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Human Papillomavirus–Associated Cancers — United States, 2008–2012 | MMWR

The Morbidity and Mortality Weekly Report (MMWR) Series is prepared by the Centers for Disease Control and Prevention (CDC).
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High-Risk HPV Prevalent in Oropharyngeal Cancers

High-Risk HPV Prevalent in Oropharyngeal Cancers | Interesting ORL articles | Scoop.it
The Centers for Disease Control and Prevention (CDC) reports that in a large sample of invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% were positive for high-risk HPV types 16 and 18, which are covered by the 2 commercially available vaccines (Gardasil, Merck & Co.; Cervarix, GlaxoSmithKline).
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HPV16 in the Mouth Linked to Increased Risk for HNSCC

HPV16 in the Mouth Linked to Increased Risk for HNSCC | Interesting ORL articles | Scoop.it
The detection of human papillomavirus (HPV) type 16 in the mouth was associated with a 22-fold increased risk for oropharyngeal cancer in a new study.
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Chemoprophylaxis for Venous Thromboembolism

Patients with Caprini VTE risk scores greater than 7 were less likely to have a VTE with perioperative chemoprophylaxis (5.3% vs 10.4%; P = .06). Of patients with VTE chemoprophylaxis, 3.5% developed a bleeding complication compared with 1.2% of patients without prophylaxis (P < .001). Bleeding complications were associated with concomitant use of antiplatelet medications and chemoprophylaxis. Among patients undergoing free tissue transfer, chemoprophylaxis significantly decreased the incidence of VTE (2.1% vs 7.7%; P = .002) and increased bleeding complications (11.9% vs 4.5%; P = .01). In all other patients, VTE chemoprophylaxis did not significantly influence the likelihood of VTE (1.0% vs 0.6%; P = .12) or bleeding (1.5% vs 0.9%; P = .15).
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Effectiveness and safety of VTE chemoprophylaxis differed between patient subgroups, defined by Caprini risk score and by procedure. Effectiveness was most evident in patients with high Caprini risk scores and microvascular free tissue reconstruction. Bleeding complications were associated with VTE chemoprophylaxis administered in close proximity to potent antiplatelet therapy. The Caprini risk assessment model appears to be an effective tool to stratify otolaryngology patients by risk for VTE. Patients undergoing free tissue reconstruction merit further study before developing recommendations for VTE prophylaxis because of their higher risk of both VTE and bleeding.

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SLNB for Head and Neck Melanoma

SLNB for Head and Neck Melanoma | Interesting ORL articles | Scoop.it
This SEER cohort analysis demonstrates no significant association between SLNB and improved disease-specific survival for patients with HNM.
Xianglei WU's insight:

One of TOP 10 papers from JAMA-ORL

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WAO Journal | Full text | Sublingual immunotherapy: World Allergy Organization position paper 2013 update

We have prepared this document, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update”, according to the evidence-based criteria, revising and updating chapters of the originally published paper, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2009”, available at http://www.waojournal.org. Namely, these comprise: “Mechanisms of sublingual immunotherapy;” “Clinical efficacy of sublingual immunotherapy” – reporting all the data of all controlled trials published after 2009; “Safety of sublingual immunotherapy” – with the recently published Grading System for adverse reactions; “Impact of sublingual immunotherapy on the natural history of respiratory allergy” – with the relevant evidences published since 2009; “Efficacy of SLIT in children” – with detailed analysis of all the studies; “Definition of SLIT patient selection” – reporting the criteria for eligibility to sublingual immunotherapy; “The future of immunotherapy in the community care setting”; “Methodology of clinical trials according to the current scientific and regulatory standards”; and “Guideline development: from evidence-based medicine to patients' views” – including the evolution of the methods to make clinical recommendations.
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Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells

Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells | Interesting ORL articles | Scoop.it
Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is expressed in human nasopharyngeal and respiratory epithelium and has demonstrated antimicrobial activity. SPLUNC1 is now referred to as bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1). Reduced BPIFA1 expression is associated with bacterial colonization in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Interleukin 13 (IL-13), predominately secreted by T helper 2 (T H 2) cells, has been found to contribute to airway allergies and suppress BPIFA1 expression in nasal epithelial cells. However, the molecular mechanism of IL-13 perturbation of bacterial infection and BPIFA1 expression in host airways remains unclear. In this study, we found that lipopolysaccharide (LPS)-induced BPIFA1 expression in nasal epithelial cells was mediated through the JNK/c-Jun signaling pathway and AP-1 activation. We further demonstrated that IL-13 downregulated the LPS-induced activation of phosphorylated JNK and c-Jun, followed by attenuation of BPIFA1 expression. Moreover, the immunohistochemical analysis showed that IL-13 prominently suppressed BPIFA1 expression in eosinophilic CRSwNP patients with bacterial infection. Taken together, these results suggest that IL-13 plays a critical role in attenuation of bacteria-induced BPIFA1 expression that may result in eosinophilic CRSwNP.
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JAMA Network | JAMA Otolaryngology–Head & Neck Surgery | Assessment of Vocal Fold Function Using Transcutaneous Laryngeal Ultrasonography and Flexible Laryngoscopy

