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Swara Yog - Ancient science of Breathing

Swara Yog - Ancient science of Breathing | LOCAL HEALTH TRADITIONS | Scoop.it

Introduction to swara yog. Good introduction to the system of using breathing for improving health.

 

The correct word is YOG [not yoga, and incorrectly pronounced as Yogaaaaa!]

 

One of the twenty therapies in Ayurved is 'Sound Therapy.' Right kind of sound has healing property. [Noise can make you ill]

 

 At a higher level, there is a method of meditation called Vipasana. Worth trying.

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LOCAL HEALTH TRADITIONS
Local health wisdom ensured our health before modern science arrived. Let us all rediscover and revitalize local health traditions.
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Dr. Matthias Rath - Movement of Life (Warsaw.Poland June/18/2011) - [HD]

Dr. Rath was born in Stuttgart, Germany, in 1955. After graduating from medical school he worked as a physician and researcher at the University Clinic of Ha...
Arun Shrivastava's insight:

This is a memorable speech by Dr. Rath. If you value your life and liberty, ensure that you have seen all the segments of this 56 minute video.

 

He explains the lies and deceptions of the cartel that controls the planet.

Also note that these cartels have the backing of Rothschild and Rockefeller banking cartels. 

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Jasola gets country’s first All India Institute of Ayurveda

Jasola gets country’s first All India Institute of Ayurveda | LOCAL HEALTH TRADITIONS | Scoop.it
It would be the first referral-cum-teaching facility
Arun Shrivastava's insight:

STRENGTHENING LOCAL HEALTH TRADITIONS AND SYSTEMS OF MEDICINES. In India four dominant systems are currently practiced: Ayurved, Yog, Naturopathy and Siddh. Unani evolved when Islam came here. Funnily Yunan means Greece. Muslim doctors prefer to call their system Unani for a reason which is essentially political.  Homeopathy came from Germany. It is time that Ayurved is restored to its pre-eminent position. The new facility can handle complex surgical cases. I am sure this hospital will be popular with women, particularly pregnant women because Ayurved has a holistic system of managing pregnancy, child birth and post natal care.

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Raw Milk Reality: Is Raw Milk Worth the Risk?

Raw Milk Reality: Is Raw Milk Worth the Risk? | LOCAL HEALTH TRADITIONS | Scoop.it
Is raw milk worth the risk for you and your family? In this article, I present a framework for making this decision and provide two alternatives to raw milk.
Arun Shrivastava's insight:

Encourage children to engage with nature, animals, garden and forests. Teach them to milk cows, it boosts their immune system. About raw milk: most of us in my age group have grown up on raw milk [packaged milk was introduced perhaps in the late 1970s]. All we did was buy raw milk from milkman and boiled it once, just once.

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Study: Ultra-Low Doses Of THC May Help Protect Against Neurodegenerative Diseases

There is a great deal of evidence suggesting that cannabis could be beneficial for the prevention and treatment of neurodegenerative diseases like  &h...
Arun Shrivastava's insight:

POPPY SEEDS AND CANNABIS=============================

Frankly, I don't know this Medical Jane but the information gels with my experience.. In South Asia poppy seeds is eaten almost on a daily basis. It is food. Same way we use cannabis for food, oil, fibre, medicines. THC comes from cannabis and can/do prevent neurodegenerative diseases and also reverse cancers. Ultra low doses are ALSO GIVEN IN AYURVED AND HOMEOPATHY. This is no new discovery. It is simply claiming that there is a "discovery." Like India was discovered by Vasco de Gama and USA was discovered by Columbus.

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Garlic Cures 100% of Warts In Clinical Study

Garlic Cures 100% of Warts In Clinical Study | LOCAL HEALTH TRADITIONS | Scoop.it
In the first study of its kind, this common herb was found to have remarkable healing results for common warts and corns.
Arun Shrivastava's insight:

Garlic has been used for treating many medical conditions in Ayurved. Those claims are being validated now.

Study details here: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2004.02348.x/abstract

 

Treatment of corn can be facilitated by using corn cap with crushed garlic. Or, rubbing the corn/wart with crushed garlic.

