Immunology for University Students
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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Stanford researchers unravel secrets of shape-shifting bacteria

Stanford researchers unravel secrets of shape-shifting bacteria | Immunology for University Students | Scoop.it
Working on observations of bacteria going undercover in ways that might trick the human immune system, Stanford bioengineers have created a time-lapse video that shows this process step by step.
Alfredo Corell's insight:

Using time-lapse microscopy, Stanford bioengineer K.C. Huang and colleagues reveal how bacteria lose the cell walls that define their shapes, become less visible to the immune system, then revert to original form and regain full infectious potential.

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WEB ADVENTURES: FOR STUDENTS — Explore Science and Medicine - One Game At A Time

WEB ADVENTURES: FOR STUDENTS — Explore Science and Medicine - One Game At A Time | Immunology for University Students | Scoop.it

MEDMYST is a collection of games to learn Science.

Some of the games are also available in Spanish:

http://webadventures.rice.edu/stu/Games/Espanol.html

 

Some games have mobile applications:

http://webadventures.rice.edu/stu/Games/Mobile-Applications/Germ-Blaster/

 

"MedMyst was a wonderful experience. Especially when you're trying to pursue a medical career.

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Immune-suppressing cells explain newborn infection vulnerability

Immune-suppressing cells explain newborn infection vulnerability | Immunology for University Students | Scoop.it
Cells that allow good bacteria to safely colonize the intestines of newborns may cause immune suppression, explaining why they are vulnerable to infection, researchers say.
Alfredo Corell's insight:

The researchers note that the process of CD71+ immune suppression is vital for the intestines to build up healthy bacterial colonization, and this is more important than the threat of neonatal infection.

However, they emphasize that further research is warranted in order to create new strategies for the protection of newborn infants against infection while still allowing the CD71+ cells to assist in developing healthy intestines.

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How Salmonella inactivates the immune system

How Salmonella inactivates the immune system | Immunology for University Students | Scoop.it

Science 16 November 2012:
Vol. 338 no. 6109 pp. 963-967
DOI: 10.1126/science.1227037

Report

Salmonella Inhibits Retrograde Trafficking of Mannose-6-Phosphate Receptors and Lysosome Function

Kieran McGourty1,Teresa L. Thurston1,Sophie A. Matthews1,Laurie Pinaud1,*,Luís Jaime Mota1,†,David W. Holden1,‡

 

 

Salmonella enterica is an intracellular bacterial pathogen that replicates within membrane-bound vacuoles through the action of effector proteins translocated into host cells. Salmonella vacuoles have characteristics of lysosomes but are reduced in hydrolytic enzymes transported by mannose-6-phosphate receptors (MPRs). We found that the effector SifA subverted Rab9-dependent retrograde trafficking of MPRs, thereby attenuating lysosome function. This required binding of SifA to its host cell target SKIP/PLEKHM2. Furthermore, SKIP regulated retrograde trafficking of MPRs in noninfected cells. Translocated SifA formed a stable complex with SKIP and Rab9 in infected cells. Sequestration of Rab9 by SifA-SKIP accounted for the effect of SifA on MPR transport and lysosome function. Growth of Salmonella increased in cells with reduced lysosomal activity and decreased in cells with higher lysosomal activity. These results suggest that Salmonella vacuoles undergo fusion with lysosomes whose potency has been reduced by SifA.

 

The new in Science Daily:

http://www.sciencedaily.com/releases/2012/11/121115141510.htm?goback=.gde_2370476_member_186426014

 

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Ashley Morrison's comment, August 13, 2013 12:38 PM
What are the precautions for avoiding such illnesses???