iPS
13 views | +0 today
Follow
Your new post is loading...
Your new post is loading...
Rescooped by Robert J. Chen from iPS
Scoop.it!

Near-perfect and rapid generation of induced pluripotent stem cells


Via Jacob Blumenthal, Robert J. Chen
more...
Jacob Blumenthal's curator insight, September 21, 2013 2:31 PM

A research team from the Weizmann Institute of Science in Israel, led by Dr. Yakub Hanna have discovered a protein that prevents the effective generation of induced pluripotent stem (iPS) cells. The protein, MDB3, is expressed  in every cell in the body, at every stage of development.  The researchers found that there is one exception to the rule of universal expression of this protein: the first three days after conception. These are exactly the three days in which the fertilized egg begins dividing, and the nascent embryo is a growing ball of pluripotent stem cells that will eventually supply all the cell types in the body. Starting on the fourth day, differentiation begins and the cells already start to lose their pluripotent status. And that is just when the MBD3 proteins first appear. By removing this protein from adult cells, the efficiency of the stem cells generation increased from 1% to almost 100%. Moreover, the process itself was shortened from  4 weeks to 8 days. The low efficient production of iPS cells using non-viral systems was one of the major setbacks in using these cells for regenerative medicine therapies. These amazing findings may help facilitate the efficient production of stem cells for medical use, as well as advancing our understanding of the mysterious process cell reprogramming by which mature cells can revert back into their original, embryonic state.

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12587.html

Robert J. Chen's curator insight, September 23, 2013 10:13 PM

Closer to clinical implementation?

Rescooped by Robert J. Chen from Stem Cells & Tissue Engineering
Scoop.it!

Near-perfect and rapid generation of induced pluripotent stem cells


Via Jacob Blumenthal
Robert J. Chen's insight:

Closer to clinical implementation?

more...
Jacob Blumenthal's curator insight, September 21, 2013 2:31 PM

A research team from the Weizmann Institute of Science in Israel, led by Dr. Yakub Hanna have discovered a protein that prevents the effective generation of induced pluripotent stem (iPS) cells. The protein, MDB3, is expressed  in every cell in the body, at every stage of development.  The researchers found that there is one exception to the rule of universal expression of this protein: the first three days after conception. These are exactly the three days in which the fertilized egg begins dividing, and the nascent embryo is a growing ball of pluripotent stem cells that will eventually supply all the cell types in the body. Starting on the fourth day, differentiation begins and the cells already start to lose their pluripotent status. And that is just when the MBD3 proteins first appear. By removing this protein from adult cells, the efficiency of the stem cells generation increased from 1% to almost 100%. Moreover, the process itself was shortened from  4 weeks to 8 days. The low efficient production of iPS cells using non-viral systems was one of the major setbacks in using these cells for regenerative medicine therapies. These amazing findings may help facilitate the efficient production of stem cells for medical use, as well as advancing our understanding of the mysterious process cell reprogramming by which mature cells can revert back into their original, embryonic state.

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12587.html

Scooped by Robert J. Chen
Scoop.it!

National public umbilical cord blood bank launches to gather vital stem cells - Ottawa Citizen

National public umbilical cord blood bank launches to gather vital stem cells - Ottawa Citizen | iPS | Scoop.it
Ottawa Citizen
National public umbilical cord blood bank launches to gather vital stem cells
Ottawa Citizen
OTTAWA - Canada's first national public blood bank for umbilical cord blood is set to begin taking donations today at an Ottawa hospital.
more...
No comment yet.