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Cows chomping on fresh grass and red clover silage produce omega milk

Cows chomping on fresh grass and red clover silage produce omega milk | LOCAL HEALTH TRADITIONS | Scoop.it
Fat is an important ingredient that has a material impact on the nutritional value, texture, taste, shelf-life and producer price of milk. However, milk products are a significant source of saturated fatty acids in the Western diet. How should dairy cattle be fed for their milk to contain more unsaturated ...
Arun Shrivastava's insight:

QUALITY OF MILK DEPENDS UPON WHAT THEY CHOMP

 

Cows grazing on fresh grass red clover produce omega milk. That's not the only thing they chomp. A good grassland/pasture also grows many medicinal plants [some call them weeds] and these add to the natural nutritive content of milk. It is for this reason that China and India had a tradition of maintaining pastures near every village as common pool resources. Unfortunately this has given way to stall feeding which is expensive and also adversely affects nutrition in milk and general animal health.

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PaulingTherapy.com - Reversing Heart Disease w/o Drugs is Possible

PaulingTherapy.com - Reversing Heart Disease w/o Drugs is Possible | LOCAL HEALTH TRADITIONS | Scoop.it
Linus Pauling Heart Therapy
Arun Shrivastava's insight:

THIS IS PAULING'S WEBSITE UP SINCE 1992 AND UPDATED

 

I'd like to draw your attention to three patents that Pauling and Rath filed:

Pauling/Rath Patents

5,278,189 - Prevention and Treatment of Cardiovascular Disease with Ascorbate and Substances that Inhibit the Binding of Lipoprotein(a)

 

5,230,996 - Use of Ascorbate and (Lysine) for Organ and Blood Vessel Treatment Prior to Transplantation.

 

5,650,418 - Therapeutic Lysine Salt Composition and Method of Use

 

Download the documents and see for yourself the thoroughness of their work.

 

Why Don't Doctors Know?

"Most people haven't heard about this because there have been no published studies. (No one goes to jail when a cure for a major disease is not evaluated by science.) The Pauling-therapy for heart disease works quickly. Patients have consistently reported symptom relief in ten days or less, even in advanced disease. The effect is rapid and undeniable, thus the reasons that most people haven't heard about this are not based on science, rather malfeasance." [From the same page]

 

Why  don't Doctors bother?

MONEY, HONEY.

 

 

 

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The Man Who Turned Down Chemotherapy and Outlived His Doctors | Wake Up World

The Man Who Turned Down Chemotherapy and Outlived His Doctors | Wake Up World | LOCAL HEALTH TRADITIONS | Scoop.it
You could say that Stamatis Moraitis forgot to die. Diagnosed by American doctors with lung cancer in 1976, he was given 6 months to live and encouraged to
Arun Shrivastava's insight:

FRIENDS, FAMILY, FRESH VEGETABLES, AND FAITH

 

You can outlive your doctors who try to treat you for cancer. This is the story of Stamatis Moraitis. Given six months to live in 1976, he lived to 102. All his doctors were dead when he returned to America.

 

If you have the MORAITIS INFECTION, you will live longer than your doctors.

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Science Proves Hugging Trees Is Good for Health

Science Proves Hugging Trees Is Good for Health | LOCAL HEALTH TRADITIONS | Scoop.it
It has now been confirmed by science that hugging trees can beneficially affect human health by altering vibrational frequency.
Arun Shrivastava's insight:

WANNA STAY HEALTHY? HUG A TREE.

 

Mathew Silverstone in his book "Blinded by Science" says hugging – or even just being in the vicinity of – a tree can boost one’s health in several ways."

 

Nature's vibrations are unique. There are many scientific studies as well as esoteric ones [like the SECRET LIFE OF PLANTS by Peter Tompkins and Christopher Bird]. Decades of scientific work has gone to understand the plant world. Some have even concluded that "plants may be the bridesmaid at a marriage of physics and metaphysics."

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Cops Switching In Droves From Being Drug WAR CRIMINALS & PROFITEERS To Legalization Entrepreneurs! - YouTube

FIGHTER TO CANNABIS June 20, 2014 Al Jazeera News http://MOXNews.com ONE TIME ONLY DONATION https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=MHT8PM5BPSVC8 $1...

