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Longevity science
Live longer in good health and you will have a chance to extend your healthy life even further
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Correcting faulty DNA: stronger bodies, smarter minds, longer lives

Correcting faulty DNA: stronger bodies, smarter minds, longer lives | Longevity science | Scoop.it
What if you could improve your memory, become smarter and stronger, and live in an ageless disease-free body – just by taking a pill?

 

Though this may sound like the stuff of science fiction, experts are developing a better understanding of our genetic mysteries, including the powerful influence that DNA wields on our lives. It's becoming clear that cancer, heart disease, diabetes, obesity; most mental disorders, and many other ailments, could all be the result of a clash between genes we inherited from our past, and today's modern environment.

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Revved-Up Protein Fights Aging - ScienceNOW

Revved-Up Protein Fights Aging - ScienceNOW | Longevity science | Scoop.it
An unlikely, decadelong journey that began with the discovery of a rapidly aging mouse has led scientists to a protein that seems to protect animals from cancer and other scourges of old age—with no apparent downsides. There are still lots of mysteries about the protein, called BubR1, but the work offers clues about how protecting chromosomes can enhance health.
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New technique replaces diseased DNA, but would give kids two mothers

New technique replaces diseased DNA, but would give kids two mothers | Longevity science | Scoop.it

Scientists hope to prevent mitochondrial disease by removing chromosomes from the eggs of affected women, and putting them into donor eggs.

 

Any children that would be born would not carry the mother’s mitochondrial mutations – but would have the mitochondrial DNA from the woman who donated her eggs.

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Solid Tumors, Chromosome Abnormalities and Genes involved in Cancer

Solid Tumors, Chromosome Abnormalities and Genes involved in Cancer | Longevity science | Scoop.it

Solid Tumors, Chromosome Abnormalities and Genes involved in Cancer reviewed and published in the Atlas of Genetics and Cytogenetics in Oncology and Haematology...


Via Brian Shields
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Caloric restriction has a protective effect on chromosomes

Caloric restriction has a protective effect on chromosomes | Longevity science | Scoop.it

According to a study carried out by a team led by María Blasco, the director of the Spanish National Cancer Research Centre (CNIO) and head of the Telomeres and Telomerase Group, a sustained lowering of food intake over time results in an increase of telomere length -- the ends of chromosomes -- in adult mice, which has a protective effect on the DNA and genetic material.

 

 

Ray and Terry's 's insight:

Caloric restriction is step 6 of the Transcend program. Moderate CR (10%) is manageable and easier to sustain over the long term.

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Blocking Telomerase Kills Cancer Cells but Provokes Resistance, Progression | MD Anderson Cancer Center

Inhibiting telomerase, an enzyme that rescues malignant cells from destruction by extending the protective caps on the ends of chromosomes, kills tumor cells but also triggers resistance pathways that allow cancer to survive and spread, scientists reported.

 

"Telomerase is overexpressed in many advanced cancers, but assessing its potential as a therapeutic target requires us to understand what it does and how it does it," said senior author Ronald DePinho, M.D., president of The University of Texas MD Anderson Cancer Center.

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Cancers Delete Suppressing Genes on Chromosomes - Softpedia

Cancers Delete Suppressing Genes on Chromosomes - Softpedia | Longevity science | Scoop.it

Numerous cancer types are known to have an influence on human chromosomes, deleting certain portions in order to be able to infect the body. Now, researchers have shown that some of these deleted sections contain clusters of tumor-suppressing genes.

 

Experts say that this has been suspected for quite some time, but that evidence to prove that this was indeed the case has been lacking. The new investigation looked at a copy-number alteration (CNA), a deletion that occurs on the short arm of chromosome 8 (8p).

 

The study was carried out on mouse models of human liver cancer. Researchers found that this specific CNA affected a series of genes that work together to counteract tumors as soon as they start evolving.

 

 

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