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Cancers Delete Suppressing Genes on Chromosomes - Softpedia

Cancers Delete Suppressing Genes on Chromosomes - Softpedia | Longevity science | Scoop.it

Numerous cancer types are known to have an influence on human chromosomes, deleting certain portions in order to be able to infect the body. Now, researchers have shown that some of these deleted sections contain clusters of tumor-suppressing genes.

 

Experts say that this has been suspected for quite some time, but that evidence to prove that this was indeed the case has been lacking. The new investigation looked at a copy-number alteration (CNA), a deletion that occurs on the short arm of chromosome 8 (8p).

 

The study was carried out on mouse models of human liver cancer. Researchers found that this specific CNA affected a series of genes that work together to counteract tumors as soon as they start evolving.

 

 

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Panasonic's robotic bed/wheelchair first to earn global safety certification

Panasonic's robotic bed/wheelchair first to earn global safety certification | Longevity science | Scoop.it

There's a lot of talk about Japan's rapidly aging society, and how it is expected to literally place a heavy burden on the island nation's caregivers. Among the many projected problems is a smaller pool of health care workers amidst a growing tide of elderly who require around-the-clock care. With that kind of workload, nurses are more likely to injure themselves or their patients when lifting them into and out of bed.


Various solutions are in the works, such as a giant lifting robot that looks like a teddy bear, but few are as practical as Panasonic's Resyone robotic bed. It recently became the first to be certified ISO13482 compliant, the new global safety standard for service robots.



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Lab-grown cartilage used to perform nose reconstruction surgery

Lab-grown cartilage used to perform nose reconstruction surgery | Longevity science | Scoop.it

Researchers from Switzerland's University of Basel have performed the first successful nose reconstruction surgery using engineered cartilage grown in the laboratory. The cartilage was spawned form the patient's own cells in an approach that could circumvent the need for more invasive surgeries.


The team applied the treatment to a group of five patients aged 76-88. The patients had previously received surgery to remove non-melanoma skin cancers, leaving them with severe defects in the cartilage of their noses.



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da Vinci Xi Surgical System is ready to flex its arms

da Vinci Xi Surgical System is ready to flex its arms | Longevity science | Scoop.it

While many people no doubt still look at Intuitive Surgical's da Vinci robotic surgical system as a sort of "wonder of the future," it's actually been around now for over 10 years. Therefore, it shouldn't come as a surprise that a new-and-improved model has just been announced. Among other things, the da Vinci Xi Surgical System promises a greater range of motion and more reach than its predecessor.


Like the regular da Vinci, the Xi is designed for performing minimally-invasive surgery. It does so using robotic arms equipped with long skinny surgical instruments, along with an endoscopic camera, that enter the patient's abdomen or chest via relatively small incisions.



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Stretchy, health monitoring skin patch uses off-the-shelf components

Stretchy, health monitoring skin patch uses off-the-shelf components | Longevity science | Scoop.it

A team of engineers at the University of Illinois at Urbana-Champaign and Northwestern University is developing a stick-on patch that makes health monitoring more flexible and practical. Building on previous work, the latest design replaces custom-made components with off-the-shelf, chip-based electronics to deliver a soft, tattoo-like epidermal electronic system for wireless health monitoring.



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Russ Roberts's curator insight, April 10, 11:01 PM

A nice application of surface mount and chip technology for wireless health monitoring.  Since the stick-on medical patch uses "off-the-shelf", chip-based electronics, the cost of this applied technology should be fairly cheap.  Aloha de Russ (KH6JRM).

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Forcing cancer cells to devour themselves by blocking a protein signal | KurzweilAI

Forcing cancer cells to devour themselves by blocking a protein signal | KurzweilAI | Longevity science | Scoop.it

Under stress from chemotherapy or radiation, some cancer cells dodge death by autophagy — eating a bit of themselves — allowing them to essentially sleep through treatment and later awaken as tougher, resistant disease.


But interfering with a single cancer-promoting protein and its receptor can turn this resistance mechanism into lethal, runaway self-cannibalization, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cell Reports (open access).



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Fruits and Vegetables Do More to Reduce Cancer and Extend Life Than Many Prescription Drugs

Fruits and Vegetables Do More to Reduce Cancer and Extend Life Than Many Prescription Drugs | Longevity science | Scoop.it

Those who eat seven or more servings of fruits and vegetables a day cut their risk of death at any age by 42 percent compared to those who don’t get a full serving of the foods.



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Magnetically controlled nanoparticles cause cancer cells to self-destruct | KurzweilAI

Magnetically controlled nanoparticles cause cancer cells to self-destruct | KurzweilAI | Longevity science | Scoop.it

Researchers at Lund University in Sweden have developed a technique to use magnetically controlled nanoparticles to force tumor cells to “self-destruct.” without harming surrounding tissue, as with radiotherapy, and tissues elsewhere in the body, as with chemotherapy.


“Our technique is able to attack only the tumor cells,” said Enming Zhang, first author of the study.


