Immunology for University Students
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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Intestinal epithelial cells: regulators of barrier function and immune homeostasis | Immunology for University Students | Scoop.it
Nature Reviews Immunology 14, 141 (2014).
doi:10.1038/nri3608
Authors: Lance W.
Alfredo Corell's insight:

The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host–microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine.


Free download with registration: http://www.nature.com/nri/journal/v14/n3/pdf/nri3608.pdf 

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Regulation of intestinal homeostasis and immunity with probiotic lactobacilli

Regulation of intestinal homeostasis and immunity with probiotic lactobacilli | Immunology for University Students | Scoop.it
Peter van Baarlen, Jerry M. Wells, Michiel Kleerebezem. The gut microbiota provide important stimuli to the human innate and adaptive immune system and co-mediate metabolic and immune homeostasis.
Alfredo Corell's insight:

The gut microbiota provide important stimuli to the human innate and adaptive immune system and co-mediate metabolic and immune homeostasis. Probiotic bacteria can be regarded as part of the natural human microbiota, and have been associated with improving homeostasis, albeit with different levels of success. Composition of microbiota, probiotic strain identity, and host genetic differences may account for differential modulation of immune responses by probiotics. Here, we review the mechanisms of immunomodulating capacities of specific probiotic strains, the responses they can induce in the host, and how microbiota and genetic differences between individuals may co-influence host responses and immune homeostasis.

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