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A topic to discuss everything about science. The title is a reference to the book wrote by Douglas Adams.
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How PowerPoint Is Ruining Higher Ed, Explained in One PowerPoint

How PowerPoint Is Ruining Higher Ed, Explained in One PowerPoint | "Life, the Universe and Everything" else in Science | Scoop.it
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Just great presentation about the Pointless of many Powerpoint slideshows!

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PLOS Biology: A Field Guide to Genomics Research

PLOS Biology: A Field Guide to Genomics Research | "Life, the Universe and Everything" else in Science | Scoop.it
PLOS Biology is an open-access, peer-reviewed journal that features works of exceptional significance in all areas of biological science, from molecules to ecosystems, including works at the interface with other disciplines.
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PLOS Biology: The Assessment of Science: The Relative Merits of Post-Publication Review, the Impact Factor, and the Number of Citations

PLOS Biology: The Assessment of Science: The Relative Merits of Post-Publication Review, the Impact Factor, and the Number of Citations | "Life, the Universe and Everything" else in Science | Scoop.it
PLOS Biology is an open-access, peer-reviewed journal that features works of exceptional significance in all areas of biological science, from molecules to ecosystems, including works at the interface with other disciplines.
Gabriel Wallau's insight:

The assessment of scientific publications is an integral part of the scientific process. Here we investigate three methods of assessing the merit of a scientific paper: subjective post-publication peer review, the number of citations gained by a paper, and the impact factor of the journal in which the article was published. We investigate these methods using two datasets in which subjective post-publication assessments of scientific publications have been made by experts. We find that there are moderate, but statistically significant, correlations between assessor scores, when two assessors have rated the same paper, and between assessor score and the number of citations a paper accrues. However, we show that assessor score depends strongly on the journal in which the paper is published, and that assessors tend to over-rate papers published in journals with high impact factors. If we control for this bias, we find that the correlation between assessor scores and between assessor score and the number of citations is weak, suggesting that scientists have little ability to judge either the intrinsic merit of a paper or its likely impact. We also show that the number of citations a paper receives is an extremely error-prone measure of scientific merit. Finally, we argue that the impact factor is likely to be a poor measure of merit, since it depends on subjective assessment. We conclude that the three measures of scientific merit considered here are poor; in particular subjective assessments are an error-prone, biased, and expensive method by which to assess merit. We argue that the impact factor may be the most satisfactory of the methods we have considered, since it is a form of pre-publication review. However, we emphasise that it is likely to be a very error-prone measure of merit that is qualitative, not quantitative.

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Putting GenBank Data on the Map

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Completelly agree!!! Lack of these information is unacceptable!!

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Science Magazine: Sign In

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Students as Collaborators in Systems Biology Research

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Stanford Daily | Science’s Beautiful Uncertainty

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Why is Science Behind a Paywall?

Why is Science Behind a Paywall? | "Life, the Universe and Everything" else in Science | Scoop.it
Scientists’ work follows a consistent pattern. They apply for grants, perform their research, and publish the results in a journal. The process is so routine it almost seems inevitable. But what if...
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PLOS Biology: The Case for Open Preprints in Biology

PLOS Biology: The Case for Open Preprints in Biology | "Life, the Universe and Everything" else in Science | Scoop.it
PLOS Biology is an open-access, peer-reviewed journal that features works of exceptional significance in all areas of biological science, from molecules to ecosystems, including works at the interface with other disciplines.
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Government Attacks on Science on the Rise

Government Attacks on Science on the Rise | "Life, the Universe and Everything" else in Science | Scoop.it
What the hell is going on with my government? I’m used to attacks on science; they’ve been endemic for years now. Antivaxxers, global warming deniers, creationists, what have you.
Gabriel Wallau's insight:

Ya, it is not my government, but anyway not good times are coming for science is USA...I hope it won`t happen...

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Is the time right for a preprint server for life science? | Mendeley Blog

Is the time right for a preprint server for life science? | Mendeley Blog | "Life, the Universe and Everything" else in Science | Scoop.it
Academics in physics, economics, or math often think that life scientists (like myself) are weird because life science doesn't have a preprint server.
Gabriel Wallau's insight:

Really nice text poiting out some still fuzzy question about pre-print server!! it is really important think carefully about this subject..

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The Past, Present and Future of Scholarly Publishing

The Past, Present and Future of Scholarly Publishing | "Life, the Universe and Everything" else in Science | Scoop.it

worth reading!

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Open Access increases citation? A brief overview of two reports | Open Science

Open Access increases citation? A brief overview of two reports | Open Science | "Life, the Universe and Everything" else in Science | Scoop.it
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Editing of Targeted Genes Proved Possible in Monkeys

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Using a recently developed genome-editing technique called CRISPR, a Chinese team has successfully altered two target genes in cynomolgus monkeys, paving the way for the development of monkey models that mimic human diseases. This is the first evidence that CRISPR can work in primates and represents a big advance over previous successes in genetically modifying monkeys, in which genes were inserted randomly into the genome. Only two of the three target genes were modified, and not all cells carry the same modification, indicating more work needs to be done to perfect the timing of the modification. Beyond its significance for biomedical research, the new work raises the possibility that CRISPR will one day be used to change the genetic makeup of human embryos.

 

uoooohhhhhhhh!!! Fantastic!!

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PLOS Biology: What Can Article-Level Metrics Do for You?

