Longevity science
Follow
Find
72.8K views | +17 today
 
Scooped by Ray and Terry's
onto Longevity science
Scoop.it!

Better approach to treating deadly melanoma identified

Scientists have identified a protein that appears to hold the key to creating more effective drug treatments for melanoma, one of the deadliest cancers.
more...
No comment yet.
Longevity science
Live longer in good health and you will have a chance to extend your healthy life even further
Your new post is loading...
Your new post is loading...
Scooped by Ray and Terry's
Scoop.it!

Mysterious Mechanisms of Cardiac Cell Therapy | The Scientist Magazine®

Mysterious Mechanisms of Cardiac Cell Therapy | The Scientist Magazine® | Longevity science | Scoop.it
In numerous clinical trials, researchers have injected patients with various types of progenitor cells to help heal injured hearts. In some cases, subjects have ended up with better cardiac function, but exactly how has been a subject of disagreement among scientists. According to study on rats published this week (February 2) in Circulation Research, the introduced cells themselves don’t do the job by proliferating to create new muscle.

“These cells do not become adult cardiac myocytes,” said study coauthor Roberto Bolli, a cardiac cell therapy researcher at the University of Louisville School of Medicine. “So the mechanism is clearly a paracrine action, where the cells release ‘something’ which makes the heart better. And the million-dollar question now is, ‘What is the something?’”
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

The Digitalization of Prosthetics Is Transforming How Wounded Service Members and Veterans Recover - Singularity HUB

The Digitalization of Prosthetics Is Transforming How Wounded Service Members and Veterans Recover - Singularity HUB | Longevity science | Scoop.it
Sitting on Dr. Peter Liacouras’s desk is a razor, a stick of deodorant, and a partially built prosthetic arm. Behind him, several 3D printers buzz away, creating contraptions in plastic, nylon, and titanium. Today he is working on creating a custom device that will allow a wounded service member to get ready in the morning by themselves. We take it for granted, but this can be a daunting and consuming task for those who have lost a limb. As the director of service for the 3D Medical Applications Center at Walter Reed National Military Medical Center, Liacouras uses cutting-edge technologies to improve people’s quality of life by pushing the fields of prosthetics and orthotics forward.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Delivering genes across the blood-brain barrier to treat brain diseases | KurzweilAI

Delivering genes across the blood-brain barrier to treat brain diseases | KurzweilAI | Longevity science | Scoop.it
Caltech biologists have modified a harmless virus to allow it to enter the adult mouse brain through the bloodstream and deliver genes to cells of the nervous system.

The modified virus could lead to novel therapeutics to address diseases such as Alzheimer’s and Huntington’s, help researchers map the brain, and target cells in other organs, according to Ben Deverman, a senior research scientist at Caltech and lead author of a paper describing the work in the February 1 online publication of the journal Nature Biotechnology.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

New acoustic-tweezer design allows for 3D bioprinting | KurzweilAI

New acoustic-tweezer design allows for 3D bioprinting | KurzweilAI | Longevity science | Scoop.it
A team of researchers at three universities has developed a way to use “acoustic tweezers” (which use ultrasonic surface acoustic waves, or SAWs, to trap and manipulate micrometer-scale particles and biological cells — see “Acoustic tweezers manipulate cellular-scale objects with ultrasound“) to non-invasively pick up and move single cells in three mutually orthogonal axes of motion (three dimensions).
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

New handheld miniature microscope could ID cancer cells in doctor’s offices and operating rooms | KurzweilAI

New handheld miniature microscope could ID cancer cells in doctor’s offices and operating rooms | KurzweilAI | Longevity science | Scoop.it
A miniature handheld microscope being developed by University of Washington mechanical engineers could allow neurosurgeons to differentiate cancerous from normal brain tissue at cellular level in real time in the operating room and determine where to stop cutting.

The new technology is intended to solve a critical problem in brain surgery: to definitively distinguish between cancerous and normal brain cells, during an operation, neurosurgeons would have stop the operation and send tissue samples to a pathology lab — where they are typically frozen, sliced, stained, mounted on slides and investigated under a bulky microscope.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

How Old Are You, Really? Biological Age Is Harder to Pin Down Than You Think - Singularity HUB

How Old Are You, Really? Biological Age Is Harder to Pin Down Than You Think - Singularity HUB | Longevity science | Scoop.it
Scientists are increasingly making the distinction between your chronological age — the number of years that you’ve lived — and your biological age.

