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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
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Taking probiotics during pregnancy has no effect on asthma rate amoung infants - Meta-analysis

Taking probiotics during pregnancy has no effect on asthma rate amoung infants - Meta-analysis | Immunology for University Students | Scoop.it
AbstractObjective To evaluate the association of probiotic supplementation during pregnancy or infancy with childhood asthma and wheeze.Design Systematic review and meta-analysis of randomised controlled trials.Data sources Medline, Embase, and...
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BMJ. 2013 Dec 4;347:f6471. doi: 10.1136/bmj.f6471.Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis.Azad MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R.

 

 

 

Conclusions We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze. Randomised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders. Extended follow-up of existing trials, along with further clinical and basic research, are needed to accurately define the role of probiotics in the prevention of childhood asthma.

 

Press news:http://www.news-medical.net/news/20131209/Taking-probiotics-during-pregnancy-has-no-effect-on-asthma-rate-amoung-infants.aspx ;

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Natural killer cells help to tolerate fetus during pregnacy by regulating inflammatory TH17 cells at the maternal-fetal interface

Natural killer cells help to tolerate fetus during pregnacy by regulating inflammatory TH17 cells at the maternal-fetal interface | Immunology for University Students | Scoop.it
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Binqing Fua,Xianchang Lib,c,Rui Suna,Xianhong Tongd,Bin Lingd,Zhigang Tiana,1, andHaiming Weia,1

 

Natural killer (NK) cells accumulate at the maternal–fetal interface in large numbers, but their exact roles in successful pregnancy remain poorly defined. Here, we provide evidence that TH17 cells and local inflammation can occur at the maternal–fetal interface during natural allogenic pregnancies. We found that decidual NK cells promote immune tolerance and successful pregnancy by dampening inflammatory TH17 cells via IFN-γ secreted by the CD56brightCD27+ NK subset. This NK-cell–mediated regulatory response is lost in patients who experience recurrent spontaneous abortions, which results in a prominent TH17 response and extensive local inflammation. This local inflammatory response further affects the regulatory function of NK cells, leading to the eventual loss of maternal-fetal tolerance. Thus, our data identify NK cells as key regulatory cells at the maternal–fetal interface by suppressing TH17-mediated local inflammation.

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