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Rescooped by Institut Pasteur de Tunis - معهد باستور تونس‎ from Immunology, vaccine & infectious diseases
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Immune cells identified that promote growth of beta cells in type 1 diabetes

Immune cells identified that promote growth of beta cells in type 1 diabetes | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Researchers have identified immune cells that promote growth of beta cells in type 1 diabetes.

Via Denis Hudrisier
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Institut Pasteur de Tunis-معهد باستور تونس
L’Institut Pasteur de Tunis (IPT) est un établissement public de santé et de recherche scientifique.







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In Gene Sequencing Treatment for Leukemia, Glimpses of the Future

In Gene Sequencing Treatment for Leukemia, Glimpses of the Future | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
A novel method known as whole genome sequencing focuses on genes that drive a cancer, not the tissues or organ where it originates.
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Bacteria: A day in the life

Bacteria: A day in the life | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
MIT study finds ocean bacteria follow predictable patterns of daily activity.
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Cooperating with the future

Overexploitation of renewable resources today has a high cost on the welfare of future generations. Unlike in other public goods games, however, future generations cannot reciprocate actions made today. What mechanisms can maintain cooperation with the future? To answer this question, we devise a new experimental paradigm, the /`Intergenerational Goods Game/'. A line-up of successive groups (generations) can each either extract a resource to exhaustion or leave something for the next group. Exhausting the resource maximizes the payoff for the present generation, but leaves all future generations empty-handed. Here we show that the resource is almost always destroyed if extraction decisions are made individually. This failure to cooperate with the future is driven primarily by a minority of individuals who extract far more than what is sustainable. In contrast, when extractions are democratically decided by vote, the resource is consistently sustained. Voting is effective for two reasons. First, it allows a majority of cooperators to restrain defectors. Second, it reassures conditional cooperators that their efforts are not futile. Voting, however, only promotes sustainability if it is binding for all involved. Our results have implications for policy interventions designed to sustain intergenerational public goods.

 

Cooperating with the future
Oliver P. Hauser, David G. Rand, Alexander Peysakhovich & Martin A. Nowak

Nature 511, 220–223 (10 July 2014) http://dx.doi.org/10.1038/nature13530


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Rapport 2013 de l'Institut Pasteur de Tunis

Rapport d'activité de l'année 2013 de l'Institut Pasteur de Tunis
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Ramadan : comment tenir sans manger pendant les jours les plus longs de l'année ?

Ramadan : comment tenir sans manger pendant les jours les plus longs de l'année ? | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Cette année, le Ramadan demandera des périodes de jeûne particulièrement longues. Francetv info répertorie 5 conseils pratiques pour ne pas trop souffrir en attendant les festivités du soir.  

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CYP1B1 Gene Mutations Causing Primary Congenital Glaucoma in Tunisia - Bouyacoub Y. - 2014 - Annals of Human Genetics - Wiley Online Library

CYP1B1 Gene Mutations Causing Primary Congenital Glaucoma in Tunisia - Bouyacoub Y. - 2014 - Annals of Human Genetics - Wiley Online Library | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Keywords:c.535delG;CYP1B1 gene;primary congenital glaucoma;p.G61E;proto-haplotype;Tunisian patientsSummary

Primary congenital glaucoma (PCG) is responsible for a significant proportion of childhood blindness in Tunisia. Early prevention based on genetic diagnosis is therefore required. This study sought to determine the frequency of CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1) mutations in 18 PCG patients, recruited from Central and Southern of Tunisia.

Genomic DNA was extracted and the coding regions of CYP1B1 were analysed by direct sequencing. A phylogenetic network of CYP1B1 haplotypes was drawn using the median-joining algorithm.

Sequence analysis revealed a “tetra-allelic mutation” (two novel mutations, p.F231I and p.P437A in the homozygous state) in one patient. The healthy members of his family carried those variations on the same allele. Two previously described mutations p.G61E and c.535delG were also identified in the homozygous state in seven and two probands, respectively. Seven single-nucleotide polymorphisms were identified and used to generate haplotypes.

Our results showed that the CYP1B1 mutations were present in 55% of Tunisian PCG patients’ alleles. Haplotype analysis allowed us to define the proto-haplotype and to confirm historical migratory flows. Establishment of PCG genetic aetiology in Tunisia will improve genetic diagnosis and counselling.

