means of boosting memory and reversing cognitive decline.

 

 

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Quick Test Speeds Search for Alzheimer's Drugs: Compound Restores Motor Function and Longevity to Fruit Flies | ZeitNews

Quick Test Speeds Search for Alzheimer's Drugs: Compound Restores Motor Function and Longevity to Fruit Flies | ZeitNews | Longevity science | Scoop.it
An efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease, according to new research that could help...

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Three coffees a day keeps dementia away, say researchers

Three coffees a day keeps dementia away, say researchers | Longevity science | Scoop.it

In a recent study, maintaining high blood levels of caffeine appeared to help adults over 65 ward off Alzheimer's disease. The study participants started with mild cognitive impairment, but none of the participants with higher blood levels developed Alzheimer's during the 2-4 year period.

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Deep brain stimulation may hold promise for mild Azheimer’s disease | KurzweilAI

Deep brain stimulation may hold promise for mild Azheimer’s disease | KurzweilAI | Longevity science | Scoop.it
A study at the University of Toronto on a handful of people with suspected mild Alzheimer’s disease (AD) suggests that a device that sends continuous electrical impulses to specific “memory” regions of the brain appears to increase neuronal activity.

 

Results of the study using deep brain stimulation, a therapy already used in some patients with Parkinson’s disease and depression, may offer hope for at least some with AD, an intractable disease with no cure.
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Bypassing the blood-brain barrier with MRI and ultrasound | KurzweilAI

Bypassing the blood-brain barrier with MRI and ultrasound | KurzweilAI | Longevity science | Scoop.it

In an experiment that may help develop new ways to treat brain diseases like Alzheimer's and cancer, researchers used MRI, ultrasounds and microbubbles to guide drugs.

 

 

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Eating fewer calories may lower risk of asthma, other diseases

Eating fewer calories may lower risk of asthma, other diseases | Longevity science | Scoop.it
People with asthma may one day receive an unconventional prescription for their condition: eat less.

 

Caloric Restriction (CR) has been studied for years as a method for life extension. This has been proven to work in animal studies, but the results are still unclear in human-- mainly because human lifespan is so much longer than animal lifespan that an adequate study is difficult to engineer. 

 

Now we have evidence that CR may help lower risk of diseases, from asthma to cancer and even Alzheimer's.

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