Longevity science
86
Live longer in good health and you will have a chance to extend your healthy life even further
Follow
Rescooped by Ray and Terry's from Amazing Science onto Longevity science
Scoop.it!

Inhibiting NLK in cancers with mutated PTEN could turn the cancer's strength against it

Inhibiting NLK in cancers with mutated PTEN could turn the cancer's strength against it | Longevity science | Scoop.it

A mutation that allows cells to grow out of control could also provide a new way to target and destroy cancer cells. This potential Achilles’ heel comes from a mutation in a gene called PTEN, which is found in a wide range of cancers.

 

PTEN is one of many tumor suppressor genes that we have to prevent our cells from growing out of control. If the PTEN gene stops working because of a mutation, it can cause tumours to develop – indeed many tumors have a mutated form of PTEN. However when a door closes, a window opens: the PTEN mutation helps the tumor to grow, but it could also mark it out as a target.

 

Researchers from the Institute of Cancer Research, London, found that switching off another gene known as NLK (Nemo-like kinase) killed tumor cells that had the PTEN mutation. This makes NLK a good target for drug developers to create a new cancer treatment.

 

Initially, the researchers took samples of tumor cells with and without the mutation, and switched off genes for important proteins that are used for regulating lots of processes in the cell. To do this they used small interfering RNA (or siRNA) which interfere with the processes of specific genes. These siRNAs block the chain of events that allow a gene to produce a protein, effectively switching it off. By switching off 779 genes individually, they could look for ones where cells with the PTEN mutation died and cells without the mutation survived.

 

This is how the researchers discovered the powerful effect of switching off the NLK gene. They are not certain how this works but it appears to protect a protein called FOXO1 that can act as a backup tumor suppressor and cause the cancer cell to die. When PTEN is mutated, the FOXO1 protein becomes vulnerable to a process called phosphorylation, which means it is ejected from the cell nucleus and destroyed. NLK is one of the proteins that phosphorylates FOXO1 and so by switching off the NLK gene, FOXO1 is able to do its job.

 


Via Dr. Stefan Gruenwald
No comment yet.
Discover Topics Ray and Terry's is following
Amazing Science Biomarkers and Personalized Medicine Singularity Scoops bioinformatics-databases Everything Infographic
Your new post is loading...
Scooped by Ray and Terry's
Scoop.it!

Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation

Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation | Longevity science | Scoop.it

Regular use of glucosamine, chondroitin, or fish oil supplements reduces high-sensitivity C-reactive protein (hs-CRP) by 16% to 22%, a marker of inflammation, according to a new study. Inflammation is now recognized as a factor in cancer and cardiovascular disease as well as many rheumatoid diseases. A number of over-the-counter dietary supplements are being marketed for the purpose of reducing inflammation, but data supporting the claims are limited.

 

To address this situation, Elizabeth D. Kantor, from the Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, and colleagues analyzed data on dietary supplements and hs-CRP in 9947 participants in the National Health and Nutrition Examination Survey. In their article, published online November 8 in the American Journal of Epidemiology, the researchers report that regular use of glucosamine, chondroitin, or fish oil significantly reduced serum hs-CRP.

 

 

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Psychiatric News Alert: Inflammation Biomarker Linked to Depression

Psychiatric News Alert: Inflammation Biomarker Linked to Depression | Longevity science | Scoop.it
Ray and Terry's 's insight:


Elevated levels in a common blood test used to measure inflammation are associated with increased risk for psychological distress and depression, according to Danish researchers writing online December 24 in Archives of General Psychiatry. Their study looked at the medical records of 73,131 people in Copenhagen. Odds ratios of distress, use of antidepressants, and hospitalization for depression were about double that of the general population for people with CRP levels above the standard cutoff of 10 mg/L.

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Free Anti-Inflammation Webcast - Vital Choice

Free Anti-Inflammation Webcast - Vital Choice | Longevity science | Scoop.it

America's diets and lifestyles have created an escalating crisis of chronic inflammatory conditions … including diabetes, arthritis, asthma, allergies, obesity, heart disease, and many others.

 

Floyd “Ski” Chilton, Ph.D., is the author of Inflammation Nation and The Gene Smart Diet … and one of the world’s leading scientists in the field of nutrition and inflammation.

 

We wanted you to know that Dr. Chilton is hosting a free webcast, “3 Steps to Anti-Inflammatory Diet Success”, focused on curbing one key contributor to America’s major disease conditions.

 

Sign up at Vital Choice.

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial

Anthocyanins are pigments found in red/purplish fruits and vegetables, including purple cabbage, beets, blueberries, cherries, raspberries and purple grapes, as well as some cereal grains.

