At first blush, it may sound a little nuts to willingly ask someone to place multiple needles in your skin, but proponents say the practice is useful for alleviating a variety of ailments, from chronic pain to depression.
Current therapy for controlling human immunodeficiency virus (HIV-1) infection and preventing acquired immunodeficiency syndrome (AIDS) progression has profoundly decreased viral replication in cells susceptible to HIV-1 infection, but it does not eliminate the low level of viral replication in latently infected cells, which contain integrated copies of HIV-1 proviral DNA. There is an urgent need for the development of HIV-1 genome eradication strategies that will lead to a permanent or “sterile” cure of HIV-1/AIDS. In the past few years, novel nuclease-initiated genome editing tools have been developing rapidly, including zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the CRISPR/Cas9 system. These surgical knives, which can excise any genome, provide a great opportunity to eradicate the HIV-1 genome by targeting highly conserved regions of the HIV-1 long terminal repeats or essential viral genes. Given the time consuming and costly engineering of target-specific ZFNs and TALENs, the RNA-guided endonuclease Cas9 technology has emerged as a simpler and more versatile technology to allow permanent removal of integrated HIV-1 proviral DNA in eukaryotic cells, and hopefully animal models or human patients. The major unmet challenges of this approach at present include inefficient nuclease gene delivery, potential off-target cleavage, and cell-specific genome targeting. Nanoparticle or lentivirus-mediated delivery of next generation Cas9 technologies including nickase or RNA-guided FokI nuclease (RFN) will further improve the potential for genome editing to become a promising approach for curing HIV-1/AIDS.
Lord Vishnu, 1st Deity of the Indian Trinity: the Lord maintainer of all the universes resting/sitting on and supported by Lord ananta-Sesha (who controls universal laws such as gravity). | See more about Deities, Hindus and The Lord.
Carnegie Mellon University announced a plan today to shave energy costs by $2 million annually across more than three dozen buildings on its Oakland campus by improving efficiency with a cloud-based analytics system.
A compact fusion reactor presented by Skunk Works, the stealth experimental technology section of Lockheed Martin. It's about the size of a jet engine and it can fuel airplanes, most likely spaceships, and cities.
First… what's a chakra? Chakras are measurable patterns of electromagnetic activity and centers for the reception, assimilation and transmission of life energies. Each chakra is associated with a color, a sound/note and a part of the body.
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