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Treatment to prevent Alzheimer’s disease moves a step closer | KurzweilAI

A new drug designed to prevent the early stages of Alzheimer’s disease could enter clinical trials in a few years’  time, according to scientists.

Alzheimer’s disease begins when a protein called amyloid-β (Aβ) starts to clump together in senile plaques in the brain, damaging nerve cells and leading to memory loss and confusion.

 

 

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Christina Mediate's comment, February 24, 2013 5:56 PM
Being able to stop the formation of senile plaques makes this drug look promising. Those plaques are what cause the damage to the brain cells and start the initial memory loss. I'm anxious to see how it works on humans though. Right now it's only safe on the mice. But this is a very crucial step towards a possible new treatment or cure for the disease.
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Brain scan can sort dementia by type

Brain scan can sort dementia by type | Longevity science | Scoop.it

Scientists say they have found a way to distinguish between different types of dementia without the need for invasive tests, like a lumbar puncture.

 

US experts could accurately identify Alzheimer's disease and another type of dementia from structural brain patterns on medical scans, Neurology reports.

Currently, doctors can struggle to diagnose dementia, meaning the most appropriate treatment may be delayed.

 

More invasive tests can help, but are unpleasant for the patient.

 

 

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Pacemaker-like device being trialled as Alzheimer's treatment

Pacemaker-like device being trialled as Alzheimer's treatment | Longevity science | Scoop.it
Researchers are investigating the use of pacemaker-like devices for the treatment of Alzheimer’s disease.
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The process of deep brain stimulation involves using a pacemaker-like implanted device to apply controlled mild electrical pulses to specific areas of the brain. In recent studies, it has been used – with some success – to treat conditions such as Parkinson's disease, major depression and Tourette syndrome. Now, in the ADvance Study, researchers at several research centers are exploring its use in restoring memory function to people with Alzheimer’s disease.

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Scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer's / UCLA Newsroom

Earlier this year, researchers identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease.

 

Published in the March 6 issue of the Journal of Alzheimer's Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein.

 

Previous laboratory work by the team demonstrated that specific types of immune cells in Alzheimer's patients may respond to therapy with vitamin D3 and curcumin, a chemical found in turmeric spice, by stimulating the innate immune system to clear amyloid beta. But the researchers didn't know how it worked.

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Brain implant could warn of the onset of dementia

Brain implant could warn of the onset of dementia | Longevity science | Scoop.it

A new moisture-proof sensor has been developed, to monitor cerebral pressure that can lead to dementia. It was created by researchers at the Fraunhofer Institute for Biomedical Engineering IBMT in St. Ingbert in Germany.

 

Scientists don’t know why cerebral pressure suddenly increases in certain people, but they do know that it disrupts blood circulation, leading to parts of the brain dying off as happens in a stroke. The condition is so common that it could be the cause of up to 10 percent of cases of dementia in Europe.

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Exercise may protect the aging brain, a study shows

Exercise may protect the aging brain, a study shows | Longevity science | Scoop.it

A new study suggests that physical activity may mitigate cognitive decline in older adults.

 

Men who were inactive displayed the greatest atrophy (brain shrinkage).

 

Contrary to common understanding, social and intellectual activity did not appear to affect shrinkage according to this study.

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Vitamin E levels linked to cognitive health

Researchers compared vitamin E levels in Alzheimer's, mild cognitive impairment, and cognitively normal subjects.

 

Individuals with cognitive impairment or Alzheimer's had lower blood levels of vitamin E.

 

The study concluded that both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD.

 

 

Neurobiol Aging. 2012 Oct;33(10):2282-90. Epub 2011 Dec 20.
http://www.neurobiologyofaging.org/article/PIIS0197458011004982/abstract

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Three coffees a day keeps dementia away, say researchers

Three coffees a day keeps dementia away, say researchers | Longevity science | Scoop.it

In a recent study, maintaining high blood levels of caffeine appeared to help adults over 65 ward off Alzheimer's disease. The study participants started with mild cognitive impairment, but none of the participants with higher blood levels developed Alzheimer's during the 2-4 year period.

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Drug To Diagnose Alzheimer’s Disease Receives FDA Approval

Drug To Diagnose Alzheimer’s Disease Receives FDA Approval | Longevity science | Scoop.it

This drug detects and quantifies a particular biological marker for Alzheimer’s. There is still no cure, and the drug is radioactive...

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New MRI technique may predict rate of progress and prion-like spread of dementias | KurzweilAI

New MRI technique may predict rate of progress and prion-like spread of dementias | KurzweilAI | Longevity science | Scoop.it

A new technique for analyzing brain images may make it possible to predict the rate of progression and physical path of many degenerative brain diseases, using just one magnetic resonance imaging (MRI) image...

 

The technique also supports mounting evidence that dementias spread through the brain along specific neuronal pathways in the same manner as prion diseases."

