La perception extra-sensorielle durant telephone est en plein impulsion
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Synthesis and Biological Evaluation of a New Series of Highly Functionalized 7′-homo-Anhydrovinblastine Derivatives

Synthesis and Biological Evaluation of a New Series of Highly Functionalized 7′-homo-Anhydrovinblastine Derivatives | La perception extra-sensorielle durant telephone est en plein impulsion | Scoop.it

Sixteen new 7′-homo-anhydrovinblastine derivatives were prepared in one or two steps from vinorelbine by means of an original and regiospecific rearrangement and subsequent diastereoselective reduction. This strategy has allowed fast access to a family of vinca alkaloid derivatives with an enlarged and functionalized ring C′. Their synthesis and biological evaluation are reported. One compound (compound 35) is 1.7 times more active than vinorelbine as a tubulin assembly inhibitor. Moreover, some of these compounds are highly cytotoxic, and two of them are more potent than vinorelbine on HCT116 and K562 cell lines. Molecular modeling studies, carried out with two of the new vinca derivatives, provide useful hints about how a given functionalization introduced at positions 7′ and 8′ of the C′ ring results in improved binding interactions between one of the new derivatives and the interdimer interface when compared to the parent compound vinblastine.

 

Olga Gherbovet†, Claire Coderch‡, María Concepción García Alvarez†, Jérôme Bignon†, Sylviane Thoret†, Marie-Thèrese Martin†, Françoise Guéritte†, Federico Gago‡, and Fanny Roussi

J. Med. Chem., Article ASAP

DOI: 10.1021/jm4004347

Publication Date (Web): July 3, 2013 


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Mise à jour PANDA le 21 décembre2012 (v. 23)

Mise à jour PANDA le 21 décembre2012 (v. 23) | La perception extra-sensorielle durant telephone est en plein impulsion | Scoop.it
google PANDA version 23 du 21 décembre 2012
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Mise à jour PANDA le 21 décembre2012 (v. 23)

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Contact - Agence M3 Communication - Aix en Provence / Marseille

M3 Communication réalise tous vos projets de communication Print - Web - Signalétique.
Agence de communication accompagnant les entreprises d'Aix-en-Provence, Marseille, Paris
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Real Free Tarot - online card reading

Real Free Tarot - online card reading | La perception extra-sensorielle durant telephone est en plein impulsion | Scoop.it
Real Free Tarot, draw the tarot cards online and find the answers 24/7, just when you need it. Daily update horoscope western and chinese.
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Referencement google gratuit ?!

Referencement google gratuit ?! | La perception extra-sensorielle durant telephone est en plein impulsion | Scoop.it
Referencement Google gratuit ?! Faut-il y croire et est-ce LA solution ?
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Referencement google gratuit ?!

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Origine de la Géomancie

Origine de la Géomancie | La perception extra-sensorielle durant telephone est en plein impulsion | Scoop.it
La Géomancie est un ancien art divinatoire dont on trouve les origines en Perse et dans les pays de l’Afrique du nord.
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La perception extra-sensorielle durant telephone se reveler franco survol

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Real Free Tarot - online card reading

Real Free Tarot - online card reading | La perception extra-sensorielle durant telephone est en plein impulsion | Scoop.it
Real Free Tarot, draw the tarot cards online and find the answers 24/7, just when you need it. Daily update horoscope western and chinese.
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AstroPhoto! Fantastique paysage stellaire par Sean Parker

AstroPhoto! Fantastique paysage stellaire par Sean Parker | La perception extra-sensorielle durant telephone est en plein impulsion | Scoop.it
A great shot of the beautiful night-time sky by astrophotographer Sean Parker! Sean used a Canon 5DMKII, Nikkor 14-24MM F/2.8 at 20 seconds and ISO 1000, and processed the image with Adobe Lightroom.

Via Leopoldo Benacchio, COSMOSPACE
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