It’s not just an academic curiosity. A 2015 study, which comprehensively analyzed the function of multiple body systems of nearly 1,000 young adults, found that a 38-year-old’s biological clock can read anywhere from a spritely 20 to a feeble 60.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

A Diabetes Technology Revolution — Medium

A Diabetes Technology Revolution — Medium | Longevity science | Scoop.it
Wearable, needle-free blood sugar monitoring is becoming a reality through contact lenses and other innovative ideas, such as temporary tattoos with sensors and low-power lasers that detect blood sugar levels through the skin. Patients will be able use their smartphones to track their readings and get advice about their diet and exercise. The information will be stored in the cloud, where users and their healthcare team can download it at any time.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

CRISPR/Cas9 Genome Editing Is a Huge Deal, But It’s Just the Tip of the Iceberg - Singularity HUB

CRISPR/Cas9 Genome Editing Is a Huge Deal, But It’s Just the Tip of the Iceberg - Singularity HUB | Longevity science | Scoop.it
An estimated 6,000 diseases are caused by genetic mutations, and only 5% can be treated. Take sickle-cell anemia, for example. Often deadly, it is caused by a single mutation in one of the human body’s three billion DNA base pairs. It’s a small, well-understood error in the genetic code, but so far we have been helpless to repair it.

The CRISPR/Cas9 system, often described as a pair of DNA scissors, could zero in on the troublesome base pairs causing sickle-cell anemia, and replace them.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Electrically-trained muscle cells get damaged hearts pumping

Electrically-trained muscle cells get damaged hearts pumping | Longevity science | Scoop.it
Repairing damaged hearts with healthy cells derived from stem cells is a promising approach to tackling cardiovascular disease, but it does have its limitations. Difficulty in getting the young, freshly implanted cells to integrate and beat in-synch with the surrounding muscle has so far held the technique back. Now scientists are reporting an important advance in this area, demonstrating for the first time that electrically stimulating the new cells can give their development a critical boost.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Reveling in the Revealed | The Scientist Magazine®

Reveling in the Revealed | The Scientist Magazine® | Longevity science | Scoop.it
Which parts of the genome are available for transcription at a given moment? ENCODE helped answer this question by using DNase-seq, a technique that digests and sequences nucleosome-free regions of the genome. Similar methods have come along in recent years, including ATAC-seq and MNase-seq, expanding researchers’ options for taking snapshots of available (or unavailable) DNA.

Surveying the whole genome using these methods can be a helpful first step toward cataloging potential functional elements of transcription. ChIP-seq (or its myriad variations) may then provide more mechanistic insights, by using antibodies to pinpoint specific transcription factors, notes senior investigator Keji Zhao of the National Heart, Lung, and Blood Institute.


The Scientist talked to developers and users about the pros and cons of each of these commonly used techniques. Here’s what they said.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

SINGAPORE RESEARCHERS DEVELOP WORLD’S FIRST HIGH-THROUGHPUT IMAGING PLATFORM FOR PREDICTING KIDNEY TOXICITY

SINGAPORE RESEARCHERS DEVELOP WORLD’S FIRST HIGH-THROUGHPUT IMAGING PLATFORM FOR PREDICTING KIDNEY TOXICITY | Longevity science | Scoop.it
Automated cellular imaging platform efficiently and accurately predicts toxicity of chemical compounds paving the way toward safer products

Singapore — Researchers at A*STAR’s Bioinformatics Institute (BII) and the Institute of Bioengineering and Nanotechnology (IBN) have developed a highly efficient and accurate cellular imaging platform for predicting the toxicity of compounds to the kidney. The approach, which combines cell culture, imaging and computational methods, could prove invaluable to companies from the food, nutrition, cosmetics, consumer care, chemical and pharmaceutical industries by enabling them to predict the safety of their products while in development.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Cloaking chemo drugs in cellular bubbles destroys cancer with one fiftieth of a regular dose

Cloaking chemo drugs in cellular bubbles destroys cancer with one fiftieth of a regular dose | Longevity science | Scoop.it
The chemotherapy drug paclitaxel is commonly used to treat breast, lung and pancreatic cancers, slowing their growth by preventing cancerous cells from replicating. But once administered the drug is attacked by the body's defenses, necessitating larger doses that result in complications such as joint pain, diarrhea and an impaired ability to fend off other infections. Researchers have now discovered a way to sneak the drug through to the tumor with its entire payload intact, a technique that could make for more effective cancer treatments with fewer side effects.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Got matcha? Five healthy foods that will make their mark on 2016.

