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Yale study links common chemicals to osteoarthritis

Yale study links common chemicals to osteoarthritis | Longevity science | Scoop.it

A new study just published in Environmental Health Perspectives, is the first to look at the associations between perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and osteoarthritis. This is a potentially huge discovery because these chemicals, (when referred to together, known as PFCs) are widespread in the environment and known to contaminate humans and wildlife. PFCs are used in more than 200 industrial processes and consumer products including grease-proof paper food containers, stain and water-resistant fabrics and personal care products.

"We found that PFOA and PFOS exposures are associated with higher prevalence of osteoarthritis, particularly in women, a group that is disproportionately impacted by this chronic disease," Sarah Uhl, who authored the study along with Yale Professor Michelle L. Bell and Tamarra James-Todd, an epidemiologist at the Harvard Medical School and Brigham and Women's Hospital, said in a press statement.

 

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Pharmacological influence on processes of adjuvant arthritis: Effect of the combination of an antioxidant active substance with methotrexate

A new animal study indicates that carnosine helped mediate rheumatoid arthritis effects. Oxidative stress plays an integral part in arthritis. Carnosine and other antioxidant compounds can help ameliorate the symptoms through their free radical scavenging activity.

 

The study found:

Thus we can conclude that oxidative stress plays an important role in AA and could be controlled by suitable combination therapy of MTX and an antioxidant substance, as demonstrated for carnosine.

 

Reference:

Interdiscip Toxicol. 2012 June; 5(2): 84–91. Published online 2012 June. doi: 10.2478/v10102-012-0015-4

PMCID: PMC3485659

Pharmacological influence on processes of adjuvant arthritis: Effect of the combination of an antioxidant active substance with methotrexate

Frantisek Drafi,1 Katarina Bauerova,1 Viera Kuncirova,1 Silvester Ponist,1 Danica Mihalova,1 Tatiana Fedorova,2 Juraj Harmatha,3 and Radomir Nosal1

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New technique holds promise for treatment of rheumatoid arthritis

New technique holds promise for treatment of rheumatoid arthritis | Longevity science | Scoop.it

A team of scientists at Boston's Dana-Farber Cancer Institute has developed a new technique to treat autoimmune diseases such as rheumatoid arthritis. The approach, which is based on the infusion of cells that regulate immune responses, has been demonstrated to to be effective in mice, even weeks after the disease was initiated.

 

 

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