Overexploitation of renewable resources today has a high cost on the welfare of future generations. Unlike in other public goods games, however, future generations cannot reciprocate actions made today. What mechanisms can maintain cooperation with the future? To answer this question, we devise a new experimental paradigm, the /`Intergenerational Goods Game/'. A line-up of successive groups (generations) can each either extract a resource to exhaustion or leave something for the next group. Exhausting the resource maximizes the payoff for the present generation, but leaves all future generations empty-handed. Here we show that the resource is almost always destroyed if extraction decisions are made individually. This failure to cooperate with the future is driven primarily by a minority of individuals who extract far more than what is sustainable. In contrast, when extractions are democratically decided by vote, the resource is consistently sustained. Voting is effective for two reasons. First, it allows a majority of cooperators to restrain defectors. Second, it reassures conditional cooperators that their efforts are not futile. Voting, however, only promotes sustainability if it is binding for all involved. Our results have implications for policy interventions designed to sustain intergenerational public goods.
Cooperating with the future Oliver P. Hauser, David G. Rand, Alexander Peysakhovich & Martin A. Nowak
Primary congenital glaucoma (PCG) is responsible for a significant proportion of childhood blindness in Tunisia. Early prevention based on genetic diagnosis is therefore required. This study sought to determine the frequency of CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1) mutations in 18 PCG patients, recruited from Central and Southern of Tunisia.
Genomic DNA was extracted and the coding regions of CYP1B1 were analysed by direct sequencing. A phylogenetic network of CYP1B1 haplotypes was drawn using the median-joining algorithm.
Sequence analysis revealed a “tetra-allelic mutation” (two novel mutations, p.F231I and p.P437A in the homozygous state) in one patient. The healthy members of his family carried those variations on the same allele. Two previously described mutations p.G61E and c.535delG were also identified in the homozygous state in seven and two probands, respectively. Seven single-nucleotide polymorphisms were identified and used to generate haplotypes.
Our results showed that the CYP1B1 mutations were present in 55% of Tunisian PCG patients’ alleles. Haplotype analysis allowed us to define the proto-haplotype and to confirm historical migratory flows. Establishment of PCG genetic aetiology in Tunisia will improve genetic diagnosis and counselling.
Le 24 juin 2014, le Dr. Georges Touspras de la société Agilent Technologie proposera les conférences suivantes à 9h00
9h00 – 9h45Agilent’s Tandem Mass spectrometry solutions9h45 – 10h30 Proteins discovery workflows – Nano HPLC Chip Cube QTOF system10h30 – 10h45 Pause Café10h45 – 11h15 Proteins and Peptides Quantification using QQQ 11h15 – 11h45 Profiling and Biomarkers discovery – Metabolomics studies11h45 – 12h15 What does Ion Mobility Bring to Mass Spectrometry Questions et Discussions ouvertes avec les intervenants
Thank you for the effort and expertise that you contribute to reviewing, without which it would be impossible to maintain the high standards of peer-reviewed journals. Peer review is a critical element of scholarly publication, and one of the major cornerstones of the scientific process.
Identification of the causative mutations in patients affected by autosomal recessive non syndromic deafness (DFNB forms), is demanding due to genetic heterogeneity. After the exclusion of GJB2 mutations and other mutations previously reported in Tunisian deaf patients, we performed whole exome sequencing in patients affected with severe to profound deafness, from four unrelated consanguineous Tunisian families. Four biallelic non previously reported mutations were identified in three different genes: a nonsense mutation, c.208C>T (p.R70X), in LRTOMT, a missense mutation, c.5417T>C (p.L1806P), in MYO15A and two splice site mutations, c.7395+3G>A, and c.2260+2T>A, in MYO15A and TMC1 respectively. We thereby provide evidence that whole exome sequencing is a powerful, cost-effective screening tool to identify mutations causing recessive deafness in consanguineous families.
la Société Tunisienne d’Immunologie (STI) organise ses 12èmes journées scientifiques du 16 au 18 Octobre 2014 à l’hôtel Le Royal, Yasmine Hammamet avec comme thèmes :- Vascularites - Immunothérapie- Sous-populations lymphocytairesT
Most companies have a Facebook or twitter page; medical practices should also communicate with their patients using social media. The medical field has been less proactive when it comes to maintaining a social media presence. It’s an effective way to make sure your practice is branded in your specific field of expertise. Don’t overlook social media as a great way to communicate with your patients. People are looking for doctors who care and take time to get know their patients, this is where social media can shine.
Communicating with patients using social media creates a personal connection without having an appointment. Create a discussion on your facebook page where people can go to get answers to common questions regarding scheduling or areas of expertise within your practice. The way you respond to questions or complaints can carry a lot of weight; if people see that you take concerns seriously and respond in a timely fashion to requests it shows you care.
Social media is an easy way to get a message out to your patients. Post reminders about flu shots or sports physicals, whatever your specialty might be. Show your support for the local charities and fund drives you participate in. Ask your followers to fill out a patient survey, introduce new staff, link to beneficial health articles. Utilize social media as a new way to get important information to your patients. It’s a fast and free way to get important information and news to your patients.
Having a good social media presence will draw new patients in. It makes you easier to find and many potential new clients do their research for medical recommendations online. The reputation of a medical practice can be influenced by social media which is a good reason to learn how to manage yours.
Des images de protéines réalisées par Yosra Bouyacoub, étudiante en fin de thèse au laboratoire de Génomique biomédicale et oncogénétique, premier auteur de l'article CYP1B1 Gene Mutations Causing Primary Congenital Glaucoma in Tunisia ont été publiées en UNE de l'édition du mois de juillet de la revue Annals of Human Genetics.
Background: Understanding mechanisms that contribute to viral dissemination in mosquito vectors will contribute to our ability to interfere with the transmission of viral pathogens that impact public health.
Technological advances in antigen discovery, genomics and immunological monitoring offer tremendous potential for revolutionizing vaccine development. On 5-6 February 2014, 35 leading vaccine scientists met to consider how best to harness these advances and spur innovation.