Inducing cell suicide

The technique involves getting the nanoparticles into a tumor cell, where they bind to lysosomes...



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IBM's Watson supercomputer takes aim at brain cancer

IBM's Watson supercomputer takes aim at brain cancer | Longevity science | Scoop.it

IBM's Watson supercomputer is being re-tasked to help clinicians create personalized treatments for a common form of brain cancer known as glioblastoma. The project, which is a collaboration between IBM and the New York Genome Center (NYGC), hopes to make use of Watson's artificial intelligence to analyze vast quantities of data in order to suggest a personalized life-saving treatment based on the patient's individual case.



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MIT’s fast synthesis system could boost peptide-drug development | KurzweilAI

MIT’s fast synthesis system could boost peptide-drug development | KurzweilAI | Longevity science | Scoop.it

Small protein fragments, also called peptides, are promising as drugs because they can be designed for very specific functions inside living cells, but manufacturing the peptides takes several weeks, making it difficult to obtain large quantities, and to rapidly test their effectiveness.


A team of MIT chemists and chemical engineers has designed a way to manufacture peptides in mere hours. The new system, described in a recent issue of the journal ChemBioChem, could have a major impact on peptide drug development, says Bradley Pentelute, an assistant professor of chemistry and leader of the research team.



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U.S. advisers back DNA-based colon cancer test

A colon cancer screening method that analyzes DNA from stool samples won the unanimous backing of a U.S. advisory panel on Thursday, paving the way for potential regulatory approval of the non-invasive test.


A panel of outside experts advising the Food and Drug Administration voted 10-0 to recommend approval of the Cologuard screening test made by Exact Sciences Corp.



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ATHENA "desktop human" for drug and toxic agent screening gets a liver

ATHENA "desktop human" for drug and toxic agent screening gets a liver | Longevity science | Scoop.it

A five-year, US$19 million multi-institutional effort is working on developing a "desktop human" that could reduce the need for animal testing in the development of new drugs. The "homo minitus" is a drug and toxicity analysis system that would comprise four human organ constructs interconnected to mimic the response of human organs. The project has now reported success in the development of its first organ construct, a human liver construct that responds to exposure to a toxic chemical much like a real liver.



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Pasquale Valente's curator insight, March 28, 4:13 AM

the ultimate goal of the project is to, "build a lung that breathes, a heart that pumps, a liver that metabolizes and a kidney that excretes."

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Nasal spray nanovaccine promises no pain, more gain

Nasal spray nanovaccine promises no pain, more gain | Longevity science | Scoop.it

Vaccines save lives, but sometimes they fail to reach the people who need them most, in parts of the developing world. A research team from Iowa State University is currently developing a new generation of vaccines that uses nanotechnology, and is delivered in spray form. One of the advantages of this new type of vaccine is that is can increase access to people living in remote areas because it requires no refrigeration and is simpler to administer.


Current vaccines typically work by introducing part of a virus or bacteria into the body, to trigger what is known as humoral response – the immune system’s ability to produce antibodies that prevent future infections. But more recently, science has started to focus on the use of T cells (white blood cells that monitor abnormalities and infections) to fight viral and bacterial infections, a possibility that these new spray vaccines also explore.



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Finger-prick technique opens door for DIY stem cell donors

Finger-prick technique opens door for DIY stem cell donors | Longevity science | Scoop.it

Harvesting samples for producing stem cells can be rather painful. Techniques can involve collecting large amounts of blood, bone marrow or skin scrapes. The reality is intrusive measures such as these can be very off-putting. But what if it was as simple as a finger-prick? Such a DIY approach, which is so easy it can be done at home or in the field without medical staff, has been developed by researchers at Singapore's A*STAR Institute of Molecular and Cell Biology (IMCB).


Unlike previous techniques that require comparatively large cell samples, the ICMB team has managed to successfully reprogram mature human cells into hiPSCs with high efficiency using less than a single drop of blood.



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Too much animal protein tied to higher diabetes risk

People who eat the most protein, especially from animal sources, are more likely to be diagnosed with type 2 diabetes, according to a study of European adults.

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Spinal stimulation allows paraplegics to move legs

Spinal stimulation allows paraplegics to move legs | Longevity science | Scoop.it

Epidural electrical stimulation involves implanting an electrode array along the lower part of the spinal cord, which ordinarily controls movement of the hips, knees, ankles and toes.


Unlike some similar approaches, the electrodes aren't being used to directly stimulate the muscles. Instead, they act to reengage the spinal cord's local nerve network, which doesn't require input from the brain to carry out basic motor functions.


Researchers surmised that this stimulation, combined with sensory input such as stepping on a treadmill could lead to movement.



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World-first regeneration of a living organ

World-first regeneration of a living organ | Longevity science | Scoop.it

For the first time, the team has successfully regenerated a living organ in mice by manipulating DNA.


The organ in question was the thymus, which is located next to the heart and is an integral part of the immune system. In humans, it achieves most of its growth in early life, continuing to then grow slowly until puberty when it slowly begins to shrink for the remainder of a person's life. It's deterioration with age leaves older people with greater susceptibility to infections, such as flu.