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Présentations LCMS-Agilent,24 juin 2014 à 9h00, amphithéâtre du bâtiment Recherche

Présentations LCMS-Agilent,24 juin 2014 à 9h00, amphithéâtre du bâtiment Recherche | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Le 24 juin 2014, le Dr. Georges Touspras de la société Agilent Technologie proposera les conférences suivantes à 9h00

9h00 – 9h45Agilent’s Tandem Mass spectrometry solutions9h45 – 10h30
Proteins discovery workflows  – Nano HPLC  Chip Cube  QTOF system10h30 – 10h45 Pause Café10h45 – 11h15 Proteins and Peptides Quantification  using  QQQ 11h15 – 11h45 Profiling and Biomarkers  discovery – Metabolomics  studies11h45 – 12h15 What does Ion Mobility Bring to Mass Spectrometry Questions et Discussions  ouvertes avec les intervenants 



Ces conférences sont en accès libre.

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Altmetric Launches New Tool to Help Academic Institutions Track and Report on Broader Impact of Research

Altmetric Launches New Tool to Help Academic Institutions Track and Report on Broader Impact of Research | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
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Reviewer guidelines | Elsevier

Reviewer guidelines | Elsevier | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Thank you for the effort and expertise that you contribute to reviewing, without which it would be impossible to maintain the high standards of peer-reviewed journals. Peer review is a critical element of scholarly publication, and one of the major cornerstones of the scientific process.

Via Nader Ale Ebrahim
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PhD Talk: Five platforms to increase the visibility of your research

PhD Talk: Five platforms to increase the visibility of your research | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

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Nader Ale Ebrahim's curator insight, June 18, 9:13 PM

As a young researcher, you like to share your work with the world. Even though I've focused on online tools you can use to increase the visibility of your research on this blog, there are other platforms that you can use to showcase your work.

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Social Media in Healthcare: The Patient’s Perspective

Social Media in Healthcare: The Patient’s Perspective | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
By Clarissa Schilstra The diagnosis of such a serious illness, whether it is acute like cancer or chronic like Type 1 diabetes, can leave a person feeling isolated and lost. You wonder why it has h...

Via Richard Meyer, Lionel Reichardt / le Pharmageek
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Whole Exome Sequencing Identifies New Causative Mutations in Tunisian Families with Non-Syndromic Deafness

Abstract

Identification of the causative mutations in patients affected by autosomal recessive non syndromic deafness (DFNB forms), is demanding due to genetic heterogeneity. After the exclusion of GJB2 mutations and other mutations previously reported in Tunisian deaf patients, we performed whole exome sequencing in patients affected with severe to profound deafness, from four unrelated consanguineous Tunisian families. Four biallelic non previously reported mutations were identified in three different genes: a nonsense mutation, c.208C>T (p.R70X), in LRTOMT, a missense mutation, c.5417T>C (p.L1806P), in MYO15A and two splice site mutations, c.7395+3G>A, and c.2260+2T>A, in MYO15A and TMC1 respectively. We thereby provide evidence that whole exome sequencing is a powerful, cost-effective screening tool to identify mutations causing recessive deafness in consanguineous families.

 

 

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12èmes journées scientifiques de la société tunisienne d'immunologie du 16 au 18 Octobre 2014

12èmes journées scientifiques de la société tunisienne d'immunologie du 16 au 18 Octobre 2014 | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
la Société Tunisienne d’Immunologie (STI) organise ses 12èmes journées scientifiques du 16 au 18 Octobre 2014 à l’hôtel Le Royal, Yasmine Hammamet avec comme thèmes :-          Vascularites -          Immunothérapie-          Sous-populations lymphocytairesT
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Chikungunya : les Antilles se mobilisent pour faire face à l'épidémie

Chikungunya : les Antilles se mobilisent pour faire face à l'épidémie | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
À la veille de la venue de la ministre de la Santé, Marisol Touraine, les Antilles multiplient les actions de sensiblisation des populations pour endiguer l’épidémie.
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Why Communicating With Patients Using Social Media is a Good Idea

Why Communicating With Patients Using Social Media is a Good Idea | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Most companies have a Facebook or twitter page; medical practices should also communicate with their patients using social media. The medical field has been less proactive when it comes to maintaining a social media presence. It’s an effective way to make sure your practice is branded in your specific field of expertise. Don’t overlook social media as a great way to communicate with your patients. People are looking for doctors who care and take time to get know their patients, this is where social media can shine.

