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Institut Pasteur de Tunis-معهد باستور تونس
L’Institut Pasteur de Tunis (IPT) est un établissement public de santé et de recherche scientifique.







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Réseaux sociaux : quels droits et quels risques pour les salariés

Réseaux sociaux : quels droits et quels risques pour les salariés | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Entre liberté d'expression et protection des entreprises contre les abus de liberté, les premiers contours de la jurisprudence dédiée à l'utilisation des réseaux sociaux par les salariés au travail, voire en dehors du travail.
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German researchers publish full Neanderthal genome

German researchers publish full Neanderthal genome | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
(Phys.org) —The Max Planck Institute for Evolutionary Anthropology, in Leipzig, Germany, hascompleted the genome sequence of a Neandertal and makes the entire sequence available to the scientific community today.
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étude comparative de 9 plateformes open-source (Chamilo, Claroline, Dokeos, Formagri, Ganesha, Moodle, Ilias, Olat, Spiral) | Ma petite veille sur les TICE

étude comparative de 9 plateformes open-source (Chamilo, Claroline, Dokeos, Formagri, Ganesha, Moodle, Ilias, Olat, Spiral) | Ma petite veille sur les TICE | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Jean-Luc Peuvrier et Jean-Yves Loiget du cabinet Stratice, membre du FFFOD, ont présenté leur étude comparative de 9 plateformes open-source (Chamilo, Clarol (Comparaison de 9 plateformes open-source (Chamilo, Claroline, Dokeos, Formagri, Ganesha,...

Via Denis Hudrisier
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Whole brain cellular-level activity mapping in one second

Whole brain cellular-level activity mapping in one second | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Neuroscientists at Howard Hughes Medical Institute have mapped the activity of nearly all the neurons in a vertebrate brain at cellular resolution, with signficant implications for neuroscience research and projects like the proposed Brain Activity Map (BAM).

 

Fast volumetric imaging of the larval zebrafish brain with light-sheet microscopy (credit: Misha B Ahrens, Philipp J Keller/Nature Methods)

The researchers used high-speed light sheet microscopy to image the activity of 80% of the neurons in the brain (which is composed of ~100,000 neurons) of a fish larva at 0.8 Hz (an image every 1.3 seconds), with single-cell resolution.

 

This represents the first technology that achieves whole brain imaging of a vertebrate brain at cellular resolution with speeds that approximate neural activity patterns and behavior, as Nature Methodsmethagora blog noted.

The authors saw correlated activity patterns at the cellular level that spanned large areas of the brain — pointing to the existence of broadly distributed functional circuits.

 

The next steps will be to determine the causal role that these circuits play in behavior — something that will require improvements in the methods for 3D optogenetics, the blog said. Obtaining the detailed anatomical map of these circuits will also be key to understand the brain’s organization at its deepest level.


Via Dr. Stefan Gruenwald
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How proteins read meta DNA code

How proteins read meta DNA code | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Scientists have accurately calculated the sliding mechanism for deciphering the second genetic code written within the DNA base pair sequence


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En transmettant des signaux, une protéine joue un rôle clé lors de l’entrée du VHC dans les cellules

En transmettant des signaux, une protéine joue un rôle clé lors de l’entrée du VHC dans les cellules | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
L’équipe du Professeur Thomas Baumert identifie les signaux qui permettent l’entrée du virus de l’hépatite C (VHC) dans les cellules du foie.
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New culturing tool reveals a full genome from single cells

New culturing tool reveals a full genome from single cells | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

A new technique for genetic analysis, “gel microdroplets,” helps scientists generate complete genomes from a single cell.


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Conférence à Pasteur Tunis sur l'Utilisation de l'outil open source de gestion de bibliographie "zotero"

Conférence à Pasteur Tunis sur l'Utilisation de l'outil open source de gestion de bibliographie "zotero" | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Jeudi 21 mars 2013, à 11h00, dans le grand amphithéâtre de l'IPT, Mme Monia Triki, enseignante en recherche documentaire sur internet à l'Institut Supérieur des sciences infirmières de Tunis, donnera une conférence sur l'Utilisation de l'outil open source de gestion de bibliographie "zotero".