JAMA Network | JAMA Otolaryngology–Head & Neck Surgery | Assessment of Vocal Fold Function Using Transcutaneous Laryngeal Ultrasonography and Flexible Laryngoscopy | Interesting ORL articles | Scoop.it
When evaluation of vocal fold function is indicated in patients undergoing thyroid and parathyroid surgery, TLUSG should not be considered as an alternative to the current practice of flexible fiberoptic laryngoscopy.
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Gene Expression Classifier Testing for Patients With Thyroid Nodules

Gene Expression Classifier Testing for Patients With Thyroid Nodules | Interesting ORL articles | Scoop.it
This study examines surgical decisions made for patients with indeterminate thyroid nodules who underwent gene expression classifier (GEC) testing and compares actual vs recommended treatments to determine the effects on management of GEC testing.
Xianglei WU's insight:

This study suggested a debate vs. previous reports

(relevant references: Walsh PS et al, Journal of Clinical Endocrinology & Metabolism, 2012; Chudova D, et al, Journal of Clinical Endocrinology & Metabolism, 2010; Duick DS et al, Thyroid, 2012; Alexander EK et al, Journal of Clinical Endocrinology & Metabolism, 2014)

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CPAP Treatment Motivator: Better Golf Scores

CPAP Treatment Motivator:  Better Golf Scores | Interesting ORL articles | Scoop.it
In patients with obstructive sleep apnea, treatment with CPAP significantly improved golf scores; researchers suggest nonmedical performance may be strong motivator for treatment compliance.
Xianglei WU's insight:

N'importe quoi. A grant from the Boston Children's Hospital Department of Medicine Quality Improvement Publication.

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Alcohol and Cancer: Drink at Your Own Risk

Alcohol and Cancer: Drink at Your Own Risk | Interesting ORL articles | Scoop.it
Alcohol consumption has been causally linked to nine cancers, including female breast cancer, and recent evidence has begun to clarify the factors that affect an individual's risk.
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In 2012, alcohol consumption caused 5.5% of all cases of cancer and 5.8% of all cancer deaths.

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Transoral robotic surgery demonstrates efficacy in head, neck cancers

Transoral robotic surgery demonstrates efficacy in head, neck cancers | Interesting ORL articles | Scoop.it
Transoral robotic surgery appeared associated with favorable oncologic outcomes for patients with head and neck cancers, according to the results of a multi-institutional study.Patients with oropharyngeal cancer derived the greatest benefit from transoral robotic surgery (TORS), a minimally invasive surgical technique, according to the researchers.
Xianglei WU's insight:

An excellent technique for oropharyngeal cancer.

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Robotic surgery and oropharyngeal cancer

Prof Terry Day - (Medical University of South Carolina, Charleston, USA) talks to ecancertv at IAOO 2015 about the benefits of robotic surgery in oropharyngeal ...

Via Gilbert C FAURE
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Subcutaneous Treatment for Chronic Sinusitis With Nasal Polyposis

Subcutaneous Treatment for Chronic Sinusitis With Nasal Polyposis | Interesting ORL articles | Scoop.it
Research from JAMA — Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis — A Randomized Clinical Trial
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Among adults with symptomatic chronic sinusitis and nasal polyposis refractory to intranasal corticosteroids, the addition of subcutaneous dupilumab to mometasone furoate nasal spray compared with mometasone alone reduced endoscopic nasal polyp burden after 16 weeks. 

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Unknown Primary Head/Neck SCC More Common

Unknown Primary Head/Neck SCC More Common | Interesting ORL articles | Scoop.it
NEW YORK (Reuters Health) - The last decade has seen an increase in the frequency of unknown primary squamous cell carcinoma (UPSCC) of the head and neck, and human papillomavirus (HPV) is behind most of these cases, new research suggests.
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Monocentric study;

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PCR-Based Detection of HPV–Related Cancer

PCR-Based Detection of HPV–Related Cancer | Interesting ORL articles | Scoop.it
. The sensitivity, specificity, negative predictive value, and positive predictive value of combined saliva and plasma pretreatment HPV-16 DNA status for detecting tumor HPV-16 status were 76%, 100%, 42%, and 100%, respectively. The sensitivities of pretreatment saliva or plasma alone were 52.8% and 67.3%, respectively. In a multivariable analysis, positive posttreatment saliva HPV status was associated with higher risk of recurrence (hazard ratio [HR], 10.7; 95% CI, 2.36-48.50) (P = .002). Overall survival was reduced among those with posttreatment HPV-positive status in saliva (HR, 25.9; 95% CI, 3.23-208.00) (P = .002) and those with HPV-positive status in either saliva or plasma but not among patients with HPV-positive status in plasma alone. The combined saliva and plasma posttreatment HPV-16 DNA status was 90.7% specific and 69.5% sensitive in predicting recurrence within 3 years.
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Tonsillar H pylori Colonization in Tonsillitis