Got matcha? Five healthy foods that will make their mark on 2016. | Longevity science | Scoop.it
Matcha is extremely rich in catechins, the active compounds found in green tea known to have beneficial health properties, and it adds a stunning color to all it touches. It hasn’t been studied well enough to confirm that it is significantly better for you than other types of green tea, and it’s not magic — adding it to cakes and macaroons doesn’t make those foods healthy — but it is an easy, appealing and different way to get healthy green tea into your life.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Mayo Clinic researchers extend lifespan by up to 35 percent in mice | KurzweilAI

Mayo Clinic researchers extend lifespan by up to 35 percent in mice | KurzweilAI | Longevity science | Scoop.it

Researchers at Mayo Clinic have discovered that senescent cells — cells that no longer divide and accumulate with age — shorten lifespan by as much as 35 percent in normal mice.

Removing these aging cells delays tumor formation, preserves tissue and organ function, and extends lifespan without observed adverse effects, the researchers found, writing Feb. 3 in Nature.

...


As the immune system becomes less effective, senescent cells build up and damage adjacent cells, causing chronic inflammation, which is closely associated with frailty and age-related diseases.

more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Circadian Clock and Aging | The Scientist Magazine®

Circadian Clock and Aging | The Scientist Magazine® | Longevity science | Scoop.it

Embryonic deletion of a core circadian clock gene, Bmal1, leads to problems associated with accelerated aging in adult mice, including neurodegeneration, poor hair growth, eye and bone pathologies, and a decreased lifespan. Yet mice in which the gene is knocked out after birth don’t exhibit many of these aging-related phenotypes, according to a study published today (February 4) in Science Translational Medicine. The results suggest that the circadian clock gene plays different roles during embryogenesis and after birth.


“This is a thorough and well-conducted study,” said Ghislain Breton, who studies the circadian system at the University of Texas Health Science Center in Houston, but was not involved in the work. “The lesser phenotype when you disrupt Bmal1 after birth is very intriguing,” he continued. “It means that certain early developmental stages are likely more sensitive to circadian clock disruptions compared to adulthood.”



more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Improved DNA tech could replace antibodies in detecting and treating diseases

Improved DNA tech could replace antibodies in detecting and treating diseases | Longevity science | Scoop.it
A team of researchers from the Institute of Bioengineering and Nanotechnology at the Agency for Science, Technology and Research (A*STAR) has worked to develop an efficient technology that uses DNA to detect and treat infectious diseases. Improving upon an existing method, the research makes use of single-stranded DNA molecules called aptamers, and it could be used to treat cancer.

Aptamers are good candidates for the development of new treatments, as they have an innate ability to bind to any molecule they're targeted at, including cancer cells and bacteria. Once bound to a target, the aptamer inhibits its activity, eliminating the threat it poses to the host.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Natural food additive found to block skin cancer cells in mice

Natural food additive found to block skin cancer cells in mice | Longevity science | Scoop.it
Derived from the achiote tree, annatto has been a source of lipstick, body makeup, and cooking ingredients for native Americans since the pre-Columbian era. Now it is used as a common food additive for things like cheese, butter and margarine.

Scientists working at the University of Arizona College of Pharmacy have now discovered that it may also have a role to play in tackling skin cancer. Associate professor Georg Wondrak hunts for small molecules that can prevent the cancer by activating the Nrf2 pathway, which strengthens the body's cells against exposure to carcinogens.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Medical - Gizmag

Medical - Gizmag | Longevity science | Scoop.it
Our body has controls in place to regulate how cells grow and divide, which is a particularly useful mechanism in preventing the spread of disease. But when it comes to acute myeloid leukaemia (AML), an aggressive form of blood cancer, these controls are neutralized, giving the cancer cells free rein to multiply and grow uncontrollably. Australian researchers have now discovered a protein that drives this process, and have shown that by blocking its activity they might be able to stop the deadly form of cancer in its tracks.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Ranks of U.S. centenarians growing rapidly: report

Ranks of U.S. centenarians growing rapidly: report | Longevity science | Scoop.it
The number of Americans living beyond their 100th birthday has surged nearly 44 percent since the turn of the century, a U.S. study released on Thursday showed.