Arun Shrivastava's insight:

FROM CANNABIS FIGHTERS TO CANNABIS FACILITATORS

 

US law enforcement officers are changing their profession. DEFENDING CANNABIS, HELPING GROWERS, FACILITATING GROWTH.

 

What we are witnessing is some sort of awakening.

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Marijuana May Heal Health Problems That Come With Old Age: How Can People Living in Senior Homes Get It? - The Truth

Marijuana May Heal Health Problems That Come With Old Age: How Can People Living in Senior Homes Get It? - The Truth | LOCAL HEALTH TRADITIONS | Scoop.it
Photo Credit: ChameleonsEye / Shutterstock.com May 2, 2014  |   Sue Taylor, a retired Catholic school principal and grandmother from Oakland, California, was living in Atlanta, Georgia writing a parenting handbook when she got a phone call from her son that would disrupt her life. “He told me, ‘Mom, I know how you can open up your metaphysical holistic center,’ which…
Arun Shrivastava's insight:

MARIJUANA FOR THE ELDERLY

 

It heals. I have no doubt in my mind that this the God's own plant sent to earth to heal. On this very blog, I had posted a story of a 125  year old lady from Odisha who credited regular marijuana smoking to her longevity. That story is circulating:

http://beforeitsnews.com/health/2011/08/125-year-old-pot-smoker-claims-weed-was-her-secret-to-longevity-957324.html

 

I have received a few emails in the past telling me that I am promoting drugs. I am not. Never ever smoked pot or used hard drugs even when these things were common in college campus. I have done my research thoroughly. Hence I have no fear in recommending that cannabis heals. Cannabis can be administered in many ways.

 

As milk, it's most nutritious. As food, sweets, bakery products. In India, it's a common food just as opium poppy seeds. As an intoxicant, it does get you high but it also heals unlike cigarette.

 

AN IMPORTANT COMMENT FROM A FRIEND:

RemoveSilvija Bezprezimena You don't have to smoke it. Make oil out of it. It is very simple - cut fresh cannabis bud and put them in a glass jar, add your favorite quality cooking oil, put in sun for several weeks, strain greens out and use the oil as food. Or make a tincture - fill a glass jar with cannabis and pour 100 proof vodka over it or grain alcohol (vodka is most suitable in extracting the active ingredients of all common alcohol types, also grain alcohol) Pour vodka over the jar full of cannabis buds, close jar, shake once a day, let sit for 4-6 weeks. Use the vodka tincture sparingly, as needed. Or even simpler: make a very hot tea and drop a cannabis bud in there. The heat of the tea will activate the THC. Drink tea, eat the green bud in the tea. You don't have to smoke it - try one of the above. Tea is the simplest way and requires no preparation.
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Negative ION Generator (Air Aionizer) - YouTube

Contact: Narayan Das Jethwani, mobile: 0091 092323 55432 Email: sindhisss@yahoo.co.in patent pending Technology license for manufacturing through, "National ...
Arun Shrivastava's insight:

NEGATIVE ION GENERATOR

 

This should be part of our furniture. The video demonstration of how air ionizer cleans air is shown in a simple and [I think] very effective way. Jethwani [a Delhi resident] lights up four incense sticks, places them by the ionizer and covers both with a jar. He then switches on the generator and one can see how smoke is cleared away within minutes. An important parameter when selecting an ionizer is its Clean Air Delivery Rate [CADR]. Many manufacturers make dubious claims.

 

HEALTH BENEFITS

 

There are many authoritative articles on health benefits of ionized air. A short review is given here:

http://nutritionreview.org/2013/04/positive-health-benefits-negative-ions/

Since our city air is polluted and certain pollutants do cause DNA damage, it is advised that homes install ionizer. Particularly the bed room should be ionized before going to sleep. Excellent preventive solution for infants and growing children in the cities.

 

PRICE

 

A good equipment costs about Rs 5000 [roughly 100 dollars], the best models cost close to Rs 10,000.