PLOS Biology: What Can Article-Level Metrics Do for You? | "Life, the Universe and Everything" else in Science | Scoop.it
PLOS Biology is an open-access, peer-reviewed journal that features works of exceptional significance in all areas of biological science, from molecules to ecosystems, including works at the interface with other disciplines.
Gabriel Wallau's insight:

Article-level metrics (ALMs) provide a wide range of metrics about the uptake of an individual journal article by the scientific community after publication. They include citations, usage statistics, discussions in online comments and social media, social bookmarking, and recommendations. In this essay, we describe why article-level metrics are an important extension of traditional citation-based journal metrics and provide a number of example from ALM data collected for PLOS Biology.

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Mobile DNA | Abstract | In and out of the rRNA genes: characterization of Pokey elements in the sequenced Daphnia genome

Mobile DNA | Abstract | In and out of the rRNA genes: characterization of Pokey elements in the sequenced Daphnia genome | "Life, the Universe and Everything" else in Science | Scoop.it
Only a few transposable elements are known to exhibit site-specific insertion patterns, including the well-studied R-element retrotransposons that insert into specific sites within the multigene rDNA.
Gabriel Wallau's insight:

Only a few transposable elements are known to exhibit site-specific insertion patterns, including the well-studied R-element retrotransposons that insert into specific sites within the multigene rDNA. The only known rDNA-specific DNA transposon, Pokey (superfamily: piggyBac) is found in the freshwater microcrustacean, Daphnia pulex. Here, we present a genome-wide analysis of Pokey based on the recently completed whole genome sequencing project for D. pulex.

Results

Phylogenetic analysis of Pokey elements recovered from the genome sequence revealed the presence of four lineages corresponding to two divergent autonomous families and two related lineages of non-autonomous miniature inverted repeat transposable elements (MITEs). The MITEs are also found at the same 28S rRNA gene insertion site as the Pokey elements, and appear to have arisen as deletion derivatives of autonomous elements. Several copies of the full-length Pokey elements may be capable of producing an active transposase. Surprisingly, both families of Pokey possess a series of 200 bp repeats upstream of the transposase that is derived from the rDNA intergenic spacer (IGS). The IGS sequences within the Pokey elements appear to be evolving in concert with the rDNA units. Finally, analysis of the insertion sites of Pokey elements outside of rDNA showed a target preference for sites similar to the specific sequence that is targeted within rDNA.

Conclusions

Based on the target site preference of Pokey elements and the concerted evolution of a segment of the element with the rDNA unit, we propose an evolutionary path by which the ancestors of Pokey elements have invaded the rDNA niche. We discuss how specificity for the rDNA unit may have evolved and how this specificity has played a role in the long-term survival of these elements in the subgenus Daphnia.

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Am I still a scientist? - Moore - 2013 - BioEssays - Wiley Online Library

Am I still a scientist? - Moore - 2013 - BioEssays - Wiley Online Library | "Life, the Universe and Everything" else in Science | Scoop.it
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Trends in Ecology and Evolution - The academic welfare state: making peer-review count

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The peer-review process is a central pillar of academic publishing. However, the work that goes into ensuring the quality of published content is rarely recognised. Here we present a correction factor for the h-index, one of the most popular metrics for quantifying academic output, that will allow for the inclusion of peer-review effort in the evaluation of the outputs produced by an academic.

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Big biology: The ’omes puzzle

Big biology: The ’omes puzzle | "Life, the Universe and Everything" else in Science | Scoop.it
Where once there was the genome, now there are thousands of ’omes. Nature goes in search of the ones that matter.
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CineversityTV's curator insight, September 14, 2013 8:09 AM

the genetic miracle

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Beyond transposons: the epigenetic and s... [Curr Opin Cell Biol. 2013]

Beyond transposons: the epigenetic and s... [Curr Opin Cell Biol. 2013] | "Life, the Universe and Everything" else in Science | Scoop.it
PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gabriel Wallau's insight:

Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigenetic and post-transcriptional regulation of gene expression. In addition, the function of this pathway in somatic cells has also been more systematically characterized. The new findings reveal the Piwi-piRNA pathway as a more general mechanism of gene regulation.

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Impact Factor Distortions

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Scientists Embrace Openness | Science Careers

Scientists Embrace Openness | Science Careers | "Life, the Universe and Everything" else in Science | Scoop.it
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Transformation Is Possible if a University Really Cares

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The way that most research universities across North America teach science to undergraduates is worse than ineffective, says Carl Wieman. It's unscientific. A Nobel Prize–winning physicist turned science educator, Wieman doesn't understand why institutions of higher education would disregard decades of research showing the superiority of student-centered, active learning over the traditional 50-minute lecture. Wieman has spent the past 15 years applying the science of learning to how undergraduate science courses are taught, making impressive strides in changing how individual faculty members teach. Those changes have translated into big improvements in student learning.

 

Really nice paper, something we should look foward!!

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X Chromosome Inactivation | Learn Science at Scitable

X Chromosome Inactivation | Learn Science at Scitable | "Life, the Universe and Everything" else in Science | Scoop.it
The sex chromosomes raise an interesting dilemma: females (XX) carry twice as many X-linked genes as males (XY), and this double dose is lethal to the early embryo. So how does nature resolve this problem?
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Open access for the people

Open access for the people | "Life, the Universe and Everything" else in Science | Scoop.it
How to make research intelligible | Stephen Curry
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