Communicating with patients using social media creates a personal connection without having an appointment. Create a discussion on your facebook page where people can go to get answers to common questions regarding scheduling or areas of expertise within your practice. The way you respond to questions or complaints can carry a lot of weight; if people see that you take concerns seriously and respond in a timely fashion to requests it shows you care.

Social media is an easy way to get a message out to your patients. Post reminders about flu shots or sports physicals, whatever your specialty might be. Show your support for the local charities and fund drives you participate in. Ask your followers to fill out a patient survey, introduce new staff, link to beneficial health articles. Utilize social media as a new way to get important information to your patients. It’s a fast and free way to get important information and news to your patients.

Having a good social media presence will draw new patients in. It makes you easier to find and many potential new clients do their research for medical recommendations online. The reputation of a medical practice can be influenced by social media which is a good reason to learn how to manage yours.


Via Plus91, Stéphanie Chevrel
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Des images de protéines réalisées par une étudiante de l'IPT en UNE de la revue "Annals of Human Genetics"

Des images de protéines réalisées par une étudiante de l'IPT en UNE de la revue "Annals of Human Genetics" | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Des images de protéines réalisées par Yosra Bouyacoub, étudiante en fin de thèse au laboratoire de Génomique biomédicale et oncogénétique, premier auteur de l'article CYP1B1 Gene Mutations Causing Primary Congenital Glaucoma in Tunisia ont été publiées en UNE de l'édition du mois de juillet de la revue Annals of Human Genetics.

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Les 5 grands défis de la Big Data

Les 5 grands défis de la Big Data | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Prendre la data à bras le corps, c’est comprendre sa raison d’être et maitriser ses arcanes. Et parce que nous n’en sommes qu’à la genèse, il est bon de débuter directement avec les bonnes bases…

Via Vincent Datin
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رمضانكم مبروك

رمضانكم مبروك | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
 

 

 

 

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Transcriptomics of differential vector competence: West Nile virus infection in two populations of Culex pipiens quinquefasciatus linked to ovary development

Background:
Understanding mechanisms that contribute to viral dissemination in mosquito vectors will contribute to our ability to interfere with the transmission of viral pathogens that impact public health.

Via Mel Melendrez-Vallard
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Toward a Human Vaccines Project : Nature Immunology : Nature Publishing Group

Toward a Human Vaccines Project : Nature Immunology : Nature Publishing Group | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Technological advances in antigen discovery, genomics and immunological monitoring offer tremendous potential for revolutionizing vaccine development. On 5-6 February 2014, 35 leading vaccine scientists met to consider how best to harness these advances and spur innovation.
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Une nouvelle maladie par les tiques

Une nouvelle maladie par les tiques | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

 

Les tiques peuvent transmettre une mystérieuse maladie récemment découverte à Zurich. Si elle est repérée, elle se soigne bien. Le hic? Elle est très difficile à diagnostiquer.

 

[Image] « En plus de la borréliose et de l’encéphalite à tiques, l’arachnide peut transmettre la neoehrlichiose. »

 


Via Bernadette Cassel, Pascal Faucompré
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PhD Talk: How much time does a conference take?

PhD Talk: How much time does a conference take? | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it

Via Nader Ale Ebrahim
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Nader Ale Ebrahim's curator insight, June 18, 9:25 PM

It is interesting to know that:

1.3. Writing a paper - 20 hours

2.2. Networking - 3 days

 

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Moustiques, virus : recommandations sanitaires aux voyageurs 2014

Moustiques, virus : recommandations sanitaires aux voyageurs 2014 | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Avec les prochains départs des vacances d'été, le dernier bulletin épidémiologique hebdomadaire de l'Institut de veille sanitaire (IVS) tire la sonnette d'alarme sur les “maladies d'importation “.

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Mondial 2014 : Une nouvelle application pour combattre la dengue au Brésil

Mondial 2014 : Une nouvelle application pour combattre la dengue au Brésil | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Mondial 2014 : Une nouvelle application pour combattre la dengue au Brésil

Via Bernadette Cassel
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Des vidéos de science sur LeMonde.fr

Des vidéos de science sur LeMonde.fr | Institut Pasteur de Tunis-معهد باستور تونس | Scoop.it
Des vidéos de science sur LeMonde.fr
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