Helicobacter pylori colonization was not found to be more prevalent on tonsillar tissue with chronic or recurrent infections. The reviewed studies provide no evidence that H pylori infection plays a role in the pathogenesis or development of chronic tonsillitis.
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Cognitive Training and D-Cycloserine for Tinnitus

Cognitive Training and D-Cycloserine for Tinnitus | Interesting ORL articles | Scoop.it

Use of a computer-based CT program with a putative neuroplasticity-sensitizing drug, D-cycloserine, was feasible and well tolerated. With the limited sample size, the adjuvant use of D-cycloserine was no more effective than placebo at improving tinnitus bother. The finding that D-cycloserine use was more effective than placebo at improving self-reported cognitive difficulties could be important given the high rate of concern for cognitive deficits in patients with tinnitus. D-cycloserine and other putative neuroplasticity-facilitating agents could be investigated in the future as a strategy to enhance neuroplasticity–based tinnitus treatments.

Xianglei WU's insight:

Cycloserine is restricted for use only against multiple drug-resistant and extensively drug-resistant strains of M. tuberculosis. Another reason for limited use of this drug is the neurological side effects it causes, since it is able to penetrate into the central nervous system (CNS) and cause headaches, drowsiness, depression, dizziness, vertigo, confusion, paresthesias, dysarthria, hyperirritability, psychosis, convulsions, and shaking (tremors).

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Allergen Immunotherapy: An Update on Protocols of Administration

Allergen Immunotherapy: An Update on Protocols of Administration | Interesting ORL articles | Scoop.it
the efficacy of only preseasonal subcutaneous AIT was demonstrated for tree and grass pollen. Sublingual AIT was shown to be effective and well tolerated in allergic rhinitis and asthma with tablets and with highly concentrated liquid formulations (ragweed, house dust mite), but not cockroach. For food allergy, oral immunotherapy is promising, but close attention should be paid to the exact administration schedule, maintenance dose, and the definition of efficacy (desensitization or real tolerance, as defined by a negative challenge test at least 4 months off treatment).
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Gilbert C FAURE's curator insight, December 29, 2015 3:34 AM

you should be registered

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JAMA Network | JAMA Otolaryngology–Head & Neck Surgery | Rigid Esophagoscopy for Head and Neck Cancer Staging and the Incidence of Synchronous Esophageal Malignant Neoplasms

JAMA Network | JAMA Otolaryngology–Head & Neck Surgery | Rigid Esophagoscopy for Head and Neck Cancer Staging and the Incidence of Synchronous Esophageal Malignant Neoplasms | Interesting ORL articles | Scoop.it

 No synchronous primary esophageal carcinomas were detected. The incidence of synchronous esophageal malignant neoplasms found on screening endoscopy based on literature review and on SEER data set analysis was very low and has decreased from 1980 to 2010 in North America. The incidence reported in South America and Asia was relatively high.

Xianglei WU's insight:

For patients in South America and Asia, how to evaluate its value ?

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Tonsillectomy and Adenoidectomy in Pediatric Obstructive Sleep Apnea

Tonsillectomy and Adenoidectomy in Pediatric Obstructive Sleep Apnea | Interesting ORL articles | Scoop.it
This cohort study quantifies polysomnography and clinical outcomes of intracapsular and extracapsular tonsillectomy and adenoidectomy for treatment of pediatric obstructive sleep apnea syndrome.
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"when comorbid diagnoses of both asthma and obesity exist, OSAS is likely to be refractory to treatment with ITA compared with ETA"

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FDA Clears Novel Hearing Aid EarLens

FDA Clears Novel Hearing Aid EarLens | Interesting ORL articles | Scoop.it
The US Food and Drug Administration (FDA) yesterday cleared a new hearing aid that uses a laser diode and direct vibration of the eardrum to amplify sound.
Xianglei WU's insight:

Sounds interesting but how to resolve pratically the routine maintenance since it is placed deep in the ear canal ? 

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Nerve Stimulation Still Effective at 3 Years for OSA

Nerve Stimulation Still Effective at 3 Years for OSA | Interesting ORL articles | Scoop.it
Patients with obstructive sleep apnea maintain clinical benefits 3 years after being implanted with a device that stimulates their hypoglossal nerve, follow-up data show.
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Endoscopic Endonasal Repair of Spontaneous and Traumatic Cerebrospinal Fluid Rhinorrhea: A Review and Local Experience

Endoscopic Endonasal Repair of Spontaneous and Traumatic Cerebrospinal Fluid Rhinorrhea: A Review and Local Experience | Interesting ORL articles | Scoop.it
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