Immunology for University Students
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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Can antibiotics cause autoimmunity?

Can antibiotics cause autoimmunity? | Immunology for University Students | Scoop.it
A certain class of antibiotics prompts cells to produce low levels of novel self proteins that could trigger an autoimmune disease, research suggests.
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Link to the PNAS journal: http://www.pnas.org/content/early/2014/03/26/1402670111 


Significance

Many genetic disorders, including Duchenne muscular dystrophy and cystic fibrosis, are caused by a defective protein resulting from a premature termination codon (PTC) in the mutant gene. Aminoglycosides have been proposed as therapies for these disorders because they increase the frequency of translational read-through of PTCs, permitting expression of full-length protein. We consider the possibility that this approach may prompt an autoimmune response to HLA-presented epitopes encoded downstream of the PTC or other stop codons. We demonstrate that gentamicin induces immunologically relevant levels of an epitope derived from PTC read-through. Furthermore, we identify multiple HLA class I-binding peptides derived from read-through of conventional stop codons in gentamicin-treated cells. These results substantiate the possibility of immune autoreactivity from read-through therapies.

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A novel innate ANTIBIOTIC discovered in animal cells. Potential therapeutic role if demonstrated in humans

A novel innate ANTIBIOTIC discovered in animal cells. Potential therapeutic role if demonstrated in humans | Immunology for University Students | Scoop.it

A novel role for lipid droplets in the organismal antibacterial response

Preetha Anand,1,† Silvia Cermelli,1,† Zhihuan Li,2 Adam Kassan,3 Marta Bosch,3 Robilyn Sigua,1 Lan Huang,1,4 Andre J Ouellette,5 Albert Pol,3,6 Michael A Welte,2 and Steven P Gross1,*

 

We previously discovered histones bound to cytosolic lipid droplets (LDs); here we show that this forms a cellular antibacterial defense system. Sequestered on droplets under normal conditions, in the presence of bacterial lipopolysaccharide (LPS) or lipoteichoic acid (LTA), histones are released from the droplets and kill bacteria efficiently in vitro. Droplet-bound histones also function in vivo: when injected into Drosophila embryos lacking droplet-bound histones, bacteria grow rapidly. In contrast, bacteria injected into embryos with droplet-bound histones die. Embryos with droplet-bound histones displayed more than a fourfold survival advantage when challenged with four different bacterial species. Our data suggests that this intracellular antibacterial defense system may function in adult flies, and also potentially in mice.

DOI: http://dx.doi.org/10.7554/eLife.00003.001

 

News in Science Daily:

http://www.sciencedaily.com/releases/2012/11/121113143656.htm?goback=.gde_2370476_member_185641076

 

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