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Can Chinese Herbal Medicine Treat Cancer? The Research Says Yes

Can Chinese Herbal Medicine Treat Cancer? The Research Says Yes | LOCAL HEALTH TRADITIONS | Scoop.it
Chinese herbal medicine does indeed treat cancer and overwhelmingly results in the improvement or relief of symptoms as well as longer survival rates and reduced metastases.
Arun Shrivastava's insight:
Traditional Chinese Medicine [TCM] like Indian System of Medicine [ISM], is returning. The research study jointly carried out by Chinese and Australian scientists reviewed past publications and found that herbal therapy for cancers works. This is good news for the millions of cancer patients.
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HowStuffWorks "Getting Rid of Cockroaches"

HowStuffWorks "Getting Rid of Cockroaches" | LOCAL HEALTH TRADITIONS | Scoop.it
Cockroaches are creepy, but they're also very complex creatures. Learn about the anatomy of cockroaches and how to get rid of them.
Arun Shrivastava's insight:

I use bay leaf as cockroach repellent. It's natural and safe and it does work. Find out why it works in this short article.

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A Gentle Vaccine Detox For Children - LivingWhole.org

A Gentle Vaccine Detox For Children - LivingWhole.org | LOCAL HEALTH TRADITIONS | Scoop.it
I already know I’m going to catch flack…from those who believe vaccines are perfectly safe, that injecting 49 doses of 16 vaccines containing neurotoxins, carcinogens, antibiotics, detergents, foreign DNA and live and mutated viruses before age six is no cause for concern, and from those who think natural medicine (which has been around since circa day one) and the belief …
Arun Shrivastava's insight:

I AM TRULY AMAZED. As kids we were encouraged to eat Amla [for concentrated Vit C and a daily dose of massage and cilantro. And many other things said here. It works.

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2014 Ebola Outbreak - Information, updates and Homoeopathy | Homeo Book

2014 Ebola Outbreak - Information, updates and Homoeopathy | Homeo Book | LOCAL HEALTH TRADITIONS | Scoop.it
Ebola hemorrhagic fever is a Viral Hemorrhagic Fever - It is a severe, often fatal disease in humans and nonhumans
Arun Shrivastava's insight:

THIS SHORT ARTICLE SHOWS HOMEOPATHIC CURES FOR EBOLA. Keep it handy.

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Cannabis Cultivation 101: How To Start Growing From Seed, From Clone

Cannabis Cultivation 101: How To Start Growing From Seed, From Clone | LOCAL HEALTH TRADITIONS | Scoop.it
Welcome back again to this series aimed at delivering what medicinal growers seeking to grow medicinal cannabis need to know to get started, and impro...
Arun Shrivastava's insight:

THIS IS FOR PREPPIES. CANNABIS 101. People are joining the cannabis bandwagon. It's like oil and gas. That's why the PTBs have kept cannabis "ILLEGAL WORLDWIDE". If cannabis is legalised, we can do away with 99% of pharmaceutical products. If cannabis is legalised we can e4nsure longevity which folks like Cleopatra and Elizabeth Taylor desperately wanted. Why, I don't know. In India Cannabis grows everywhere, so I don't need this C-101. Anyway, go ahead and send me your comments.

 

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Natural Patterns of Sleep | Healthy Sleep

Natural Patterns of Sleep | Healthy Sleep | LOCAL HEALTH TRADITIONS | Scoop.it
Arun Shrivastava's insight:

WHAT IS HEALTHY SLEEP?

Many friends practicing alternative and integrative medicine often ask their patients: Do you sleep well? [followed by do you eat well? Do you have constipation? and generally about diet] During an important exchange between doctor friends in the USA, I was again reminded of "healthy sleep". They also mentioned that as many as 90% of their patients have mild to acute sleep disorder.

This is a serious issue. The article explains four stages of sleep and what everyone needs is N3 and N4 stages. N4 is also called 'deep' or 'slow-wave''.

Power-nap [short 15-18 minute] is also good for health. One of the Yog Aasan is called "Shav-aasan" in which the body is in deep rest [almost akin to a dead body; the Sanskrit word SHAV means dead body]


It's a very informative article. from Harvard Medical School.