 

A study published in 2012 indicates that anthocyanins help reduce inflammation caused by hypercholesterolemia.

 

Eating a variety of colorful foods, emphasizing fruits and vegetables, is continuously upheld as a strategy to help mitigate disease and maintain a healthy long life.

 

REF:

Nutrition, Metabolism & Cardiovascular Diseases, published online August 20, 2012

Authors:Y. Zhu; W. Ling; H. Guo; F. Song; Q. Ye; T. Zou; D. Li; Y. Zhang; G. Li; Y. Xiao; F. Liu; Z. Li; Z. Shi; Y.

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

How EPA helps the heart

How EPA helps the heart | Longevity science | Scoop.it

How does fish oil protect the heart? The answer to this question has been elusive so far. Scientists know that omega-3 fatty acids exert an anti-inflammatory effect, but the mechanism had not been clearly followed.

 

A new study has now mapped the cellular process occurring after EPA supplementation and found that the nutrient blocks the cyclooxygenase enzyme (COX), which is a precursor to inflammation. COX produces hormones called prostaglandins, which cause inflammation in the body.

 

This is similar to the mechanism of aspirin, which blocks COX-2 signaling, thereby reducing inflammation and pain.

 

Ref: Norris PC, Dennis EA. “Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling.” Proc Natl Acad Sci U S A. 2012 May 14. [Epub ahead of print] PMID: 22586114

 

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Protect your heart with Turmeric

Protect your heart with Turmeric | Longevity science | Scoop.it

Curcumin (extracted from the spice turmeric) is currently one of the most studied natural remedies.

 

A recent controlled study, published in the American Journal of Cardiology involved administering curcumin (or sugar pills) to bypass patients.

 

Those given curcumin pills had significantly lower levels of inflammation and oxidative stress indicators, as well as a 65% reduced risk of heart attack following the bypass surgery.

 

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Fish Oil Linked to Lower Inflammation

Fish Oil Linked to Lower Inflammation | Longevity science | Scoop.it
People sometimes take fish oil hoping that it will help alleviate inflammation-related conditions such as arthritis or allergies. A new epidemiological study supports this long-presumed benefit of seafood-source omega-3s ... whose credibility is bolstered by their proven biological effects. We should note that, with regard to specific conditions, the precise inflammation-related powers of fish oil remain to be proven by high-quality clinical trials.

 

 

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

One in 12 in military has clogged heart arteries

One in 12 in military has clogged heart arteries | Longevity science | Scoop.it

Just over one in 12 U.S. service members who died in the Iraq and Afghanistan wars had plaque buildup in the arteries around their hearts - an early sign of heart disease, according to a new study.

 

None of them had been diagnosed with heart disease before deployment, researchers said.

 

"This is a young, healthy, fit group," said the study's lead author, Dr. Bryant Webber, from the Uniformed Services University of the Health Sciences in Bethesda, Maryland

 

 

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

ScienceDirect.com - Brain, Behavior, and Immunity - Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial

Omega-3 fatty acid supplementation lowered the concentration of inflammatory cytokines in a research study. The data incdicates that maintaining a healthy (higher) ratio of omega-3: omega-6 fats can reduce the impact of aging on cellular health.

 

Inflammation, oxidative stress, and immune cell aging together lead to higher incidence of disease. Nutritional supplementation, including omega-3s can impact and reduce this damage.

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Anti-Inflammatory Drug with a New Benefit to Glucose

In a modern-day clinical trial of a medicine belonging to one of the world's oldest classes of drugs, researchers have found that a drug related to aspirin and salicylate, which was first used by ancient Egyptians and Greeks to ease pain caused by inflammation, also has glucose-lowering properties and may be a potential treatment for people with type 2 diabetes, according to results presented at the American Diabetes Association's 72nd Scientific Sessions(R).

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Blood Cleaning and Filtration

Blood Cleaning and Filtration | Longevity science | Scoop.it

A new device has been tested to clean blood of bacteria.

 

In blood samples tested so far, the scientists have successfully removed 80 and 90 percent of the bacteria Escherichia coli and Saccharomyces cerevisiae, respectively. They have also been able to remove over 80 percent of the blood’s inflammatory...

No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Omega-3 fats tied to less cancer-related fatigue: study

Omega-3 fats tied to less cancer-related fatigue: study | Longevity science | Scoop.it
(Reuters) - Breast cancer survivors who eat a healthy dose of omega-3 fats - found largely in oily fish like salmon, tuna and mackerel - may have some extra energy throughout their day, according to a...
No comment yet.