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Institut Pasteur de Tunis-معهد باستور تونس
L’Institut Pasteur de Tunis (IPT) est un établissement public de santé et de recherche scientifique.







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Using Social Media for Health

Using Social Media for Health | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Infographic-How-Are-Consumers-Using-Social-Media-for-Health
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Researchers alter mosquito genome with goal of controlling disease

Researchers alter mosquito genome with goal of controlling disease | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
With a technique called TALENS, scientists used a pair of engineered proteins to disrupt a targeted gene in the mosquito genome, changing the eye color of ensuing generations of the insect.
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Bernadette Cassel's curator insight, March 26, 2013 5:53 AM

 

Des chercheurs ont utilisé avec succès une technique de disruption génique* pour changer la couleur des yeux d'un moustique - une étape cruciale vers de nouvelles stratégies génétiques visant à perturber la transmission de maladies telles que la dengue.

 

(d'après le résumé de l'article)

 

* interruption de la séquence codante d'un gène par introduction d'une autre séquence d'ADN

 

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4000 personnes meurent chaque jour de la tuberculose - Toute l'actualité infirmière avec Actusoins | Toute l'actualité infirmière avec Actusoins

4000 personnes meurent chaque jour de la tuberculose - Toute l'actualité infirmière avec Actusoins | Toute l'actualité infirmière avec Actusoins | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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Britain ponders 'three-person embryos' to combat genetic diseases

Britain ponders 'three-person embryos' to combat genetic diseases | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
If given green light, British scientists would be the first to offer treatments letting babies be born with DNA from three people
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Modified Cold Sore Virus Shrinks Melanoma Tumors, Amgen Says - Forbes

Modified Cold Sore Virus Shrinks Melanoma Tumors, Amgen Says - Forbes | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Transmission electron micrograph of herpes simplex virus (Photo credit: Wikipedia) A genetically modified version of herpes simplex virus type 1, the same virus that causes cold sores, shrank tumors of the deadly skin cancer melanoma in a clinical...
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Unlocking the Mysteries of Extracellular RNA Communication

Once thought to exist only inside cells, RNA is now known to travel outside of cells and play a role in newly discovered mechanisms of cell-to-cell communica...
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Vaginal gel loaded with bee venom may destroy HIV

Vaginal gel loaded with bee venom may destroy HIV | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Scientists develop nanoparticles to destroy HIV with bee venom, before infection even occurs.
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Sida : ces patients qui contrôlent leur infection

Sida : ces patients qui contrôlent leur infection | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
L'étude des - rares - malades en rémission sans traitement pourrait déboucher sur la mise au point d'un moyen d'éradiquer le sida.
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CIDRAP >> Human cell receptor for novel coronavirus discovered

CIDRAP >> Human cell receptor for novel coronavirus discovered | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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This Protein Could Change Biotech Forever - Forbes

This Protein Could Change Biotech Forever - Forbes | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
It started with a quest to make better yogurt.
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Picture the world without tuberculosis – PATH Blog

Picture the world without tuberculosis – PATH Blog | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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De quoi est-on mort au XXe siècle ?

De quoi est-on mort au XXe siècle ? | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Une infographie révèle les grandes causes de mortalité au cours du siècle dernier.


Via L'Info Autrement
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PLOS Pathogens: Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates

PLOS Pathogens: Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Human influenza infections exhibit a strong seasonal cycle in temperate regions. Recent laboratory and epidemiological evidence suggests that low specific humidity conditions facilitate the airborne survival and transmission of the influenza virus in temperate regions, resulting in annual winter epidemics. However, this relationship is unlikely to account for the epidemiology of influenza in tropical and subtropical regions where epidemics often occur during the rainy season or transmit year-round without a well-defined season. We assessed the role of specific humidity and other local climatic variables on influenza virus seasonality by modeling epidemiological and climatic information from 78 study sites sampled globally. We substantiated that there are two types of environmental conditions associated with seasonal influenza epidemics: “cold-dry” and “humid-rainy”. For sites where monthly average specific humidity or temperature decreases below thresholds of approximately 11–12 g/kg and 18–21°C during the year, influenza activity peaks during the cold-dry season (i.e., winter) when specific humidity and temperature are at minimal levels. For sites where specific humidity and temperature do not decrease below these thresholds, seasonal influenza activity is more likely to peak in months when average precipitation totals are maximal and greater than 150 mm per month. These findings provide a simple climate-based model rooted in empirical data that accounts for the diversity of seasonal influenza patterns observed across temperate, subtropical and tropical climates.


Via Ed Rybicki
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Ed Rybicki's curator insight, March 18, 2013 5:33 AM

This is really quite a big deal: I blogged recently on the first paper that explored this notion in detail; here we see that paper vindicated, and new data presented.

 

It is interesting that the virus should have evolved to be spread in this way: in drier cold air in temperate climates, and in warm wet air in more tropical climes.  It also very nicely explains seasonality in influenza transmission.

 

Now, let's do something ABOUT it!