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La peste fait de nouvelles victimes à Madagascar

La peste fait de nouvelles victimes à Madagascar | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

 

Alors que la saison, chaude et humide, est propice à cette maladie, trois personnes en sont mortes ces deux dernières semaines dans un district situé une centaine de kilomètres au sud d’Antananarivo. Les autorités sanitaires craignent une épidémie d’ampleur.

 

C’est dans le district de Faratsiho, que la peste est la plus virulente. Cette semaine, deux personnes en sont mortes et une autre en avait été victime quelques jours plus tôt. La maladie a également été suspectée chez une vingtaine de malades qui ont été soignés.

 

Faratsiho est connu pour être un foyer pesteux explique le docteur Luc Randrianirina, le directeur de la lutte contre les maladies négligées. « C’est un foyer parce la peste est une maladie de rat...  compte tenu de l’hygiène, les rats sont porteurs de puces qui contiennent le bacille Yersinia Pestis.»

 


Via Bernadette Cassel
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Bernadette Cassel's curator insight, March 17, 2013 8:02 PM

 

SUR ENTOMOSCIENCE

From www.pasteur.fr - December 20, 2013 12:40 PM :


→ Généralités sur la Peste  


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Do Cats With FIV Foretell HIV’s Future? | PLOS Blogs Network

Do Cats With FIV Foretell HIV’s Future? | PLOS Blogs Network | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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Doctors: industry involvement in peer-reviewed publications | pharmaphorum

Doctors: industry involvement in peer-reviewed publications | pharmaphorum | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
This article is about doctors’ thoughts on industry involvement in peer-reviewed publications and the transparency of clinical trial data.
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Comment compte-on les animaux sauvages ?

Comment compte-on les animaux sauvages ? | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

 

Pour mesurer n’importe quelle population, il est nécessaire d'effectuer un échantillonnage sur un territoire précis. Les résultats sont ensuite extrapolés à la totalité de la population et permettent d’estimer sa densité, sa taille et son taux de croissance. Ces données varient dans le temps et l’espace, mais aussi selon l’espèce, le sexe et l’âge.

 

[...]

 

Pour les petits organismes aquatiques par exemple, les scientifiques utilisent une sorte de chaussette avec une hélice (un volucompteur) qui compte le volume d’eau filtrée. Au bout de celle-ci, une boîte recense les passages. Les données sont ensuite croisées avec le temps passé sur le terrain et la surface sondée pour établir l’échantillonnage.

 

Pour les fourmis, on peut utiliser des compteurs automatiques ou des aspirateurs qui capturent et dénombrent les insectes qui passent dans le tuyau.

 

[...]

 


Via Bernadette Cassel
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Viruses Might Be Actual Living Creatures, Capable of Stealing

Viruses Might Be Actual Living Creatures, Capable of Stealing | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Research published last week in Nature appears to add another point to the controversial argument that viruses might be living creatures. Scientists at Tufts University School of Medicine have found a virus that captures its host’s immune system and uses it to destroy the host.


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Vaginal gel loaded with bee venom may destroy HIV

Vaginal gel loaded with bee venom may destroy HIV | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Scientists develop nanoparticles to destroy HIV with bee venom, before infection even occurs.
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Sida : ces patients qui contrôlent leur infection

Sida : ces patients qui contrôlent leur infection | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
L'étude des - rares - malades en rémission sans traitement pourrait déboucher sur la mise au point d'un moyen d'éradiquer le sida.
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CIDRAP >> Human cell receptor for novel coronavirus discovered

CIDRAP >> Human cell receptor for novel coronavirus discovered | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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This Protein Could Change Biotech Forever - Forbes

This Protein Could Change Biotech Forever - Forbes | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
It started with a quest to make better yogurt.
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Picture the world without tuberculosis – PATH Blog

Picture the world without tuberculosis – PATH Blog | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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De quoi est-on mort au XXe siècle ?

De quoi est-on mort au XXe siècle ? | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Une infographie révèle les grandes causes de mortalité au cours du siècle dernier.


