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Jeff Morris
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Marine Corps tests autonomous mini-truck

Marine Corps tests autonomous mini-truck | Jeff Morris | Scoop.it
In a small taste of things to come in military operations, the US Marine Corps has tested the mettle of a self-driving mini-truck at the 2014 RIMPAC interna...
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Twitter URL Shortening Service (t.co) Most Abused by Spammers

Twitter URL Shortening Service (t.co) Most Abused by Spammers | Jeff Morris | Scoop.it

The t.co short URL service from Twitter is used more than any other by spammers to deliver links to pharmacy websites that distribute counterfeit products. Andrew Conway from San Francisco-based Cloudmark, a company that offers protection against email threats, reports that at the moment, more than half (54%) of the short links blacklisted by them use Twitter’s service.

He said that the spam using t.co short links comes in outbreaks that last between four and six weeks, one reason for this probably being the time required by Twitter to identify the attack and adjust its abuse filters to prevent users from reaching malicious pages.


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TRAP-1 knock-out mice show signs of longer lives with fewer age-related diseases

TRAP-1 knock-out mice show signs of longer lives with fewer age-related diseases | Jeff Morris | Scoop.it

While developing a new cancer drug, researchers at The Wistar Institute discovered that mice lacking a specific protein live longer lives with fewer age-related illnesses. The mice, which lack the TRAP-1 protein, demonstrated less age-related tissue degeneration, obesity, and spontaneous tumor formation when compared with normal mice. Their findings could change how scientists view the metabolic networks within cells.

 

In healthy cells, TRAP-1 is an important regulator of metabolism and has been shown to regulate energy production in mitochondria, organelles that generate chemically useful energy for the cell. In the mitochondria of cancer cells, TRAP-1 is universally overproduced.  

 

The Wistar team’s report, which appears in the journal Cell Reports (available online now), shows how “knockout” mice bred to lack the TRAP-1 protein compensate for this loss by switching to alternative cellular mechanisms for making energy.

 

“We see this astounding change in TRAP-1 knockout mice, where they show fewer signs of aging and are less likely to develop cancers,” said Dario C. Altieri. M.D., Robert and Penny Fox Distinguished Professor and director of The Wistar Institute’s National Cancer Institute-designated Cancer Center. “Our findings provide an unexpected explanation for how TRAP-1 and related proteins regulate metabolism within our cells.”

 

“We usually link the reprogramming of metabolic pathways with human diseases, such as cancer,” Altieri said. “What we didn’t expect to see were healthier mice with fewer tumors.”

 

Altieri and his colleagues created the TRAP-1 knockout mice as part of their ongoing investigation into their novel drug, Gamitrinib, which targets the protein in the mitochondria of tumor cells. TRAP-1 is a member of the heat shock protein 90 (HSP90) family, which are “chaperone” proteins that guide the physical formation of other proteins and serve a regulatory function within mitochondria. Tumors use HSP90 proteins, like TRAP-1, to help survive therapeutic attack. 

“In tumors, the loss of TRAP-1 is devastating, triggering a host of catastrophic defects, including metabolic problems that ultimately result in the death of the tumor cells,” Altieri said.  “Mice that lack TRAP-1 from the start, however, have three weeks in the womb to compensate for the loss of the protein.”

 

The researchers found that in their knockout mice, the loss of TRAP-1 causes mitochondrial proteins to misfold, which then triggers a compensatory response that causes cells to consume more oxygen and metabolize more sugar. This causes mitochondria in knockout mice to produce deregulated levels of ATP, the chemical used as an energy source to power all the everyday molecular reactions that allow a cell to function.


