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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Can antibiotics cause autoimmunity?

Can antibiotics cause autoimmunity? | Immunology for University Students | Scoop.it
A certain class of antibiotics prompts cells to produce low levels of novel self proteins that could trigger an autoimmune disease, research suggests.
Alfredo Corell's insight:

Link to the PNAS journal: http://www.pnas.org/content/early/2014/03/26/1402670111 


Significance

Many genetic disorders, including Duchenne muscular dystrophy and cystic fibrosis, are caused by a defective protein resulting from a premature termination codon (PTC) in the mutant gene. Aminoglycosides have been proposed as therapies for these disorders because they increase the frequency of translational read-through of PTCs, permitting expression of full-length protein. We consider the possibility that this approach may prompt an autoimmune response to HLA-presented epitopes encoded downstream of the PTC or other stop codons. We demonstrate that gentamicin induces immunologically relevant levels of an epitope derived from PTC read-through. Furthermore, we identify multiple HLA class I-binding peptides derived from read-through of conventional stop codons in gentamicin-treated cells. These results substantiate the possibility of immune autoreactivity from read-through therapies.

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Stress, Brain and Hormones and the Development of Organ Specific Autoimmunity

Stress, Brain and Hormones and the Development of Organ Specific Autoimmunity | Immunology for University Students | Scoop.it
The open access reference on the broad spectrum of brain-immune interactions and their impact on health and disease.
Alfredo Corell's insight:

As previously demonstrated, the development of autoimmunity in humans is the endpoint of a complex process involving the immune system, hormonal and environmental factors in a genetically predisposed individual, hence the term ‘mosaic of autoimmunity’.

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My collection of Educational Immunopathology and Immunology images and videos is growing. Suggestions wellcomed

My collection of Educational Immunopathology and Immunology images and videos is growing. Suggestions wellcomed | Immunology for University Students | Scoop.it
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Autoimmunity (self immunity) USMLE video animation

This immunology video explains autoimmunity and the effect of autoimmune symptoms in human body. For more information, log on to- http://shomusbiology.weebly...
Alfredo Corell's insight:

a simple and accesible video for Immunology university students

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The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology -

The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology - | Immunology for University Students | Scoop.it

The pathogenesis of systemic lupus erythematosus—an update

Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2,

1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States

http://dx.doi.org/10.1016/j.coi.2012.10.004,

 

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

 

The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK...

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Gilbert Faure au nom de l'ASSIM's comment, August 17, 2013 8:26 AM
november 2012, a synthetic review of uptodate hypothesis