Doctor Otto Warburg also wrote in 1931 about oxygen's relationship to the pH of cancer cells' internal environments. Since fermentation was a major metabolic pathway of cancer cells, Warburg reported cancer cells maintain a lower pH, as low as 6.0, due to lactic acid production and elevated CO2. He firmly believed there was a direct relationship between pH and oxygen.
When frustrated by the lack of acceptance of his ideas, Warburg was known to quote an aphorism he attributed to Max Planck: Science progresses not because scientists change their minds, but rather because scientists attached to erroneous views die, and are replaced.
Seemingly utterly convinced of the accuracy of his conclusions, Warburg expressed dismay at the "continual discovery of cancer agents and cancer viruses" which he expected to "hinder necessary preventative measures and thereby become responsible for cancer cases".
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