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Acoustic bottle beams hold promise for acoustic imaging, cloaking and levitation

Acoustic bottle beams hold promise for acoustic imaging, cloaking and levitation | Jeff Morris | Scoop.it
Scientists at the University of California Berkeley claim to have produced a bottle beam of acoustic energy that can precisely direct sound waves through ...
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A Lizard Interloper Presents Challenge in Florida

A Lizard Interloper Presents Challenge in Florida | Jeff Morris | Scoop.it
Losing the battle with Burmese pythons, Florida wildlife biologists are fighting back against the tegu, the latest nonnative species to find a comfortable home out in the Everglades.
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Facebook iPhone 6 scams - how NOT to get sucked in

Facebook iPhone 6 scams - how NOT to get sucked in | Jeff Morris | Scoop.it
We "do the math" to help you explain to your friends and family why they are NOT getting a free iPhone 6 for clicking Like!
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Registry-infecting reboot-resisting malware has NO FILES

Registry-infecting reboot-resisting malware has NO FILES | Jeff Morris | Scoop.it
Anti-virus doesn't stand a chance becuase there's nothing for it to scan
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NASA says puzzling new space drive can generate thrust without propellant

NASA says puzzling new space drive can generate thrust without propellant | Jeff Morris | Scoop.it
A NASA study has recently concluded that the Cannae Drive, a disruptive new method of space propulsion, can produce small amounts of thrust without the us...
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Engineered biomaterial may regenerate damaged skeletal muscle | KurzweilAI

Engineered biomaterial may regenerate damaged skeletal muscle | KurzweilAI | Jeff Morris | Scoop.it

Jeffrey Wolchok, right, works with a biomaterial that can regenerate damaged skeletal muscle (credit: University of Arkansas) A biomaterial that can


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Cigarette butts transformed into high-performance supercapacitor component

Cigarette butts transformed into high-performance supercapacitor component | Jeff Morris | Scoop.it
Billions of cigarette butts are discarded around the world each year, but new research suggests they could be set for a new lease on life with scientists de...
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Boeing begins program to produce aviation biofuel from hybrid tobacco plants

Boeing begins program to produce aviation biofuel from hybrid tobacco plants | Jeff Morris | Scoop.it
Test farms are already up and running, with Boeing hoping to use local tobacco growing lands and expertise to produce sustainable biofuel without impacting ...
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Edward Snowden's not a one-off: US.gov hunts new secret doc leaker

Edward Snowden's not a one-off: US.gov hunts new secret doc leaker | Jeff Morris | Scoop.it
Poor old Julian Assange – whistleblower went straight to Glenn Greenwald
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1.2 Billion Internet Credentials Discovered in the Hands of Russian Crime Ring

1.2 Billion Internet Credentials Discovered in the Hands of Russian Crime Ring | Jeff Morris | Scoop.it
Security researchers have reportedly found the largest collection of Internet username credentials, including passwords and more than 500 million email addresses. According to researchers at Hold Security, the defrauded collection was found in the hands of a Russian crime ring with data gathered from about 420,000 different websites. The collection has been confirmed to be …… Read More

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Single injection reverses type 2 diabetes symptoms in mice without side effects

Single injection reverses type 2 diabetes symptoms in mice without side effects | Jeff Morris | Scoop.it
A new generation of safer and more effective diabetes drugs could be in the offing with researchers at the Salk Institute discovering that when mice with di...
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How to send 5 million spam emails without even noticing

How to send 5 million spam emails without even noticing | Jeff Morris | Scoop.it
Before you read the article, see if you can guess, to the nearest million, how many spams a 10,000-strong botnet might realistically send each week.

Commit yourself first, and then read the stor...
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China boots Kaspersky and Symantec off security contractor list

China boots Kaspersky and Symantec off security contractor list | Jeff Morris | Scoop.it
Foreign firms dropped from roll of approved infosec vendors
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World-record 43 Tbps data transfer speed set by Danish researchers

World-record 43 Tbps data transfer speed set by Danish researchers | Jeff Morris | Scoop.it
Using a new type of optical fiber, researchers at the Technical University of Denmark (DTU) have transmitted data over a single optical fiber at a speed of ...
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The Marines’ Self-Flying Chopper Survives a Three-Year Tour | Autopia | WIRED

The Marines’ Self-Flying Chopper Survives a Three-Year Tour | Autopia | WIRED | Jeff Morris | Scoop.it
Back in 2010, the Navy decided it could use a self-flying helicopter, to take over dangerous missions delivering cargo to Marine Corps stations in Afghanistan.
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