Carl Shiu's comment, March 19, 2013 11:16 AM
Interesting data. In tropical climes, I wonder if this phenomenon is associated with the overcrowding of shelters during intense rainstorms. A temporary increase in population density during these events would likely facilitate increased rates of person-person transmission.
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The quest for the $1000 genome | ExtremeTech

The quest for the $1000 genome | ExtremeTech | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
After hundreds of thousands of years of prodding both intellectually and physically, after the rise of both human dualism and human dissection, it took little more than a century to build from the discovery of DNA to the total sequence of the human...
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Revealing Genetic Risks | The Scientist Magazine®

Revealing Genetic Risks | The Scientist Magazine® | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Genetics experts argue that patients should be told about dangerous variants in their DNA that show up incidentally during sequencing.
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CAFA, led by Miami computational biologist Iddo Friedberg, helps channel the flood of data from genome research to deduce the function of proteins

CAFA, led by Miami computational biologist Iddo Friedberg, helps channel the flood of data from genome research to deduce the function of proteins | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Miami University News public information office
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ASU scientists develop innovative twists to DNA nanotechnology

ASU scientists develop innovative twists to DNA nanotechnology | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
In a new discovery that represents a major step in solving a critical design challenge, Arizona State University Professor Hao Yan has led a research team to produce a wide variety of 2-D and 3-D stru...
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Research breakthrough edges first-ever CMV vaccine closer

Research breakthrough edges first-ever CMV vaccine closer | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
A research breakthrough may have provided scientists with a major step forward in developing the first-ever vaccine against cytomegalovirus (CMV). ...

Via Ed Rybicki
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Ed Rybicki's curator insight, March 21, 2013 10:01 AM

Interesting that it should have taken so long - but then, I suppose it IS an insidious customer, used to manipulating the immune system!

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Réseaux sociaux : quels droits et quels risques pour les salariés

Réseaux sociaux : quels droits et quels risques pour les salariés | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Entre liberté d'expression et protection des entreprises contre les abus de liberté, les premiers contours de la jurisprudence dédiée à l'utilisation des réseaux sociaux par les salariés au travail, voire en dehors du travail.
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German researchers publish full Neanderthal genome

German researchers publish full Neanderthal genome | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
(Phys.org) —The Max Planck Institute for Evolutionary Anthropology, in Leipzig, Germany, hascompleted the genome sequence of a Neandertal and makes the entire sequence available to the scientific community today.
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étude comparative de 9 plateformes open-source (Chamilo, Claroline, Dokeos, Formagri, Ganesha, Moodle, Ilias, Olat, Spiral) | Ma petite veille sur les TICE

étude comparative de 9 plateformes open-source (Chamilo, Claroline, Dokeos, Formagri, Ganesha, Moodle, Ilias, Olat, Spiral) | Ma petite veille sur les TICE | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Jean-Luc Peuvrier et Jean-Yves Loiget du cabinet Stratice, membre du FFFOD, ont présenté leur étude comparative de 9 plateformes open-source (Chamilo, Clarol (Comparaison de 9 plateformes open-source (Chamilo, Claroline, Dokeos, Formagri, Ganesha,...

Via Denis Hudrisier
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Whole brain cellular-level activity mapping in one second

Whole brain cellular-level activity mapping in one second | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Neuroscientists at Howard Hughes Medical Institute have mapped the activity of nearly all the neurons in a vertebrate brain at cellular resolution, with signficant implications for neuroscience research and projects like the proposed Brain Activity Map (BAM).

 

Fast volumetric imaging of the larval zebrafish brain with light-sheet microscopy (credit: Misha B Ahrens, Philipp J Keller/Nature Methods)

The researchers used high-speed light sheet microscopy to image the activity of 80% of the neurons in the brain (which is composed of ~100,000 neurons) of a fish larva at 0.8 Hz (an image every 1.3 seconds), with single-cell resolution.

 

This represents the first technology that achieves whole brain imaging of a vertebrate brain at cellular resolution with speeds that approximate neural activity patterns and behavior, as Nature Methodsmethagora blog noted.

The authors saw correlated activity patterns at the cellular level that spanned large areas of the brain — pointing to the existence of broadly distributed functional circuits.

 

The next steps will be to determine the causal role that these circuits play in behavior — something that will require improvements in the methods for 3D optogenetics, the blog said. Obtaining the detailed anatomical map of these circuits will also be key to understand the brain’s organization at its deepest level.


Via Dr. Stefan Gruenwald
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How proteins read meta DNA code

How proteins read meta DNA code | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Scientists have accurately calculated the sliding mechanism for deciphering the second genetic code written within the DNA base pair sequence


Via idtdna
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En transmettant des signaux, une protéine joue un rôle clé lors de l’entrée du VHC dans les cellules

En transmettant des signaux, une protéine joue un rôle clé lors de l’entrée du VHC dans les cellules | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
L’équipe du Professeur Thomas Baumert identifie les signaux qui permettent l’entrée du virus de l’hépatite C (VHC) dans les cellules du foie.
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New culturing tool reveals a full genome from single cells

New culturing tool reveals a full genome from single cells | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

A new technique for genetic analysis, “gel microdroplets,” helps scientists generate complete genomes from a single cell.


Via idtdna
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