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Alzheimer's to triple by 2050 as baby boomers age

The number of U.S. residents aged 65 and older living with Alzheimer's disease is expected to nearly triple to 13.8 million by 2050 as aging baby boomers swell the ranks of those living with the brain-wasting disease, U.S. researchers said on Wednesday.

 

 

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Greg Wurn's comment, February 8, 2013 1:40 PM
one of the reason they are feeding flouride to the population, kill them with cancer before they get Alzhimers
Christina Mediate's comment, February 24, 2013 5:13 PM
I've read that there was hope to have a cure for Alzheimer's by 2025 several times throughout my research. However, this article is saying that the efforts of the Obama Administration to help find this cure, could be unsuccessful due to cutting costs. It's already to late for my grandmother seeing as how she has been living with this disease for about 15 years and is now 86 years old.
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Toxic interaction in neurons that leads to dementia and ALS | KurzweilAI

Toxic interaction in neurons that leads to dementia and ALS | KurzweilAI | Longevity science | Scoop.it
Researchers at Mayo Clinic in Florida have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia.

The findings shed new light on the link between culprits implicated in two devastating neurological diseases: Alzheimer’s disease and amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, which afflicts physicist Stephen Hawking.

There is no cure for frontotemporal dementia, a disorder that affects personality, behavior and language and is second only to Alzheimer’s disease as the most common form of early-onset dementia.
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Johns Hopkins surgeons implant first brain ‘pacemaker’ for Alzheimer’s disease in US | KurzweilAI

Johns Hopkins surgeons implant first brain ‘pacemaker’ for Alzheimer’s disease in US | KurzweilAI | Longevity science | Scoop.it

Researchers at Johns Hopkins Medicine have surgically implanted a pacemaker-like device into the brain of a patient in the early stages of Alzheimer’s disease, the first such operation in the United States.

 

The device, which provides deep brain stimulation and has been used in thousands of people with Parkinson’s disease, is seen as a possible means of boosting memory and reversing cognitive decline.

 

 

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Quick Test Speeds Search for Alzheimer's Drugs: Compound Restores Motor Function and Longevity to Fruit Flies | ZeitNews

Quick Test Speeds Search for Alzheimer's Drugs: Compound Restores Motor Function and Longevity to Fruit Flies | ZeitNews | Longevity science | Scoop.it
An efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease, according to new research that could help...

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New stem-cell-derived cells hold promise for Alzheimer’s, other brain diseases | KurzweilAI

In neurodegenerative diseases, the choroid plexus and CPECs age prematurely, resulting in reduced CSF formation and decreased ability to flush out the plaque-forming proteins that are a hallmark of Alzheimer’s.

 

Transplant studies have provided proof of concept for CPEC-based therapies. However, such therapies have been hindered by the inability to expand or generate CPECs in culture.

 

“Our method is promising, because for the first time we can use stem cells to create large amounts of these epithelial cells, which could be utilized in different ways to treat neurodegenerative diseases,” said Monuki, an associate professor of pathology & laboratory medicine and developmental & cell biology at UCI.

 

 

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Carbs Fog Aging Brains - Vital Choice

Carbs Fog Aging Brains - Vital Choice | Longevity science | Scoop.it

Mayo Clinic study in seniors finds that diets high in sugars and starches promote brain fog and dementia.

 

Correlations between carb intake and brain fog included:

*Those with the highest carbohydrate intake relative to total fat and protein intake were 3.6 times likelier to develop MCI.

 

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Dental health linked to dementia risk: study

People who keep their teeth and gums healthy with regular brushing may have a lower risk of developing dementia later in life, according to a U.S. study.

 

Researchers at the University of California who followed nearly 5,500 elderly people over an 18-year-period found that those who reported brushing their teeth less than once a day were up to 65 percent more likely to develop dementia than those who brushed daily.

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Deep brain stimulation may hold promise for mild Azheimer’s disease | KurzweilAI

Deep brain stimulation may hold promise for mild Azheimer’s disease | KurzweilAI | Longevity science | Scoop.it
A study at the University of Toronto on a handful of people with suspected mild Alzheimer’s disease (AD) suggests that a device that sends continuous electrical impulses to specific “memory” regions of the brain appears to increase neuronal activity.

 

Results of the study using deep brain stimulation, a therapy already used in some patients with Parkinson’s disease and depression, may offer hope for at least some with AD, an intractable disease with no cure.
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Berries can keep your brain sharp

Berries can keep your brain sharp | Longevity science | Scoop.it

A new long term berry study found that just a couple of servings a week could delay memory decline...

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How vitamin D may help clear amyloid plaques found in Alzheimer’s | KurzweilAI

How vitamin D may help clear amyloid plaques found in Alzheimer’s | KurzweilAI | Longevity science | Scoop.it
UCLA researchers have identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main...
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