Via L'Info Autrement
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PLOS Pathogens: Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates

PLOS Pathogens: Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Human influenza infections exhibit a strong seasonal cycle in temperate regions. Recent laboratory and epidemiological evidence suggests that low specific humidity conditions facilitate the airborne survival and transmission of the influenza virus in temperate regions, resulting in annual winter epidemics. However, this relationship is unlikely to account for the epidemiology of influenza in tropical and subtropical regions where epidemics often occur during the rainy season or transmit year-round without a well-defined season. We assessed the role of specific humidity and other local climatic variables on influenza virus seasonality by modeling epidemiological and climatic information from 78 study sites sampled globally. We substantiated that there are two types of environmental conditions associated with seasonal influenza epidemics: “cold-dry” and “humid-rainy”. For sites where monthly average specific humidity or temperature decreases below thresholds of approximately 11–12 g/kg and 18–21°C during the year, influenza activity peaks during the cold-dry season (i.e., winter) when specific humidity and temperature are at minimal levels. For sites where specific humidity and temperature do not decrease below these thresholds, seasonal influenza activity is more likely to peak in months when average precipitation totals are maximal and greater than 150 mm per month. These findings provide a simple climate-based model rooted in empirical data that accounts for the diversity of seasonal influenza patterns observed across temperate, subtropical and tropical climates.


Via Ed Rybicki
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Ed Rybicki's curator insight, March 18, 2013 5:33 AM

This is really quite a big deal: I blogged recently on the first paper that explored this notion in detail; here we see that paper vindicated, and new data presented.

 

It is interesting that the virus should have evolved to be spread in this way: in drier cold air in temperate climates, and in warm wet air in more tropical climes.  It also very nicely explains seasonality in influenza transmission.

 

Now, let's do something ABOUT it!

Carl Shiu's comment, March 19, 2013 11:16 AM
Interesting data. In tropical climes, I wonder if this phenomenon is associated with the overcrowding of shelters during intense rainstorms. A temporary increase in population density during these events would likely facilitate increased rates of person-person transmission.
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Utilisation de l'outil open source de gestion de bibliographie "zotero"

Jeudi 21 mars 2013, à 11h00, dans le grand amphithéâtre de l'IPT, Mme Monia Triki, enseignante en recherche documentaire sur internet à l'Institut Supérieur des sciences infirmières de Tunis, donnera une conférence sur l'Utilisation de l'outil open source de gestion de bibliographie "zotero".

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Cool Tools for 21st Century Learners: 3 Engaging Note-Taking Apps

Cool Tools for 21st Century Learners: 3 Engaging Note-Taking Apps | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Via Doug Joubert, Aki Puustinen, Rui Guimarães Lima
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OMS/Europe | Le rapport sur la santé en Europe 2012

OMS/Europe | Le rapport sur la santé en Europe 2012 | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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PLOS Computational Biology: Chaste: An Open Source C++ Library for Computational Physiology and Biology

PLOS Computational Biology: Chaste: An Open Source C++ Library for Computational Physiology and Biology | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
PLOS Computational Biology is an open-access

Via Biswapriya Biswavas Misra
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Biswapriya Biswavas Misra's curator insight, March 15, 2013 2:50 PM
Abstract

Chaste — Cancer, Heart And Soft Tissue Environment — is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high-performance computational investigations of defibrillation on realistic human cardiac geometries. New models for the initiation and growth of tumours have been developed. In particular, cell-based simulations have provided novel insight into the role of stem cells in the colorectal crypt. Chaste is constantly evolving and is now being applied to a far wider range of problems. The code provides modules for handling common scientific computing components, such as meshes and solvers for ordinary and partial differential equations (ODEs/PDEs). Re-use of these components avoids the need for researchers to ‘re-invent the wheel’ with each new project, accelerating the rate of progress in new applications. Chaste is developed using industrially-derived techniques, in particular test-driven development, to ensure code quality, re-use and reliability. In this article we provide examples that illustrate the types of problems Chaste can be used to solve, which can be run on a desktop computer. We highlight some scientific studies that have used or are using Chaste, and the insights they have provided. The source code, both for specific releases and the development version, is available to download under an open source Berkeley Software Distribution (BSD) licence at http://www.cs.ox.ac.uk/chaste, together with details of a mailing list and links to documentation and tutorials.

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Most popular human cell in science gets sequenced

Most popular human cell in science gets sequenced | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

The HeLa cell genome is riddled with errors, raising questions about its continued use.


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