Immunology for University Students
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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Immunology Part 1- hypersensitivity states...

Immunology Part 1- hypersensitivity states... | Immunology for University Students | Scoop.it
Immunology as a branch of biomedical science, covers various aspects of immune system in organisms.It covers physiological functions of immune system in states of diseases and health. This video on...
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Not too worked videos (at least in eddition) introducing hypersensitivity states 3 and 4.

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Mechanisms of peripheral tolerance to allergens

Mechanisms of peripheral tolerance to allergens | Immunology for University Students | Scoop.it
Mechanisms of peripheral tolerance to allergensO. U. Soyer1,2,3,M. Akdis2,3,J. Ring3,4,H. Behrendt3,5,R. Crameri2,R. Lauener3,6,C. A. Akdis2,3,*

Article first published online: 18 DEC 2012

DOI: 10.1111/all.12085

Alfredo Corell's insight:

The immune system is regulated to protect the host from exaggerated stimulatory signals establishing a state of tolerance in healthy individuals. The disequilibrium in immune regulatory vs effector mechanisms results in allergic or autoimmune disorders in genetically predisposed subjects under certain environmental conditions. As demonstrated in allergen-specific immunotherapy and in the healthy immune response to high-dose allergen exposure models in humans, T regulatory cells are essential in the suppression of Th2-mediated inflammation, maintenance of immune tolerance, induction of the two suppressive cytokines interleukin-10 and transforming growth factor-β, inhibition of allergen-specific IgE, and enhancement of IgG4 and IgA. Also, suppression of dendritic cells, mast cells, and eosinophils contributes to the construction of peripheral tolerance to allergens. This review focuses on mechanisms of peripheral tolerance to allergens with special emphasis on recent developments in the area of immune regulation.

 

Link to the pdf file:

http://onlinelibrary.wiley.com/doi/10.1111/all.12085/pdf

 

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