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Get fit now! Early-life cardiovascular problems linked to cognitive deficits later

Get fit now! Early-life cardiovascular problems linked to cognitive deficits later | Longevity science | Scoop.it

Researchers have known for some time that cardiovascular problems in middle and later adulthood may cause cognitive deficits as we age. But surprisingly, there has been little, if any, research into whether high blood pressure, elevated blood glucose and high cholesterol earlier in adulthood have the same effect. A new study by University of California, San Francisco researchers shows that they may, providing another reason to pay attention to fitness and cardiovascular health early in life.



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Scientists regenerate immune organ in mice

British scientists have for the first time used regenerative medicine to fully restore an organ in a living animal, a discovery they say may pave the way for similar techniques to be used in humans in future.


The University of Edinburgh team rebuilt the thymus - an organ central to the immune system and found in front of the heart - of very old mice by reactivating a natural mechanism that gets shut down with age.



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Scientists watch bioengineered self-healing muscle tissue grow within a mouse

Scientists watch bioengineered self-healing muscle tissue grow within a mouse | Longevity science | Scoop.it

The living skeletal muscle tissue grown by Duke University researchers is 10 times stronger than any previously bioengineered muscles. Not only does it contract as strongly and as rapidly as the real thing, but it is also capable of self-healing, both in the lab and after implantation into an animal. This has been proven beyond doubt through a novel approach that involves peeking at the growing muscle tissue through a glass window in the back of a living mouse.



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Gut simulator could bring down the costs of drug development

Gut simulator could bring down the costs of drug development | Longevity science | Scoop.it

Before drugs are tested on humans, they first go through pre-clinical tests on animals. Because humans and animals don't have identical gastrointestinal tracts, however, the way in which the drugs are absorbed by the body often differs between the two. A scientist from the UK's University of Huddersfield hopes to address that discrepancy, with his "gut simulator."



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"Mini hearts" on veins could be used to treat circulatory problems

"Mini hearts" on veins could be used to treat circulatory problems | Longevity science | Scoop.it

When someone has chronic venous insufficiency, it means that because of faulty valves in their leg veins, oxygen-poor blood isn't able to be pumped back to their heart. The George Washington University's Dr. Narine Sarvazyan has created a possible solution, however – a beating "mini heart" that's wrapped around the vein, to help push the blood through.


The mini heart takes the form of a cuff of rhythmically-contracting heart tissue, made by coaxing the patient's own adult stem cells into becoming cardiac cells. When one of those cuffs is placed around a vein, its contractions aid in the unidirectional flow of blood, plus it helps keep the vein from becoming distended. Additionally, because it's grown from the patient's own cells, there's little chance of rejection.



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Netherlands patient gets 3D printed skull in life-saving operation

Netherlands patient gets 3D printed skull in life-saving operation | Longevity science | Scoop.it
A Netherlands patient suffering from a chronic bone disorder got a 3D printed skull after undergoing a life-saving operation. The 22-year-old woman is ailed with a degenerating disorder which has caused her skull to grow thicker, from 1.5 centimeters to 5 centimeters. She also suffered from poor vision and severe headaches. Doctors removed the top part of her skull and replaced it with an implant version made by a 3D printer.



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First comprehensive atlas of human gene activity released | KurzweilAI

First comprehensive atlas of human gene activity released | KurzweilAI | Longevity science | Scoop.it

A large international consortium of researchers has produced the first comprehensive, detailed map of the way genes work across the major cells and tissues of the human body. The findings describe the complex networks that govern gene activity, and the new information could play a crucial role in identifying the genes involved with disease.


“Now, for the first time, we are able to pinpoint the regions of the genome that can be active in a disease and in normal activity, whether it’s in a brain cell, the skin, in blood stem cells or in hair follicles,” said Winston Hide, associate professor of bioinformatics and computational biology at Harvard School of Public Health (HSPH) and one of the core authors of the main paper in Nature.



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Miso: The cure for the so-so

Miso: The cure for the so-so | Longevity science | Scoop.it
Just a dab will get rid of the blahs and make a dish more healthful.


Miso not only delivers flavor but also adds protein and the antioxidants zinc, copper and manganese. Because it is fermented, it aids in digestion and supports the immune system.

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Smart home to detect symptoms of neurodegenerative disease

Smart home to detect symptoms of neurodegenerative disease | Longevity science | Scoop.it

The Tecnalia Centre for Applied Research has created a system of sensors which when fitted in a home can monitor changes in a person's habits and routine. These observations can then be used to assess whether an individual is suffering from the early stages of a neurodegenerative disease such as Alzheimer's.


The aim of the project is to improve the quality of life for elderly patients, by installing these sensors in either the care homes or supervised apartments of the patients. The prototype, which has been in development for three years, is currently installed on the premises of Tecnalia in Zamudio, Bizkaia, Spain.



Ray and Terry's 's insight:

Interesting application for the technology.

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