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Major study documents nutritional and food safety benefits of organic farming

Major study documents nutritional and food safety benefits of organic farming | LOCAL HEALTH TRADITIONS | Scoop.it
The largest study of its kind has found that organic foods and crops have a suite of advantages over their conventional counterparts, including more antioxidants and fewer, less frequent pesticide residues.
Arun Shrivastava's insight:

NEWCASTLE UNIVERSITY STUDY

 

This is an analysis of 343 different studies on different crops [vegetables, fruits, cereals and foods made from them. The produce from organically managed farms had significantly more nutrition and less toxins. This is not the first time that such incontrovertible evidences have been presented demonstrating overall nutritional superiority of organic foods. However, similar review of Indian crops is now overdue.

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The Movement of Life-Imagine the transformational possibilities

The Movement of Life-Imagine the transformational possibilities | LOCAL HEALTH TRADITIONS | Scoop.it
This website encourages young people to use the available knowledge from these breakthrough technologies to create hands-on pilot projects wherever they live, anywhere in the world. Through the videos on our site, we provide the tools for sharing the experiences from these pilot projects with the goal of liberating the world from the tyranny of control by multinational corporations in the areas of health, food, water, energy, knowledge and work.
Arun Shrivastava's insight:

INSTRUCTIONAL VIDEO FROM DR. MATHIAS RATH'S FOUNDATION

 

As you can see on this page, the first entry [it is pinned as star] is the eight part discussion of Movement of Life by Dr Rath. In this video Dr Rath explains what actually is cardio-vascular disease [CVD]. A lot of doctors confuse you with the cholesterol issue. Malcolm Kendrick, author of the book “The Great Cholesterol Con”, explains the false cholesterol paradigm.

 

To understand the effectiveness of nutrition based solution, it is absolutely essentially to grasp the basic facts about the nature of CVD. Dr Pauling and Dr Rath found that Vitamin C combined with specific sets of nutritional supplements effectively reverses and eliminates any chance of CVD.

 

More detailed information on CVD from Dr Rath is available in PDF format: http://orthomolecular.org/library/jom/1991/pdf/1991-v06n03&04-p125.pdf

 

References to large scale clinical trials and results are briefly discussed here: http://orthomolecular.org/resources/omns/v01n02.shtml

 

Article of general nature but specific to Orthomolecular approach to treatment of CVD is here: http://www.selfgrowth.com/articles/orthomolecular-treatment-for-heart-disease

 

Since CVD is affecting many people, please circulate these articles, and videos as widely as possible. These are in the public domain. There are certain books which are NOT in the public domain but I have them. You can request for a copy and I shall send it you.  

 

 

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Meet the Tiniest Dairy Cow in the World! Vechur Cattle – A...

Meet the Tiniest Dairy Cow in the World! Vechur Cattle – A... | LOCAL HEALTH TRADITIONS | Scoop.it
Print PDFBy Patrice Lopatin Vechur cattle originated in the area around the village of Vechur in the southwest state of Kerala, India. The tiny gentle cows were so greatly valued that at one time wellwishers presented them as wedding gifts. These native cattle have been rescued from the brink of...
Arun Shrivastava's insight:
Cattle diversity of India is truly astounding. This article is about Vechur breed of cows, smallest in the world. It gives about 3-4 quarts of milk every day and requires just 1/4 acre of grazing land. The milk has about 5% of butter-fat making it [perhaps] the most nutritious. This milk is considered to have extraordinary medicinal properties and there has been some research claiming that the milk from such cattle helps lower the risk of many chronic conditions such as diabetes, asthma, autism, allergies, schizophrenia, SIDS, and cardiac disease.
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Cops Contradict Holder: Legalizing Drugs Will Save Lives - YouTube

Neill Franklin, a former Maryland narcotics cop, and Sean Dunagan, a former DEA analyst, take issue with U.S. Attorney General Eric Holder's claim that legal...
Arun Shrivastava's insight:

COPS SAY LEGALIZE DRUGS DOT COM

www.CopsSayLegalizeDrugs.com

AND

LAW ENFORCEMENT AGAINST PROHIBITION

http://www.leap.cc/

Enjoy a smoke guys!!!!!!

 

 

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Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes

Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes | LOCAL HEALTH TRADITIONS | Scoop.it
Arun Shrivastava's insight:

A REASONABLY GOOD STUDY

 

The study lists 17 commonly found herbs that are used in the treatment of diabetes. It has been known for some time, perhaps three decades, that diabetes, CVD, cancers and other degenerative diseases are induced by oxidative damage. Hence, anti-oxidants became a rage. However, most of the anti-oxidants can be derived from raw food.