Better medical care and healthier lifestyles helped to boost U.S. centenarians' ranks to 72,197 in 2014 from 50,281 in 2000, the Centers for Disease Control and Prevention report said. More than 80 percent of the centenarians were female.

The numbers should keep rising, since the death rate for centenarians has fallen since 2008, noted the study's author, Jiaquan Xu. Some projections show there could be 387,000 U.S. centenarians in 35 years, he noted.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Researchers pinpoint ‘limbo’ noisy place where cancer cells may emerge | KurzweilAI

Researchers pinpoint ‘limbo’ noisy place where cancer cells may emerge | KurzweilAI | Longevity science | Scoop.it
In a study involving the fruit fly equivalent of an oncogene implicated in many human leukemias, Northwestern University researchers have gained insight into how developing cells normally switch to a restricted, or specialized, state and how that process might go wrong in cancer.

The fruit fly’s eye is an intricate pattern of many different specialized cells, such as light-sensing neurons and cone cells. Because flies share with humans many of the same cancer-causing genes, scientists use the precisely made compound eye of Drosophila melanogaster (the common fruit fly) as a workhorse to study what goes wrong in human cancer.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Dissolvable sensors could soon be used to wirelessly monitor the human brain

Dissolvable sensors could soon be used to wirelessly monitor the human brain | Longevity science | Scoop.it
The team set out with one clear goal – to create a sensor that can be placed in the brain, is completely wireless and, once its job is done, dissolves away entirely. The device they built is made chiefly from silicone and polylactic-co-glycolic acid (PLGA), and is smaller than the tip of a pencil. It's able to wirelessly transmit accurate temperature and pressure data, and the researchers believe that it could be easily adapted for use in other organs around the body.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Digital Diagnosis: Intelligent Machines Do a Better Job Than Humans - Singularity HUB

Digital Diagnosis: Intelligent Machines Do a Better Job Than Humans - Singularity HUB | Longevity science | Scoop.it
The use of medical robots to assist human surgeons is becoming more widespread but, so far, they are being used to try and improve patient outcomes and not to reduce the cost of surgery. Cost savings may come later when this robotic technology matures.

It is in the area of medical diagnostics where many people see possible significant cost reduction while improving accuracy by using technology instead of human doctors.

It is already common for blood tests and genetic testing (genomics) to be carried out automatically and very cost effectively by machines. They analyze the blood specimen and automatically produce a report.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

L-Arginine - Heart Health - Products

Exercise, particularly intense exercises like sprinting, demands additional energy from the body. This energy need produces additional lactates, which can increase muscle pain. Arginine supplementation enhances exercise endurance while it reduces the heart rate and reduces circulating lactates.2
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

To Cure Cancer, Biden Says Have To Overcome 'Cancer Politics'

To Cure Cancer, Biden Says Have To Overcome 'Cancer Politics' | Longevity science | Scoop.it
As one of his final acts in office, Biden has resolved to "break down silos" he says are pervasive throughout the sprawling and fragmented world of oncologists, scientists and benefactors. Meetings with nearly 200 of them revealed a community rife with competition, territorialism and resistance to information-sharing that's left researchers and their discoveries cloistered in their own corners, aides and others who met with Biden said.

Asked how Americans could help, Biden minced no words: "Demand collaboration from the scientific community," he wrote on Twitter.
more...
No comment yet.
Scooped by Ray and Terry's
Scoop.it!

Blind Woman Receives Bionic Eye, Reads a Clock With Elation - Singularity HUB

Blind Woman Receives Bionic Eye, Reads a Clock With Elation - Singularity HUB | Longevity science | Scoop.it
The images she sees are not seamless—objects are grainy and appear only in black and white—though the implant is indeed life altering for the blind.

“It’s been maybe eight years that I’ve had any sort of idea of what my children look like,” Lewis told The Guardian. “Now, when I locate something, especially like a spoon or a fork on the table, it’s pure elation. I just get so excited that I’ve got something right.”

Bionic eye technology isn’t new, though this is one of the best versions to date.
more...
No comment yet.