And diabetes can be cured by raw food diet. There are some claims of one month cure [NOT SURE]. The question is: why raw food is healthiest? My personal experience is that ever since hydrogenated/processed oils were introduced, with plenty of false promises of D2 and then "cholesterol reducing properties", the issue became complicated and misled the masses.

 

Raw food, or steamed food, therefore, is best. Cooked food in any oil is bad for the diabetic. Any oil oxidises when exposed to heat. Reuse of once heated oil, as is normal in many households, is a KILLER. 

 

A powerful combination of raw food, D3 [Cholecalciferol], Lipospheric Vitamin C, CoQ10, and Glutathione, AND 3 TO 4 LITRES OF CLEAN WATER PER DAY [NOT BOTTLED WATER], alkalizing blood pH level [baking soda], EARTHING, breathing ionized air, IBT [Inclined Bed Therapy] should cure most degenerative diseases without depending upon the corporate system of draining your wealth and health.  

 

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Small Farmers Are Feeding The World on Less Land

Small Farmers Are Feeding The World on Less Land | LOCAL HEALTH TRADITIONS | Scoop.it

Small-scale farmers are producing the majority of the world's food on just 25% of farmland. GRAIN report says small farms are more productive than large scale industrial monocultures.

 

– in Belarus, on 17% of the land, small farmers are producing 87.5% of fruit and berries, 82% of potatoes, 80% vegetables and 32% of eggs

 

– in Kenya, with just 37% of the country's farmland, small farms produce 73% of the agricultural output

 

– in El Savador, small farmers manage 29% of the land and yet produce 90% of the country's beans, 84% maize and 51% pork.

 

These are just a few examples showing how important these small farms are to each country.


Via Sepp Hasslberger
Arun Shrivastava's insight:

SMALL FARMS AND INTELLIGENT FARMERS

 

That's what is required to feed the world, not GMOs, not fertilizers or pesticides. Russia was driven to starvation level during early 1990s, Families took to growing food in their backyards. Today most of its fruits and veggies still come from small farms.

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Sepp Hasslberger's curator insight, June 8, 11:44 AM

So much for "we need GMOs to feed the world". 

What we need is more small farmers working in the traditional way, rather than genetically modified crops that occupy a lot of farmland, need a lot of poison sprays, and produce food that can hardly be called that.

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Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations

Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations | LOCAL HEALTH TRADITIONS | Scoop.it
Arun Shrivastava's insight:

D3 DEFICIENCY AND OBESITY

There are at least 3000 articles on Vitamin D3 deficiency and obesity.

 

It's a good idea to combine diet with optimum dosing of D3. Once again I remind particularly those living in the UK that D2 is called ERGOCALCIFEROL and is [perhaps] not even 5% as effective as D3 which is called CHOLECALCIFEROL. The minimum maintenance dosage should be 80 International Units X body weight in kilograms.

 

If calcium supplementation is required, it must be combined with magnesium [1 part of magnesium to 2 parts calcium]

 

BUT, your doctor will NEVER tell you.

 

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Three important studies on CoQ10

Three important studies on CoQ10 | LOCAL HEALTH TRADITIONS | Scoop.it
Arun Shrivastava's insight:

THREE IMPORTANT STUDIES ON CoQ10

 

1. IUBMB Life. 2011 Jan;63(1):42-8. doi: 10.1002/iub.413.

Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans.

Schmelzer C1, Niklowitz P, Okun JG, Haas D, Menke T, Döring F.

Author information 1Department of Molecular Prevention, Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Heinrich-Hecht-Platz 10, Kiel, Germany. sek@molprev.uni-kiel.deAbstract

Studies in vitro and in mice indicate a role for Coenzyme Q(10) (CoQ(10) ) in gene expression. To determine this function in relationship to physiological readouts, a 2-week supplementation study with the reduced form of CoQ(10) (ubiquinol, Q(10) H(2) , 150 mg/d) was performed in 53 healthy males. Mean CoQ(10) plasma levels increased 4.8-fold after supplementation. Transcriptomic and bioinformatic approaches identified a gene-gene interaction network in CD14-positive monocytes, which functions in inflammation, cell differentiation, and peroxisome proliferator-activated receptor-signaling. These Q(10) H(2) -induced gene expression signatures were also described previously in liver tissues of SAMP1 mice. Biochemical and NMR-based analyses showed a reduction of low density lipoprotein (LDL) cholesterol plasma levels after Q(10) H(2) supplementation. This effect was especially pronounced in atherogenic small dense LDL particles (19-21 nm, 1.045 g/L). In agreement with gene expression signatures, Q(10) H(2) reduces the number of erythrocytes but increases the concentration of reticulocytes.

 

In conclusion, Q(10) H(2) induces characteristic gene expression patterns, which are translated into reduced LDL cholesterol levels and altered parameters of erythropoiesis in humans.

Copyright © 2011 Wiley Periodicals, Inc.

 

2. Atherosclerosis. 2012 Apr;221(2):311-6. doi: 10.1016/j.atherosclerosis.2011.10.027. Epub 2011 Oct 25.

 Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials.Author information

Gao L1, Mao Q, Cao J, Wang Y, Zhou X, Fan L.

1Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.

AbstractOBJECTIVE:

The purpose of this study was to quantify the effect of coenzyme Q10 on arterial endothelial function in patients with and without established cardiovascular disease.

BACKGROUND:

Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis.

METHODS AND RESULTS:

The search included MEDLINE, Cochrane Library, Scopus, and EMBASE to identify studies up to 1 July 2011. Eligible studies were randomized controlled trials on the effects of coenzyme Q10 compared with placebo on endothelial function. Two reviewers extracted data on study characteristics, methods, and outcomes. Five eligible trials enrolled a total of 194 patients. Meta-analysis using random-effects model showed treatment with coenzyme Q10 significantly improvement in endothelial function assessed peripherally by flow-mediated dilatation (SMD 1.70, 95% CI: 1.00-2.4, p<0.0001). However, the endothelial function assessed peripherally by nitrate-mediated arterial dilatation was not significantly improved by using fix-effects model (SMD -0.19, 95% CI: -1.75 to 1.38, p = 0.81).

CONCLUSION:

Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID: 22088605 [PubMed - indexed for MEDLINE]

 

 

3. Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects.

2012 Apr;34(2):389-403. doi: 10.1007/s11357-011-9229-1. Epub 2011 Mar 15.Author information

Gutierrez-Mariscal FM1, Perez-Martinez P, Delgado-Lista J, Yubero-Serrano EM, Camargo A, Delgado-Casado N, Cruz-Teno C, Santos-Gonzalez M, Rodriguez-Cantalejo F, Castaño JP, Villalba-Montoro JM, Fuentes F, Perez-Jimenez F, Lopez-Miranda J.

1Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, Spain.

 Abstract

Coenzyme Q10 (CoQ) is a powerful antioxidant that reduces oxidative stress. We explored whether the quality of dietary fat alters postprandial oxidative DNA damage and whether supplementation with CoQ improves antioxidant capacity by modifying the activation/stabilization of p53 in elderly subjects. In this crossover study, 20 subjects were randomly assigned to receive three isocaloric diets during 4 weeks each: (1) Mediterranean diet (Med diet), (2) Mediterranean diet supplemented with CoQ (Med+CoQ diet), and (3) saturated fatty acid-rich diet (SFA diet). Levels of mRNAs were determined for p53, p21, p53R2, and mdm2. Protein levels of p53, phosphorylated p53 (Ser20), and monoubiquitinated p53 were also measured, both in cytoplasm and nucleus. The extent of DNA damage was measured as plasma 8-OHdG. SFA diet displayed higher postprandial 8-OHdG concentrations, p53 mRNA and monoubiquitinated p53, and lower postprandial Mdm2 mRNA levels compared with Med and Med+CoQ diets (p < 0.05). Moreover, Med+CoQ diet induced a postprandial decrease of cytoplasmatic p53, nuclear p-p53 (Ser20), and nuclear and cytoplasmatic monoubiquitinated p53 protein (p < 0.05). In conclusion, Med+CoQ diet improves oxidative DNA damage in elderly subjects and reduces processes of cellular oxidation. Our results suggest a starting point for the prevention of oxidative processes associated with aging.

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